Combination antimicrobial therapy in the treatment of acute pelvic inflammatory disease

Landers, DV; Wølner‐Hanssen, Pål; Paavonen, E. Juulia; Thorpe, Edwin M.; Kiviat, Nancy B.; Ohm‐Smith, Marilyn; Green, JR; Schachter, Julius; Kk, Holmes; Eschenbach, D. A.; Rl, Sweet

doi:10.1016/0020-7292(92)90506-e

Cited by 6 publications

(8 citation statements)

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“…The prevalence of N. gonorrhoeae and C. trachomatis infections seems to vary greatly, depending on the population studied. The literature [17,18] shows a higher prevalence of N. gonorrhoeae than we found in our study.…”

Section: Commentcontrasting

confidence: 57%

A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease

Witte¹,

Peters²,

Šmit³

et al. 1993

European Journal of Obstetrics & Gynecology and Reproductiv

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SummaryA double-blind, randomised study was conducted to compare the efficacy and safety of a combination of pefloxacin and metronidazole versus doxycycline and metronidazole in patients with pelvic inflamma tory disease (PID). The clinical diagnosis had to be confirmed by laparoscopy before patients were includ ed. Of the 74 patients who fulfilled the clinical criteria for PID, laparoscopy confirmed the diagnosis in only 40 patients (54%). The microorganism most frequently found as causative pathogen was Chlamydia trachomatis. Both treatment groups showed a good response to the study-medication. At discharge 9 patients in the pefloxacin group (45%) were cured and 10 patients (50%) had improved. In the doxycycline group 7 patients (35%) were cured and 10 patients (50%) had improved. Obviously pefloxacin/metroni dazole and doxycycline/metronidazole are equally effective in the treatment of PID.

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Section: Commentcontrasting

confidence: 57%

A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease

Witte¹,

Peters²,

Šmit³

et al. 1993

European Journal of Obstetrics & Gynecology and Reproductiv

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“…The majority of published studies have looked at parenteral cefoxitin followed by oral doxycycline [27][28][29][30][31][32][33][34]. Cure rates for the different antibiotic regimens are presented in Table 3, although comparisons between studies should be interpreted with caution as the definition of cure, timing of outcome evaluation, and the use of per-protocol versus intention-to-treat analyses differ between studies, and several trials also have small patient numbers.…”

Section: Ceftriaxone (Or Cefoxitin) Plus Doxycycline and Metronidazolementioning

confidence: 99%

A review of antibiotic therapy for pelvic inflammatory disease

Duarte

Fuhrich

Ross

2015

International Journal of Antimicrobial Agents

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“…Others suggest that anaerobic coverage should be provided to all women with acute PID [1]. Clearly anaerobic bacteria have been demonstrated in the upper genital tract of women with acute PID with anaerobic bacteria recovered from the upper genital tract in 13% to 78% of women with PID [28][29][30][31][32][33][34][35]. In addition, anaerobes (e.g., Bacteroides fragilis) have caused tubal damage in vitro studies [1].…”

Section: Treatment Conceptsmentioning

confidence: 99%

Treatment of Acute Pelvic Inflammatory Disease

Sweet¹

1997

Pelvic Inflammatory Disease

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Pelvic inflammatory disease (PID), one of the most common infections in nonpregnant women of reproductive age, remains an important public health problem. It is associated with major long-term sequelae, including tubal factor infertility, ectopic pregnancy, and chronic pelvic pain. In addition, treatment of acute PID and its complications incurs substantial health care costs. Prevention of these long-term sequelae is dependent upon development of treatment strategies based on knowledge of the microbiologic etiology of acute PID. It is well accepted that acute PID is a polymicrobic infection. The sexually transmitted organisms, Neisseria gonorrhoeae and Chlamydia trachomatis, are present in many cases, and microorganisms comprising the endogenous vaginal and cervical flora are frequently associated with PID. This includes anaerobic and facultative bacteria, similar to those associated with bacterial vaginosis. Genital tract mycoplasmas, most importantly Mycoplasma genitalium, have recently also been implicated as a cause of acute PID. As a consequence, treatment regimens for acute PID should provide broad spectrum coverage that is effective against these microorganisms.

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Combination antimicrobial therapy in the treatment of acute pelvic inflammatory disease

Cited by 6 publications

References 0 publications

A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease

A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease

A review of antibiotic therapy for pelvic inflammatory disease

Treatment of Acute Pelvic Inflammatory Disease

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