Combination chemotherapy in advanced lung cancer with increased survival

Straus, Marc J.

doi:10.1002/1097-0142(197612)38:6<2232::aid-cncr2820380607>3.0.co;2-k

Cited by 29 publications

(5 citation statements)

References 7 publications

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“…Some bacterial proteins were demonstrated to induce host cell pathology by subcellular targeting, and some of these proteins have an NLS sequence. The cytolethal distending toxins of Gram‐negative bacteria such as Escherichia coli , Campylobacter sp , and Actinobacillus actinomycetemcomitans induce cell cycle arrest at the G2/M phase transition by nuclear targeting and ultimately induce cell death . The outer membrane protein A (AbOmpA) of Acinetobacter baumannii induces endonucleolytic attack of chromosomal DNA after nuclear translocation .…”

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confidence: 99%

Helicobacter pylori HP0425 Targets the Nucleus with DNase I‐Like Activity

et al. 2015

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Helicobacter pylori HP0425 Targets the Nucleus with DNase I‐Like Activity

et al. 2015

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“…This pattern was reflected in the results of each investigative procedure and underlines the difficulties in interpreting the results of therapeutic trials based on cytological or biopsy diagnoses of large cell carcinoma. 21 In any classification there has to be a group in which to place cases that cannot be classified into any of the other better-defined groups. In the context of this paper the undifferentiated large cell group is this residual group.…”

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Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma.

Payne¹,

Hadfield²,

Stovin³

et al. 1981

J Clin Pathol

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SUMMARY The accuracy of diagnosis in 656 patients with the four common histopathological types of primary lung cancer has been assessed by comparing the cell type diagnosis made on cytological and histological investigation with that determined by examination of the surgically resected or necropsy specimen. The accuracy of diagnosis achieved by cytological examination of sputum and bronchial aspirate, and by bronchial biopsy histology was over 85%. The least accurate diagnostic procedure was percutaneous needle biopsy (62%). Squamous and small cell tumours were accurately diagnosed by all four investigations but errors were made in the diagnosis of large cell and adenocarcinomas. Nearly half the number of patients (43%) with large cell carcinoma were later reclassified as having squamous carcinoma and of the patients with adenocarcinoma 32% had been predicted to be squamous and 18% large cell carcinoma. We consider such quality control of pretreatment diagnosis mandatory in management of individual patients and before enrolment in clinical trials.In 1979 a study was reported from Papworth Hospital, Cambridge which examined the accuracy of diagnosis of cell type in patients with primary lung cancer.' The presumptive cell type as predicted by cytology and biopsy techniques was compared with the true histological cell type as determined by histological examination of tumour tissue obtained at surgical resection or necropsy. The results indicated that the true cell type was most accurately predicted by sputum cytology (88 Y.), closely followed by bronchial aspiration (84%) and bronchial biopsy (80 %). The least accurate procedure was percutaneous needle biopsy (48 %). Diagnostic accuracy was highest in patients with squamous cell carcinoma while particular difficulty was experienced in diagnosis of patients with adenocarcinoma.Inevitably, with such a study limited to a four-year period in a single hospital, the number of patients in each histological group was relatively small. We have therefore undertaken a larger study of 673 patients with confirmed lung cancer seen at two centres, Papworth Hospital, Cambridge and Brompton Hospital, London and this includes the results of the original work from Papworth.

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“…64 The median survival of patients with metastatic bone disease is between 3 and 9 months. 65 Loblaw et al 66 found the median survival Epidural spinal cord compression is usually associated with inadequate control of the primary tumor, and the goal of treatment is palliative and directed at maintaining ambulation, decreasing tumor bulk, and relieving pain. 67 Those patients who develop spinal cord compromise secondary to metastatic disease often can be palliated effectively with short-course external beam radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…64 The median survival of patients with metastatic bone disease is between 3 and 9 months. 65 Loblaw et al 66 found the median survival from diagnosis of spinal cord compression for patients with lung cancer was 1.5 months and only 4.2% of patients survived 1 year. This study also demonstrated that cancer patients who had spinal cord compression in the last year of life spent twice as many days in the hospital than those who did not have spinal cord compression.…”

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confidence: 99%

Radiosurgery for the treatment of spinal lung metastases

Gerszten

Burton

Belani

et al. 2006

Cancer

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BACKGROUND. Spinal metastases are a common source of pain as well as neurologic deficit in patients with lung cancer. Metastases from lung cancer traditionally have been believed to be relatively responsive to radiation therapy. However, conventional external beam radiotherapy lacks the precision to allow delivery of large single‐fraction doses of radiation and simultaneously limit the dose to radiosensitive structures such as the spinal cord. The current study evaluated the efficacy of single‐fraction radiosurgery for the treatment of spinal lung cancer metastases. METHODS. In the current prospective cohort evaluation, 87 lung cancer metastases to the spine in 77 patients were treated with a single‐fraction radiosurgery technique with a follow‐up period of 6 to 40 months (median, 12 months). The indication for radiosurgery treatment was pain in 73 cases, as a primary treatment modality in 7 cases, for radiographic tumor progression in 4 cases, and for progressive neurologic deficit in 3 cases. RESULTS. Tumor volume ranged from 0.2 to 264 cm3 (mean, 25.7 cm3). The maximum tumor dose was maintained at 15 to 25 grays (Gy) (mean, 20 Gy; median, 20 Gy). No radiation‐induced toxicity occurred during the follow‐up period. Long‐term axial and radicular pain improvement occurred in 65 of 73 patients (89%) who were treated primarily for pain. Long‐term radiographic tumor control was observed in all patients who underwent radiosurgery as their primary treatment modality or for radiographic tumor progression. CONCLUSIONS. Spinal radiosurgery was found to be feasible, safe, and clinically effective for the treatment of spinal metastases from lung cancer. The results of the current study indicate the potential of radiosurgery in the treatment of patients with spinal lung metastases, especially those with solitary sites of spine involvement, to improve long‐term palliation. Cancer 2006. © 2006 American Cancer Society.

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Combination chemotherapy in advanced lung cancer with increased survival

Cited by 29 publications

References 7 publications

Helicobacter pylori HP0425 Targets the Nucleus with DNase I‐Like Activity

Helicobacter pylori HP0425 Targets the Nucleus with DNase I‐Like Activity

Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma.

Radiosurgery for the treatment of spinal lung metastases

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