Data acquisition begins with the physical phenomenon or physical property to be measured. Examples of this include temperature, gas pressure, and light intensity, and force, fluid flow, regardless of the type of physical property to be measured. Physical property converted into digital, and then by the computer for storage, processing, display or printing process, the corresponding system is called data acquisition system. With the rapid development of computer technology, data acquisition systems quickly gained popularity. A variety of products based on digital technology have been created. Digital System spread quickly; it’s mainly the following two advantages: the first is the digital processing flexible and convenient; the second is a digital system is very reliable. The main idea of Reconfigurable computing technology [1] is using the FPGA [2][3] allows the system has a dynamically configurable capacity, suitable for harsh environment applications, improve the speed of data processing. By the use of dynamic reconfigurable FPGA devices can be realized on the hardware logic function modification, application of reconfigurable computing technology can improve the speed of data processing. Data acquisition system is widely applied in many fields, and often used the abominable working environment place. The reconfigurable computing technology, can greatly improve the data acquisition system reliability and safety. The paper introduces a kind of multi-channel data acquisition system based on USB bus and FPGA, the factors affecting the performance of system are discussed, and describes how to use reconfigurable computing technology to improve the efficiency of data acquisition system while reduce energy consumption. The system in this paper uses AD's AD9220, ALTERA's EP1C6-8 and IDT's IDT70V24, Cypress’s CY7C68013.