Combination drug delivery with actively-targeted PLGA nanoparticles to overcome multidrug resistance in breast cancer

Tonbul, Hayrettin; Sahin, Adem; Tavukçuoğlu, Ece; Esendağlı, Güneş; Çapan, Yılmaz

doi:10.1016/j.jddst.2019.101380

Cited by 24 publications

(11 citation statements)

References 47 publications

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“…This leads to enhance the importance of nanoparticles (NPs) to a greater extent in various industries such as chemical, biological, medicinal, and environmental. In addition, nanoparticles also using in the purification of water [ 3 ], packaging and processing of food [ 4 ], in the storage devices [ 5 , 6 ], fuel cells to catalytic converters and in biosensors [ 7 , 8 ], photocatalytic studies [ 9 ], in drug delivery [ 10 , 11 ] magnetic hyperthermia [ 12 , 13 ] magnetofection [ 14 ], antimicrobial agents, cytotoxic agents, bone regeneration, proliferation, and cell adhesion capabilities [ 15 ], tissue engineering [ 16 ], bio-labelling [ 17 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Saussurea lappa plant rhizome extract-based zinc oxide nanoparticles: synthesis, characterization and its antibacterial, antifungal activities and cytotoxic studies against Chinese Hamster Ovary (CHO) cell lines

Kolahalam

Prasad

Krishna

et al. 2021

Heliyon

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The plant extracts are known for their anti-inflammatory, antifungal, antiviral and antibacterial properties. The use of plant extracts in the preparation of bio-materials increases their biological application. In this concern, herein reporting an eco-friendly procedure which is also a simple and cost effective, for the synthesis of Zinc Oxide nanoparticles (ZnONPs) using Saussurea lappa plant root (rhizome) extract as a fuel. The prepared nanoparticles were confirmed using various characterization techniques. The Dynamic light scattering data showed 123.5 nm particle size with -99.9 mv zeta potential which indicates excellent stability of the particles. The peak at 541 cm À1 in the IR spectrum is assigned to the stretching frequency of the zinc-binding to oxygen. The X-ray diffraction peaks confirm the close association with JCPDS Data Card No: 36-1451. The FESEM data revealed a hexagonal wurtzite structure with a hexagonal shape of synthesized ZnO nanoparticles. The antibacterial studies indicate the gram-negative strains showed better inhibition activity than gram-positive strains. Among Fungal strains, Aspergillus niger and flavus, Fusarium oxysporum, and Rhizopus oryzae showed good inhibition activity at higher concentrations. The cytotoxic data indicates the 5 μg/mL of the ZnO particles showed cytotoxicity on the CHO cell line and with IC 50 value 3.164 AE 0.8956 μg/mL.

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Section: Introductionmentioning

confidence: 99%

Saussurea lappa plant rhizome extract-based zinc oxide nanoparticles: synthesis, characterization and its antibacterial, antifungal activities and cytotoxic studies against Chinese Hamster Ovary (CHO) cell lines

Kolahalam

Prasad

Krishna

et al. 2021

Heliyon

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“…(2020) Tariquidar PTX Folic acid modified erythrocytes In vitro and in vivo investigations in PTX-resistant MCF-7/taxol cells Superior cytotoxic profile through inducing apoptosis in 69.8% MCF-7/taxol cells in vitro (IC 50 = 6.30 μM) Zhong et al. (2020) Elacridar PTX Transferrin coated PLGA NPs EMT6/AR1.0-resistant BC cell line Sensitization of resistant cell line to PTX Tonbul et al. (2019) Zosquidar DOX pH-sensitive albumin conjugate MCF-7/ADR and MT-3/ADR DOX-resistant BC cell line Re-sensitization of cancer cell line to DOX Abu Ajaj et al.…”

Section: P-gp Inhibitors Investigated For Chemosensitization In Mdr Bcmentioning

confidence: 99%

“…(2019) Transferrin PTX- and elacridar-loaded PLGA NPs Transferrin-coated PLGA NPs demonstrated high cytotoxicity with a 16-fold decrease in IC 50 value. Tonbul et al. (2019) Folic acid-mediated active drug delivery Folic acid PTX and tariquidar co-loaded folic acid modified erythrocytes Better cytotoxicity was observed in vitro and in vivo investigations in taxol-resistant MCF-7/taxol cells in comparison to folic acid free erythrocytes.…”

Section: Ligands Used To Target Carriers To Mdr Bc Cellsmentioning

confidence: 99%

“…The presence of elacridar in the novel formulation sensitizes resistant EMT6/AR1.0 BC cell lines to PTX chemotherapy. The actively targeted novel PLGA NPs show significant cytotoxicity (cell viability, 33.77%) ( Tonbul et al., 2019 ). Zhu and co-workers have reported porous PLGA NPs for the co-delivery of DOC and vitamin E tocopheryl polyethylene glycol succinate (TPGS).…”

Section: Ligands Used To Target Carriers To Mdr Bc Cellsmentioning

confidence: 99%

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Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

Famta

Shah

Chatterjee

et al. 2021

Current Research in Pharmacology and Drug Discovery

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The high probability (13%) of women developing breast cancer in their lifetimes in America is exacerbated by the emergence of multidrug resistance after exposure to first-line chemotherapeutic agents. Permeation glycoprotein (P-gp)-mediated drug efflux is widely recognized as the major driver of this resistance. Initial in vitro and in vivo investigations of the co-delivery of chemotherapeutic agents and P-gp inhibitors have yielded satisfactory results; however, these results have not translated to clinical settings. The systemic delivery of multiple agents causes adverse effects and drug–drug interactions, and diminishes patient compliance. Nanocarrier-based site-specific delivery has recently gained substantial attention among researchers for its promise in circumventing the pitfalls associated with conventional therapy. In this review article, we focus on nanocarrier-based co-delivery approaches encompassing a wide range of P-gp inhibitors along with chemotherapeutic agents. We discuss the contributions of active targeting and stimuli responsive systems in imparting site-specific cytotoxicity and reducing both the dose and adverse effects.

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“…PLGA is metabolized in the body by Kreb’s cycle and gets degraded into lactic and glycolic acids, which are excreted through urine . The terminal groups of PLGA could be linked with ligand or drug molecules. , In recent times, PLGA has been explored as a multidrug delivery platform through its fabrication on various novel drug delivery carriers. , …”

Section: Introductionmentioning

confidence: 99%

Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo

Khan

Joshi

Sarkar

et al. 2020

ACS Appl. Bio Mater.

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Development of a biodegradable nanoplatform poly-(lactic-co-glycolic acid) (PLGA) for co-delivery of two drugs is hugely imperative and beneficial in anticancer therapeutics. In this study, co-delivery of a natural phytoconstituent, crocin (carotenoid), and a commonly prescribed drug, doxorubicin, was attempted using a nanoparticulate platform in the form of PLGA nanoparticles. Doxorubicin was chemically conjugated, while crocin was encapsulated physically in prepared PLGA nanoparticles (PDCR NPs). Prepared NPs were well-characterized for size, ζ, and surface morphology. PDCR NPs were of 174.2 ± 1.57 nm in size. The transmission electron microscopy (TEM) and atomic force microscopy (AFM) images revealed the spherical shape and smooth surface morphology of the nanoparticles, respectively. The entrapment efficiency and drug loading were found to be 58.95 ± 2.58 and 13.89 ± 1.09%, respectively. The drug release pattern of PDCR NPs showed a sustained and controlled release pattern throughout 48 h in PBS buffer pH 7.4 and acetate buffer pH 6.5. PDCR NPs were significantly less hemolytic than doxorubicin (p < 0.0001). Investigational formulation selectively produced cytotoxic effects on breast cancer cells via decreasing reactive oxygen species (ROS) and altering the mitochondrial potential that led to apoptosis with cell-cycle arrest at the G2/M phase. Prepared NPs were able to upregulate the caspase levels as well as efficient uptake by cells in a time-dependent manner. In vivo plasma drug profile studies in healthy rats revealed prolonged persistence of crocin and doxorubicin in systemic circulation. Additionally, the PDCR NPs portrayed reduced tumor volume as compared to control groups in the tumorinduced animal studies, which were favorable. Conclusively, the co-delivery of natural anticancer bioactive crocin along with doxorubicin in PDCR NPs provides a possible controlled-release nanoplatform for efficient drug delivery in vitro and in vivo.

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Combination drug delivery with actively-targeted PLGA nanoparticles to overcome multidrug resistance in breast cancer

Cited by 24 publications

References 47 publications

Saussurea lappa plant rhizome extract-based zinc oxide nanoparticles: synthesis, characterization and its antibacterial, antifungal activities and cytotoxic studies against Chinese Hamster Ovary (CHO) cell lines

Saussurea lappa plant rhizome extract-based zinc oxide nanoparticles: synthesis, characterization and its antibacterial, antifungal activities and cytotoxic studies against Chinese Hamster Ovary (CHO) cell lines

Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo

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