Combination of copeptin, placental growth factor and total annexin V microparticles for prediction of preeclampsia at 10–14 weeks of gestation

Proteomics Analysis Reveals Abnormal Electron Transport and Excessive Oxidative Stress Cause Mitochondrial Dysfunction in Placental Tissues of Early‐Onset Preeclampsia

“…Most researchers considered that early‐onset PE (EOS‐PE) occurred before 34 weeks, and late‐onset PE (LOS‐PE) occurred after the point time . EOS‐PE presented many typical clinical features distinguishing it from LOS‐PE, such as low quality of infants, intrauterine growth restriction (IUGR), low weight of the placenta, death of perinatal period, and other adverse pregnancy outcomes, resulted in transfer of oxygen and nutrients into fetus and then induced excessive oxidative stress and inflammation . The pathological changes had been regarded as adverse impacts on adult health of newborns, generating the latter pathologies, such as cardiovascular diseases, diabetes, and other metabolic syndromes .…”

Increase in regional oxygen saturation in the thigh indicates successful block of the femoral nerve after lumbar plexus block

“…Although the specificity of DrSO2 M was 100% for all time points, its highest sensitivity in indicating successful femoral block was only 69.2% with a cut-off value of 6.5, which was achieved 15 min after LPB. Combining DrSO2 M and pinprick test findings using a logistic regression may ameliorate this problem 7 : we found it increased sensitivity to 88.5% while maintaining specificity at 100% 15 min after LPB.…”

Cell-Derived Microparticles (MPs) and their Role in Unexplained Recurrent Pregnancy Loss

“…Platelet, leucocyte and endothelial MPs are found elevated in diabetes (Omoto et al, 1999;Omoto et al, 2002;Koga et al, 2005;Feng et al, 2010;Tramontanoet al, 2010) and pulmonary hypertension (Amabile et al, 2008(Amabile et al, , 2009Diehl et al, 2011). Elevated MP levels have been found in different thrombotic conditions(Zahra et al, 2011) like atherosclerosis, pulmonary hypertension, heart failure and also end-stage kidney disease (Amabile et al, 2005(Amabile et al, ,2012Faure et al, 2006); as well as in pregnancy complicated conditions like preeclampsia (PE) (Jadli et al, 2017), intra uterine fetal death, RPL (Patil et al, 2013) etc. Elevated red blood cell MPs have also been found associated with severe dengue (Punyadee et al, 2015).Thus, MPs act as a possible predictor of disease severity; and their origin helps us predict the pathological condition making them promising biomarker of the disease state.…”

“…Thus, MPs in combination with other markers (serum, etc.) could be used as a good predictor in the 10-14 th gestation weeks and to discriminate preeclampsia from other pregnancy complications (VanWijk et al, 2002a, b;González-Quintero et al, 2004;Marques et al, 2012;Jadli et al, 2017).…”