Combination of response surface methodology and UPLC-QTOF-MSE for phenolic compounds analysis from Cinnamomum cassia bark as a novel antifungal agent

Bedjaoui, Kenza; Belbahi, Amine; Dahmoune, Farid; Djebari, Sabrina; Wrona, Magdalena; Nerı́n, Cristina; Soualah-alila, Hana; Nabet, Nassime; Kernou, Ourdia-Nouara; Madani, Khodir

doi:10.1007/s11694-023-01820-z

Cited by 5 publications

(2 citation statements)

References 94 publications

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“…Non-targeted screening in plant extracts using MS E data-independent acquisition has been implemented successfully in many studies, improving the accuracy in compound identification since it can simultaneously acquire low- and high-energy spectra of each detected feature, providing information on the precursor and fragment ions [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Methyl jasmonate (MeJA) Non-targeted screening in plant extracts using MS E data-independent a been implemented successfully in many studies, improving the accuracy identification since it can simultaneously acquire low-and high-energy s detected feature, providing information on the precursor and fragment ion Our study reports the use of elicitors on Phyllanthus acuminatus hairy The effects of SA and MeJA were evaluated for secondary metabolite elicit tative identification of more than 150 compounds present in Phyllanthus a Non-targeted screening in plant extracts using MS E data-independent acquisition has been implemented successfully in many studies, improving the accuracy in compound identification since it can simultaneously acquire low-and high-energy spectra of each detected feature, providing information on the precursor and fragment ions [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors in Phyllanthus acuminatus Hairy Roots by Non-Targeted Analysis Using High-Resolution Mass Spectrometry

Benavides,

Sánchez-Kopper,

Jiménez-Quesada

et al. 2023

Molecules

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Phyllanthus acuminatus has been studied for its vast medical and industrial potential. Phytochemical investigations reveal that the genus is a rich source of lignans, flavonoids, phenolics, terpenoids, and other metabolites. However, the phytochemical profile elucidation of this species still needs further research. The use of eliciting compounds such as salicylic acid and methyl jasmonate has managed to increase the production of secondary metabolites in plant cell cultures. Hairy roots of Phyllanthus acuminatus were produced in 250 mL flasks with a 16 h light/8 h darkness photoperiod under diffused light with a culture time of four weeks. The elicitors salicylic acid and methyl jasmonate were tested in 50 μM and 200 μM concentrations. Non-targeted analysis was done for the different treatments using HR-MS. Identified metabolites were grouped in phenylpropanoids, phenols, and mucic acids, and statistical analysis of relative concentrations was achieved. A significant change in phenols’ relative concentrations appeared in the elicitations with salicylic acid. Because of the elicitation treatment, specific compounds increased their concentrations, some of which have known pharmacological effects and are used in treating chronic diseases. The best elicitation treatment was salicylic acid 50 μM as it increased by more than 100% the general content of phenols and phenylpropanoid derivates and triplicates the concentration of mucic acid derivates in treated hairy root extracts. The application of non-targeted analysis showed interesting changes in phytochemical concentration due to elicitation in Phyllanthus acuminatus hairy roots.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors in Phyllanthus acuminatus Hairy Roots by Non-Targeted Analysis Using High-Resolution Mass Spectrometry

Benavides,

Sánchez-Kopper,

Jiménez-Quesada

et al. 2023

Molecules

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Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves

da Silva,

Fernandes,

dos Santos

et al. 2024

Chemistry & Biodiversity

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This study reports on the chemical composition and antileishmanial and anticandidal activities of volatile oils of Schinus molle dried leaves (SM), Cinnamomum cassia branch bark (CC) and their blends. Major constituents of SM were spathulenol (26.93%), β‐caryophyllene (19.90%), and caryophyllene oxide (12.69%), whereas (E)‐cinnamaldehyde (60.11%), cinnamyl acetate (20.90%) and cis‐2‐methoxycinnamic acid (10.37%) were predominant in CC. SM (IC50 = 21.45 µg/mL) and CC (IC50 = 23.27 µg/mL) displayed good activity against L. amazonensis promastigotes, besides having good or moderate activity against nine Candida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 µg/mL. While the three SM and CC blends were not more active than the EOs tested individually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 µg/mL, which is very similar to the IC50 of amphotericin B (positive control).

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The optimization of antioxidant and anti-inflammatory activities of carotenoids, total polyphenols, and indole alkaloids from coral Astroides calycularis and their interactions using simplex-centroid designs

Adouane,

Kadri,

Benzitoune

et al. 2024

Chem. Pap.

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Combination of response surface methodology and UPLC-QTOF-MSE for phenolic compounds analysis from Cinnamomum cassia bark as a novel antifungal agent

Cited by 5 publications

References 94 publications

Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors in Phyllanthus acuminatus Hairy Roots by Non-Targeted Analysis Using High-Resolution Mass Spectrometry

Evaluation of Salicylic Acid and Methyl Jasmonate as Elicitors in Phyllanthus acuminatus Hairy Roots by Non-Targeted Analysis Using High-Resolution Mass Spectrometry

Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves

The optimization of antioxidant and anti-inflammatory activities of carotenoids, total polyphenols, and indole alkaloids from coral Astroides calycularis and their interactions using simplex-centroid designs

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