Combination of Systemic and Topical Treatment for Feline Dermatophytosis: A Case Report

Indarjulianto, Soedarmanto; Yanuartono, Yanuartono; Nururrozi, Alfarisa; Raharjo, Slamet; Ajiguna, Jeffi Chandra

doi:10.29244/avi.8.1.18-23

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…The recovery status of both treatment groups is clearly illustrated in Figure 2. These results indicate that HOCl may also be an effective agent, similar to the results of different anti-mycotic trials on dermatophytosis (Ertaş et al, 2015;Odorcic et al, 2015;Wisal, 2018;Choi et al, 2019;Endo et al, 2020;Indarjulianto et al, 2020;Romanowski et al, 2020;Brescini et al, 2021).…”

Section: Resultssupporting

confidence: 78%

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The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

Babur

Karademir

2023

Turkish JAF Sci.Tech.

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Dermatophytosis is a mycotic disease of the skin that is resistant to treatment. The aim of this study was to investigate the treatment efficacy of a novel antimicrobial agent, Hypochlorous Acid (HOCL), on dermatophytosis of cats and dogs, in comparison with Ketaconazole. In this study, a total of 76 animals (26 cats and 50 dogs) without any disease other than skin fungal infection after clinical, hematological, biochemical, microscopic and Wood's lamp examinations were used. Subjects were randomly assigned to two equal treatment groups within their own species as HOCL: HP and Ketaconazole: KT. Naked eye inspection results were collected on the 8th, 11th and 15th days of all patients. The study was terminated on the 15th day by collecting the Wood's lamp and microscopic examination data together with the last inspection finding. Findings were analyzed statistically with chi-square and CART (Classification and Regression Tree) algorithm test. Inspection results of the treatment groups exhibited significant recovery over time (day 8, 11 and 15) for both species (p0.05). According to the microscopic examination results, a significant statistical difference was observed between the HP and KT groups (p0.05). As a result, it was concluded that HOCl has an effect on dermatophytosis of cat and dogs, although not as much as Ketaconazole, but further studies are needed to reveal the results more clearly.

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Section: Resultssupporting

confidence: 78%

“…Although dermatopytosis appears as a simple superficial disease on the skin, it is quite resistant to treatment. (Sánchez et al, 2014;Şimay and Karademir, 2015;Indarjulianto et al, 2020). Therefore, it can be treated with long and expensive treatment processes (Katiraee et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

Babur

Karademir

2023

Turkish JAF Sci.Tech.

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“…Complete recovery was achieved after 42 days of combination treatment using itraconazole and ketoconazole. Lesions reductions were shown after 20 days of itraconazole administration and of 35 days ketoconazole respectively [17]. However, it seems that the recovery process also depends on the severity of the disease in addition to the immune status of the host.…”

Section: Discussionmentioning

confidence: 99%

The use of propolis in ointment ingredient for the treatment of dermatophytosis infection

Kusumaningtyas,

Endrawati,

Siswandi

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Dermatophytosis in animals is very important since it is zoonotic. Propolis is a promising natural compound against pathogenic fungi since there is an increasing need to discover less expensive, more natural, and more accessible treatments. The purpose of this study was to evaluate propolis as an anti-dermatophyte and topical drug preparation against Trichophyton mentagrophytes. Propolis was tested for its antifungal properties at various concentrations using the diffusion method. The ointment was applied to the rabbit with dermatophytosis after being prepared by combining the ointment base with 10% propolis. The result demonstrated that propolis was able to inhibit the growth of Trichophyton mentagrophytes which was indicated by a clear zone around the disc. Propolis ointment helped lessen inflammation more than Miconazole 2% at severe lesions, according to in vivo trials on rabbits, while the two ointment’s healing times were nearly identical. According to the findings, propolis is a promising ointment ingredient for the treatment of dermatophytosis.

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“…Isolation and proper treatment of the infected animals and humans with adequate hygienic and disinfection measures should be explained by veterinarians to reduce the potential risk of zoonosis¹². As keratinized tissues are affected, dermatophytosis infection in cats appears as superficial dermatosis, multifocal circular patches of alopecia with scaling is the most commonly seen clinical sign noticed in cats, and they sometimes develop nodular dermatophyte lesions like mycetoma, psuedomycetoma, and kerion 13 . Direct examination of the hairs and scales confirms the presence of the infection.…”

Section: Discussionmentioning

confidence: 99%

Successful Management of Dermatophytosis in a Desi Short Hair Domestic Kitten

Naresh,

Arumugam,

Padmanaban

et al. 2023

Small Anim. Adv.

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Introduction: Dermatophytosis is an uncommon fungal infection of hair and skin in the claw. The infection is caused by the invasion of the hair shaft and stratum corneum by Keratophilic fungi. Fungal skin problems in pet animals commonly occur in hot and humid climatic regions. Cats suffer from superficial dermatophytosis despite their licking and self-cleansing behavior. Case report: A two-month-old female desi-short hair domestic kitten weighing 1.2 kg body weight was presented to Veterinary Clinical Complex, Kurumbapet, India, with a history of crusty patchy alopecic lesions on the rump and paw of the right forelimb for the past week in July 2022. The owner also reported generalized hair loss and scratching. Clinical examination revealed patchy circular dry lesions on the rump and the paw of the right forelimb. No abnormality was detected in the general appearance of the kitten. Behavioral habit was active, appetite and voiding habits were normal, popliteal lymph nodes were palpable, heart rate was 170 beats/minute, respiratory rate was 22 breaths/minute, rectal temperature was 101.8℉, and the conjunctival mucous membrane was pink. The pinna-pedal reflex was negative. Direct microscopy of the skin scraping sample revealed highly positive endothrix spores in the hair shaft. The smear prepared from the culture of the scrapings was stained with Lactophenol Cotton Blue, which confirmed the growth of ligamentous hyphae and mycelium of the dermatophyte, Microsporum spp. Hence, the case was diagnosed with superficial dermatophytosis caused by Microsporum spp. The kitten was successfully treated with itraconazole syrup (Felintra, Savavet, India) administered at the dosage of 5 mg/kg oral for 2 alternative weeks (every 24 hours for 7 days). Moreover, Cetirizine tablet as a non-sedating medicine and antihistamine which acts selectively on H1-receptor was given orally at the dosage of 2.5 mg/cat for the next 5 days, and liver supportive (Liv.52 syrup which contains herbal extracts) was administered orally at the dosage of 0.5 ml daily to overcome the hepatotoxic effect of anti-fungal drugs. Complete recovery was noticed by the third week of treatment which was the second week of the itraconazole syrup (Felintra, Savavet, India) treatment. Conclusion: Dermatophytosis in a kitten was diagnosed early and treated promptly with a proper treatment schedule with itraconazole without any untoward effects on the kitten.

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Combination of Systemic and Topical Treatment for Feline Dermatophytosis: A Case Report

Cited by 4 publications

References 13 publications

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

The use of propolis in ointment ingredient for the treatment of dermatophytosis infection

Successful Management of Dermatophytosis in a Desi Short Hair Domestic Kitten

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