Coma Science: The Territory and the Map

Stevens, Robert; Diringer, Michael N.

doi:10.1007/s12028-021-01292-3

Cited by 4 publications

(6 citation statements)

References 11 publications

(17 reference statements)

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“…The WG was divided into four subgroups whose remits were to (1) account for DoC heterogeneity to refine endotypes, (2) characterize DoC mechanisms by multiple spatialtemporal scales, (3) move Curing Coma science toward individualized prognostic tools, and (4) develop systemic frameworks to optimize therapeutic trials. Details related to recommendations from each of the subgroups were published separately [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

et al. 2022

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This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we summarize the background, research priorities, panel discussions, and deliverables discussed during the symposium across six major domains related to disorders of consciousness. The six domains include (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, and (6) Long-term Recovery. Following the 1st Curing Coma NIH virtual symposium held on September 9 to September 10, 2020, six workgroups, each consisting of field experts in respective domains, were formed and tasked with identifying gaps and developing key priorities and deliverables to advance the mission of the Curing Coma Campaign. The highly interactive and inspiring presentations and panel discussions during the 3-day virtual NIH symposium identified several action items for the Curing Coma Campaign mission, which we summarize in this article.

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Section: Introductionmentioning

confidence: 99%

Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

et al. 2022

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“…This team has two major objectives: to identify the unmet science of coma and DoC, and to identify novel or existing tools and research methods required to address the unmet science. [9] The Coma Science team has purposely opted for inclusivity of scientific directions. Research directions span a broad range of topics from artificial intelligence research methodology through genetic and molecular biological research to novel methods of brain mapping.…”

Section: Curing Coma Scientific Working Groupsmentioning

confidence: 99%

“…[7] Over the next 400 years the term was repeatedly refined in concert with new discoveries in functional neuroanatomy and physiology. [8,9] The intersection of coma with the concept of consciousness has thus intrigued those in medicine, art, and philosophy since antiquity. [7] It is in this context that many in the overall public, even without specific medical knowledge, have a familiarity with the concept of coma.…”

Section: Introductionmentioning

confidence: 99%

The Curing Coma Campaign and the Future of Coma Research

et al. 2022

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Recovery from coma or disordered consciousness is a central issue in patients with acute brain injuries such as stroke, trauma, cardiac arrest, and brain infections. Yet, major gaps remain in the scientific underpinnings of coma and this has led to inaccuracy in prognostication and limited interventions for coma recovery. Even so, recent studies have begun to elucidate mechanisms of consciousness early and prolonged after acute brain injury and some pilot interventions have begun to be tested. The importance and scope of this led in 2019 to the development of the Curing Coma Campaign, an initiative of the Neurocritical Care Society designed to provide a platform for scientific collaboration across the patient care continuum and to empower a community for purposes of research, education, implementation science, and advocacy. Seen as a “grand challenge,” the Curing Coma Campaign has developed an infrastructure of scientific working groups and operational modules, along with a 10-year roadmap.

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“…142,143 Acute DoC care is the focus of considerable study among clinicians, researchers, and ethicists, yet many fundamental questions surrounding optimal care remain unanswered. [144][145][146][147] Following onset of DoC, patients are typically transported to a medical center where they undergo initial evaluation and stabilization. Sometimes, a reversible cause of DoC may be identified and treated medically (e.g., hypoglycemia or opiate overdose).…”

Section: Acute Care Phasementioning

confidence: 99%

“…142 143 Acute DoC care is the focus of considerable study among clinicians, researchers, and ethicists, yet many fundamental questions surrounding optimal care remain unanswered. 144 145 146 147…”

Section: Acute Care Phasementioning

confidence: 99%

Neuroethics across the Disorders of Consciousness Care Continuum

Young

Peterson

2022

Semin Neurol

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This review provides an ethical analysis of disorders of consciousness (DoC) along the care continuum, from preinjury to injury, acute care to subacute care and early rehabilitation, and finally transitioning to chronic rehabilitation and societal reintegration. We provide an actionable, chronological assessment of ethical issues related to DoC care. This expands upon established ethics literature, which focuses almost exclusively on the clinical encounter for DoC. Our goal is to broaden the aperture of ethical analysis to address how social and environmental conditions predispose some persons to brain injury, and how such conditions might also pose barriers to meaningful societal reintegration after recovery.

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Coma Science: The Territory and the Map

Cited by 4 publications

References 11 publications

Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

The Curing Coma Campaign and the Future of Coma Research

Neuroethics across the Disorders of Consciousness Care Continuum

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