Combating obesity: a change in perspectives

Tham, KwangWei; Goh, GeorgeBoon Bee

doi:10.4103/singaporemedj.smj-2023-043

Cited by 6 publications

References 7 publications

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A novel nomogram for predicting optimal weight loss response following diet and exercise intervention in patients with obesity

Yu,

Wang,

et al. 2024

Sci Rep

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This study aimed to identify factors associated with optimal weight loss response by analyzing pre-weight loss data from a cohort of 2577 patients with obesity who visited weight management clinics between 2013 and 2022. Out of these, 1276 patients had follow-up data available. Following dietary and exercise interventions, 580 participants achieved optimal weight loss outcomes. Participants were subsequently divided into two groups based on their weight loss outcomes: those who achieved optimal weight loss response and those who did not. Statistical analysis, conducted using RStudio, identified thirteen predictor variables through LASSO and logistic regression, with age emerging as the most influential predictor. A nomogram was developed to predict optimal weight loss response, showing good predictive performance (AUC = 0.807) and clinical applicability, validated by internal validation methods. Decision curve analysis (DCA) further illustrated the nomogram's clinical utility. The developed nomogram prediction model for optimal weight loss response is user-friendly, highly accurate, and demonstrates excellent discriminative and calibration capabilities.

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A novel nomogram for predicting optimal weight loss response following diet and exercise intervention in patients with obesity

Yu,

Wang,

et al. 2024

Sci Rep

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The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications

El-Tanani,

Rabbani,

Aljabali

et al. 2024

Nutrition and Cancer

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HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration

Choijookhuu,

Yano,

Lkham-Erdene

et al. 2024

J Histochem Cytochem.

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Liver regeneration is a well-orchestrated compensatory process that is regulated by multiple factors. We recently reported the importance of the chromatin protein, a high-mobility group box 2 (HMGB2) in mouse liver regeneration. However, the molecular mechanism remains unclear. In this study, we aimed to study how HMGB2 regulates hepatocyte proliferation during liver regeneration. Seventy-percent partial hepatectomy (PHx) was performed in wild-type (WT) and HMGB2-knockout (KO) mice, and the liver tissues were used for microarray, immunohistochemistry, quantitative polymerase chain reaction (qPCR), and Western blotting analyses. In the WT mice, HMGB2-positive hepatocytes colocalized with cell proliferation markers. In the HMGB2-KO mice, hepatocyte proliferation was significantly decreased. Oil Red O staining revealed the transient accumulation of lipid droplets at 12–24 hr after PHx in the WT mouse livers. In contrast, decreased amount of lipid droplets were found in HMGB2-KO mouse livers, and it was preserved until 36 hr. The microarray, immunohistochemistry, and qPCR results demonstrated that the expression of lipid metabolism–related genes was significantly decreased in the HMGB2-KO mouse livers. The in vitro experiments demonstrated that a decrease in the amount of lipid droplets correlated with decreased cell proliferation activity in HMGB2-knockdown cells. HMGB2 promotes de novo lipogenesis to accelerate hepatocyte proliferation during liver regeneration:

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Combating obesity: a change in perspectives

Cited by 6 publications

References 7 publications

A novel nomogram for predicting optimal weight loss response following diet and exercise intervention in patients with obesity

A novel nomogram for predicting optimal weight loss response following diet and exercise intervention in patients with obesity

The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications

HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration

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