Combination of total Astragalus extract and total Panax notoginseng saponins strengthened the protective effects on brain damage through improving energy metabolism and inhibiting apoptosis after cerebral ischemia-reperfusion in mice

Huang, Xiaoping; Hua, Tan; Chen, Beiyang; Deng, Chang-Qing

doi:10.1007/s11655-015-1965-0

Cited by 35 publications

(27 citation statements)

References 24 publications

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“…The energy‐rich phosphate compound synthesis was significantly reduced after cerebral ischemia. Astragalus extract, AS‐IV (20–40 mg/kg, 3–7 day) alone or in combination with tetramethylpyrazine, could reverse the decreased glucose metabolism, increase the ATP and ADP level, the Na+‐K+‐ATPase activity, and the EC value, and improve the energy synthesis and supply to attenuate cerebral ischemia damage .…”

Section: Pharmacological Effect Of Astragaloside IVmentioning

confidence: 99%

“…AS‐IV downregulated TNF‐α, IL‐1β, and other inflammatory cytokine expression by inhibiting the activation of NF‐κB signaling pathway via attenuating the phosphorylation of I κ B and decreasing the nuclear translocation of NF‐κB. The total astragalus extract also could decrease the apoptosis rate through the of JNK signaling transduction by downregulate the expression of p‐JNK1/2, Cyt‐C, caspase‐9, and caspase‐3 . Suppression of neutrophils’ adhesion‐related molecules. Neutrophils are acknowledged to be pivotal in inflammatory response, so it became a new approach to exert neuroprotection by suppression of neutrophil infiltration and activation after CIRI .…”

Section: Pharmacological Effect Of Astragaloside IVmentioning

confidence: 99%

See 1 more Smart Citation

Research review on the pharmacological effects of astragalosideIV

Hou²,

Rongfang³

et al. 2016

Fundamemntal Clinical Pharma

278

176

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Astragalus membranaceus Bunge has been used to treat numerous diseases for thousands of years. As the main active substance of Astragalus membranaceus Bunge, astragaloside IV (AS-IV) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic nephropathy. Based on studies published during the past several decades, the current state of AS-IV research and the pharmacological effects are detailed, elucidated, and summarized. This review systematically summarizes the pharmacological effects, metabolism mechanism, and the toxicity of AS-IV. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, AS-IV possesses potential for broad application in many diseases.

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Section: Pharmacological Effect Of Astragaloside IVmentioning

confidence: 99%

Section: Pharmacological Effect Of Astragaloside IVmentioning

confidence: 99%

Research review on the pharmacological effects of astragalosideIV

Hou²,

Rongfang³

et al. 2016

Fundamemntal Clinical Pharma

278

176

View full text Add to dashboard Cite

show abstract

“…Astragaloside IV (AS‐IV), an important derivative of A. membranaceus , could alleviate airway inflammation when it was applicated early in asthma. AS‐IV is able to inhibit the inflammatory response and provide the protective effect on the respiratory system (Brouns & De Deyn, ; Huang, Tan, Chen, & Deng, ; Jin, Yang, & Li, ). Besides, some studies showed AS‐IV attenuates the eosinophilic infiltration in ovalbumin‐induced asthma (Du et al, ; Gu, Jiang, Wang, Du, & Cai, ; Huang, Tang, Wang, & Song, ).…”

Section: Discussionmentioning

confidence: 99%

“…# p < 0.05 and ## p < 0.01 compared with control group; *p < 0.05 and **p < 0.01 compared with OVA group [Colour figure can be viewed at wileyonlinelibrary.com] could alleviate airway inflammation when it was applicated early in asthma. AS-IV is able to inhibit the inflammatory response and provide the protective effect on the respiratory system (Brouns & De Deyn, 2009;Huang, Tan, Chen, & Deng, 2017;Jin, Yang, & Li, 2010).…”

Section: Discussionmentioning

confidence: 99%

The effect of astragaloside IV on JAK2‐STAT6 signalling pathway in mouse model of ovalbumin‐induced asthma

Yang

Wang

2019

Animal Physiology Nutrition

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Asthma is a chronic inflammatory lung disease of the airway; the incidence and prevalence of asthma remain high worldwide. Astragaloside IV (AS‐IV) is the main active constituent of Astragalus membranaceus. Accumulating evidence suggests that AS‐IV possesses anti‐inflammatory and anti‐asthmatic ability, but the potential molecular mechanism is required to further clarify. In this study, the anti‐asthmatic effects of AS‐IV on mice with ovalbumin (OVA)‐induced allergic inflammation were analysed. We analysed airway hyperresponsiveness (AHR), numbers of inflammatory cells, inflammation situation in lung tissue and cytokines level in bronchoalveolar lavage fluid (BALF) between OVA‐induced mice with and without AS‐IV treatment. Moreover, we explored the possible signalling pathway behind the anti‐asthmatic effects. Our results revealed that AS‐IV treatment ameliorates airway inflammation and AHR in an OVA‐induced asthma model. Besides, AS‐IV treatment inhibits the interleukin (IL)‐4, ‐5 and ‐13 production, and further study indicated that AS‐IV treatment downregulates the expression level of p‐JAK2/p‐STAT6 proteins. Taken together, the present study suggested that the inhibitory effects of AS‐IV on asthma therapy are at least partially involved in inhibiting the JAK2/STAT6 signalling pathway.

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“…Emerging data show that PNS and its constituents have anti-inflammatory [10, 11], anti-oxidant [12, 13], and anti-apoptotic properties [13, 14] in both global and focal ischemic cerebrovascular disease. However, it is not clear whether PNS have a protective impact on the restoration of microvascular dyshomeostasis, which is essential to tissue survival after I/R.…”

Section: Introductionmentioning

confidence: 99%

<b><i>Panax notoginseng</i></b> Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice

Jia

Dong

et al. 2019

J Vasc Res

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Panax notoginseng saponins (PNS) are known as clinical anti-stroke herbal medicines. The aim of this study is to describe the impact of PNS on ischemia-reperfusion-induced cerebral microvasculature barrier dysfunction which has not been investigated yet. Mice were subjected to transient middle cerebral artery occlusion and PNS were administrated to mice 3 days before and 2 days after surgery. Leukocyte adhesion, albumin leakage, tight junctions and other parameters in the cortex were measured. The PNS 45 mg/kg intervention alleviated leukocyte adhesion, inhibited endothelial barrier alterations evidenced by reduced albumin leakage and tight junction degradations, and ultimately ameliorated infarct volumes and neurological deficits subsequent to ischemia-reperfusion. Taken together, P. notoginseng saponins are able to attenuate leukocyte-mediated microvascular disturbance at the onset of ischemic stroke.

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Combination of total Astragalus extract and total Panax notoginseng saponins strengthened the protective effects on brain damage through improving energy metabolism and inhibiting apoptosis after cerebral ischemia-reperfusion in mice

Cited by 35 publications

References 24 publications

Research review on the pharmacological effects of astragalosideIV

Research review on the pharmacological effects of astragalosideIV

The effect of astragaloside IV on JAK2‐STAT6 signalling pathway in mouse model of ovalbumin‐induced asthma

<b><i>Panax notoginseng</i></b> Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice

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