Combination of diffusion-weighted imaging and arterial spin labeling at 3.0 T for the clinical staging of nasopharyngeal carcinoma

Xiao, Bohan; Wang, Peiguo; Zhao, Yingru; Liu, Ying; Ye, Zhaoxiang

doi:10.1016/j.clinimag.2020.05.007

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…Xiao et al revealed higher BF on tumor as compared to the contralateral side of the tumor (64.3 ± 21.0 vs. 29.5 ± 9.7 mL/min/100 g), which was consistent with our study [17]. Moreover, other studies showed BF could help delineating the tumor extent by the fusion image of the BF map with T2WI [18] and evaluating clinical stages with moderate positive correlations to T stage and AJCC stage [19]. For head and neck tumors, studies suggested that ASL could assist the diagnosis and differentiation of pathological types of tumors [20,21], monitor the effect of head and neck tumor before and after non-surgical treatment, and evaluate the potential existence of residual tumors [22].…”

Section: Discussionsupporting

confidence: 92%

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

et al. 2020

Cancer Imaging

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Background: To investigate the diagnostic value of arterial spin labeling (ASL) and intravoxel incoherent motion (IVIM) imaging in distinguishing nasopharyngeal carcinoma (NPC) in T1 stage from healthy controls (HC). Methods: Forty-five newly diagnosed NPC patients in the T1 stage and thirty-one healthy volunteers who underwent MR examinations for both 3D pseudo-continuous ASL (pCASL) and IVIM were enrolled in this study. The Mann-Whitney test was used to compare the mean values of blood flow (BF) derived from pCASL and IVIM derived parameters, including apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f) between NPC tumor and benign nasopharyngeal mucosa of HC. Receiver Operating Characteristic (ROC) was performed to determine diagnostic cutoff and efficiency. The correlation coefficients among parameters were investigated using Spearman's test. Results: The NPC in the T1 stage showed higher mean BF, lower ADC, D, and f compared to benign nasopharyngeal mucosa (P < 0.001) with the area under curve of ROC of 0.742-0.996 (highest by BF). BF cutoff was set at > 36 mL/100 g/min; the corresponding sensitivity, specificity, and accuracy in differentiating NPC stage T1 from benign nasopharyngeal mucosa were 95.56% (43/45), 100% (31/31) and 97.37% (74/76), respectively. BF demonstrated moderate negative correlation with D* on HC (ρ [Spearman correlation coefficients] = − 0.426, P = 0.017). Conclusions: ASL and IVIM could reflect the difference in perfusion and diffusion between tumor and benign nasopharyngeal mucosa, indicating a potential for accessing early diagnosis of NPC. Notably, BF, with a specificity of 100%, demonstrated better performance compared to IVIM in distinguishing malignant lesions from healthy tissue.

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Section: Discussionsupporting

confidence: 92%

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

et al. 2020

Cancer Imaging

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“…Patients with lower ADC values were found to have higher iAUC60 in our cohort of patients. Nasopharyngeal tumours with higher cellularity and lower diffusability are leakier in vasculature than others [43] . It suggests that advanced nasopharyngeal tumour with high cellularity tends to have well-developed permeable vasculature, which is distinctly efficient in supporting proliferation and growth.…”

Section: Discussionmentioning

confidence: 96%

Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma

Mui¹,

Lee²,

Ng³

et al. 2022

Physics and Imaging in Radiation Oncology

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“…By using data on blood perfusion and capillary permeability, DCE-MRI and ASL can both assist in determining the stage of NPC. According to recent studies, high T stage and high AJCC stage tumors showed higher BF values than low T stage and low AJCC stage cancers [ 14 ]. Sriyook et al’s [ 15 ] research revealed a significant difference in Ktrans between the low T and high T stage.…”

Section: Discussionmentioning

confidence: 99%

The therapeutic utility of combining dynamic contrast-enhanced magnetic resonance imaging with arterial spin labeling in the staging of nasopharyngeal carcinoma

Gong

Wang

et al. 2023

BMC Med Imaging

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Background To research the pathological and clinical staging uses of arterial spin labeling (ASL) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and methods 64 newly diagnosed nasopharyngeal carcinoma (NPC) patients were enrolled from December 2020 to January 2022, and 3.0 T MRI (Discovery 750W, GE Healthcare, USA) were used for ASL and DCE-MRI scans. The DCE-MRI and ASL raw data were processed post-acquisition on the GE image processing workstation (GE Healthcare, ADW 4.7, USA). The volume transfer constant (Ktrans), blood flow (BF), and accompanying pseudo-color images were generated automatically. Draw the region of interest (ROIs), and the Ktrans and BF values for each ROI were recorded separately. Based on pathological information and the most recent AJCC staging criteria, patients were divided into low T stage groups = T1–2 and high T stage groups = T3–4, low N stage groups = N0–1 and high N stage groups = N2–3, and low AJCC stage group = stage I–II and high AJCC stage group = stage III–IV. The association between the Ktranst and BF parameters and the T, N, and AJCC stages was compared using an independent sample t-test. Using a receiver operating characteristic (ROC) curve, the sensitivity, specificity, and AUC of Ktranst, BFt, and their combined use in T and AJCC staging of NPC were investigated and assessed. Result The tumor-BF (BFt) (t = − 4.905, P < 0.001) and tumor-Ktrans (Ktranst) (t = − 3.113, P = 0.003) in the high T stage group were significantly higher than those in the low T stage group. The Ktranst in the high N stage group was significantly higher than that in the low N stage group (t = − 2.071, P = 0.042). The BFt (t = − 3.949, P < 0.001) and Ktranst (t = − 4.467, P < 0.001) in the high AJCC stage group were significantly higher than those in the low AJCC stage group. BFt was moderately positively correlated with the T stage (r = 0.529, P < 0.001) and AJCC stage (r = 0.445, P < 0.001). Ktranst was moderately positively correlated with T staging (r = 0.368), N staging (r = 0.254), and AJCC staging (r = 0.411). There was also a positive correlation between BF and Ktrans in gross tumor volume (GTV) (r = 0.540, P < 0.001), parotid (r = 0.323, P < 0.009) and lateral pterygoid muscle (r = 0.445, P < 0.001). The sensitivity of the combined application of Ktranst and BFt for AJCC staging increased from 76.5 and 78.4 to 86.3%, and the AUC value increased from 0.795 and 0.819 to 0.843, respectively. Conclusion Combining Ktrans and BF measures may make it possible to identify the clinical stages in NPC patients.

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Combination of diffusion-weighted imaging and arterial spin labeling at 3.0 T for the clinical staging of nasopharyngeal carcinoma

Cited by 3 publications

References 39 publications

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage

Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma

The therapeutic utility of combining dynamic contrast-enhanced magnetic resonance imaging with arterial spin labeling in the staging of nasopharyngeal carcinoma

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