Combination Chemotherapy With a Shocking Result

Genovese, Leonard; Chandrabhatla, Tejasri; Bagnola, Aaron; Tran, Henry A.; Naderi, Negar

doi:10.1016/s0735-1097(20)33869-9

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Recent Outcomes In the Application Of Combination Chemothera1

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“…However, in another case study, a 61-year-old man diagnosed with stage IV papillary and anaplastic thyroid cancer was subjected to the combination of dabrafenib and trametinib, which resulted in life-threatening arrhythmia. The patient's condition was severe enough was undergone plasmapheresis to remove the chemotherapeutic drugs [344] .…”

Section: Recent Outcomes In the Application Of Combination Chemotheramentioning

confidence: 99%

Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?

Mollaei

Hassan

Khorshidi

et al. 2021

Translational Oncology

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Highlight Chemotherapeutic drugs are classified into alkylating substrates, antimetabolite agents, anti-tumor antibiotics, inhibitors of topoisomerase I and II, mitotic inhibitors, and corticosteroids. Most of the chemotherapeutic drugs act in a dose-dependent manner; they either stimulate apoptosis or chemoresistance. Two major complications during chemotherapy are chemoresistance and tumor relapse. We have discussed underlying intracellular signaling cascades responsible for these events. Combination chemotherapies, targeted therapies, and immunotherapies have represented more promising responses than single chemotherapy applications. The role of omics, next-generation sequencing (NGS), whole-exome sequencing (WES), and machine learning technologies in precision medicine are currently under investigations for overcoming chemoresistance and tumor relapse.

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Section: Recent Outcomes In the Application Of Combination Chemotheramentioning

confidence: 99%