Combating hospital-acquired C. diff

Johnson, S. Roger

doi:10.1097/01.numa.0000530422.71453.11

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…[8] Many pathways affect aging, such as the insulin/insulin-like growth factor (IGF), the target of serine/threonine kinase mechanism of rapamycin complex (mTORC), and the protein kinase A (PKA) pathway. [9] In addition, the Nrf2 pathway, which regulates antioxidant capacity, and its downstream genes such as HO-1, thioredoxin reductase 1 (Txnrd1), and NAD(P)H-quinone oxidoreductase 1 (NQO1). [10] The Nrf2 signaling pathway mediates multiple cytoprotective pathways by activating the transcription of more than 200 genes that are essential in the metabolism of drugs and toxins, preventing oxidative stress and inflammation, and playing an integral role in maintaining protein stability, proteasomal degradation pathways, and autophagic removal of damaged proteins.…”

Section: Introductionmentioning

confidence: 99%

Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

Chen,

Liu,

Chen

et al. 2024

Molecular Nutrition Food Res

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Scope3,5‐Dihydroxy‐4‐methoxybenzyl alcohol (DHMBA) is found in oyster extracts in recent years and is reported to have antioxidant activity. Although it has been reported to be protective in various models of oxidative stress, the therapeutic effect of DHMBA on neurological damage caused by aging remains to be demonstrated.Methods and ResultsThe present study investigates the potential functions of DHMBA in brain of old C57BL/6J mice and aging cell model. Administration of DHMBA improves working memory, reduces anxiety behavior, decreases the expression levels of cell cycle proteins, cycin‐dependent kinase inhibitor 1(P21) and peptidase inhibitor 16(P16) and inhibits neuronal loss in old mice. The data obtained from the aging cell model are consistent with those from the old mice. The interaction between DHMBA and Kelch‐like ECH‐associated protein 1 (Keap1) is predicted by molecular docking assay, and then it is verified by co‐immunopricipitation (CoIP) that factor red lineage 2‐related factor 2 (Nrf2)‐Keap1 protein‐protein interaction is inhibited by DHMBA. Protein levels of Nrf2 and its target genes, such as glutathione peroxidase 4(GPX4) and heme oxygenase 1 (HO‐1), are detected in old mice and aging cell model.ConclusionThis study provides new evidence that explores the antioxidant mechanism of DHMBA and implies a potential role of DHMBA on antiaging in brain.

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Section: Introductionmentioning

confidence: 99%

Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

Chen,

Liu,

Chen

et al. 2024

Molecular Nutrition Food Res

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“…Once the bacteria colonize the host, certain factors are known to favor symptomatic disease development, the most common of which is the use of multiple types of antibiotics [ 4 ]. Antibiotics are related to CDI because antibiotic treatment disrupts the normal flora of the intestinal tract, which can lead to infection [ 8 ]. Exposure to certain antibiotics has been related to strain emergence, including the clindamycin-resistant “J strain,” which emerged largely due to clindamycin use, and the ribotype 027, which emerged largely due to fluoroquinolone use [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Clostridium difficile Infection Hospitalizations in the United States: Insights From the 2017 National Inpatient Sample

et al. 2021

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Background: There is a paucity of contemporary national estimates for Clostridium difficile infection (CDI) hospitalizations by age group, sex, and region in the US population. Also, there is lack of contemporary national statistics on CDI hospitalizations with comorbidities. Methods:We analyzed the 2017 National Inpatient Sample (NIS) to determine the population-based rates of CDI hospitalizations, characteristics of hospitalizations with CDI, and the rates of comorbidities associated with CDI hospitalizations.Results: There were 329,460 CDI-related hospitalizations in 2017 (almost 1% of all hospitalizations). The average age for patients admitted with CDI as a principal or secondary diagnosis was 64.7 years (almost 20 years older when compared with all other hospitalizations). Patients 85 years and older had the highest rate of CDI hospitalizations (716 per 100,000 hospitalizations), and patients less than 18 years of age had the lowest rate (12 per 100,000 hospitalizations). There was a progressive increase in the CDI hospitalization rates with each successive age group. The hospitalization rates were higher in females (114 per 100,000 hospitalizations) than males (88 per 100,000 hospitalizations). The CDI hospitalization rate was highest in the Northeast (109 per 100,000 hospitalizations) and lowest in the West (84 per 100,000 hospitalizations). Fluid and electrolyte disturbance (63.3%) and renal failure (33.4%) were the two most common comorbidities associated with CDI hospitalizations. When CDI is a secondary diagnosis, major loss of function, extreme likelihood of dying, septicemia, and septic shock were more common in comparison to CDI as a principal diagnosis.Conclusions: CDI hospitalization rates were highest in the elderly over 85 years old and declined with successive decreases in age. Women had higher CDI hospitalization rates than men, and fluid and electrolyte disturbances and renal failure were the most common comorbid conditions. The presence of CDI as a comorbid condition at the time of hospitalization for other principal diagnoses or development of CDI during a hospitalization for other principal diagnoses significantly increases the risk of in-hospital morbidity and mortality.

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Multidisciplinary Approach to Clostridium difficile Infection in Adult Surgical Patients

Turner

Behrens

Webster

et al. 2019

Journal of the American College of Surgeons

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Combating hospital-acquired C. diff

Abstract: A successful collaboration between clinical nurse leaders and clinical nurse specialists.

Cited by 5 publications

References 6 publications

Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

Potential Function of 3,5‐Dihydroxy‐4‐Methoxybenzyl Alcohol from Pacific Oyster (Crassostrea gigas) in Brain of Old Mice

Clostridium difficile Infection Hospitalizations in the United States: Insights From the 2017 National Inpatient Sample

Multidisciplinary Approach to Clostridium difficile Infection in Adult Surgical Patients

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