Combination strategies for enhancing transdermal absorption of sumatriptan through skin

Femenía-Font, A.; Balaguer-Fernández, C.; Merino, Virginia; López-Castellano, Alicia

doi:10.1016/j.ijpharm.2006.05.049

Cited by 28 publications

(19 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that substances within the formulation produced an additive effect apart from that of the chemical enhancer. Similar findings have been reported in experiments carried out with a drug solution (Femenía-Font et al, 2006b). Furthermore, we observed that higher amounts of sumatriptan were retained in the skin after the transdermal diffusion experiments (Table 3), which constituted a depot in the skin when the system was retired.…”

Section: Resultssupporting

confidence: 89%

“…Even though the permeability of porcine skin differs from that of human skin, this animal model is appropriate for the screening and selection of techniques for enhancing the transdermal delivery of drugs (Dick & Scott, 1992;Simon & Maibach, 2000;Godin & Touitou, 2007) and the analysis of the permeation of many drugs including sumatriptan succinate (Femenía-Font et al, 2006b). Figure 6 shows the permeation profiles of sumatriptan succinate obtained in the transdermal diffusion experiments performed.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate

et al. 2010

Self Cite

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate

et al. 2010

Self Cite

View full text Add to dashboard Cite

“…The outermost layer of human epidermis, the stratum corneum, is a lipid-protein hydrophobic structure which plays the main role against the penetration of water and hydrophilic molecules. Keratinocytes of the epidermis, on the contrary, are constructed of polar lipids that form a barrier against lipophilic substances [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Safety of Topical Methimazole for the Treatment of Melasma

Kasraee

Ardekani²,

Parhizgar³

et al. 2008

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Methimazole is an oral antithyroid compound that exhibits a skin-depigmenting effect when used topically. However, the effect of topical methimazole on thyroid function has not been reported. This study was aimed at assessing the safety of topical methimazole used to treat pigmented lesions, without affecting thyroid hormones due to systemic delivery. The pharmacokinetics of methimazole, either applied in the form of a 5% topical formulation to facial skin or taken orally in the form of a 5-mg tablet by 6 volunteers, were determined. In addition, the effect of long-term topical applications of 5% methimazole on the function of the thyroid gland in 20 patients with epidermal melasma was determined following 6 weeks of once-daily application. Cutaneous adverse effects of topical methimazole were determined. From 15 min up to 24 h after application, methimazole was undetectable in the serum of the individuals receiving single topical methimazole dosing. Methimazole, however, was detected in serum after 15 min of oral administration and remained detectable in serum up to 24 h after administration. Long-term topical methimazole applications in melasma patients did not induce any significant changes in serum TSH, free thyroxine and free triiodothyronine levels. Topical methimazole was well tolerated by the patients and did not induce any significant cutaneous side effects. Present data together with the previously shown non-cytotoxic and non-mutagenic characteristics of methimazole indicate that this agent could be considered as a safe skin-depigmenting compound for topical treatment of skin hyperpigmentary disorders in humans.

show abstract

“…[38][39][40][41][42] These methods are useful for screening tests or mechanistic analysis of chemical enhancer function in laboratory experiments, but they have little practical value. Urea and Tween 80, used in the present study, are suitable for practical use because their hydrophilic properties allow them to dissolve easily into aqueous drug donor solutions and because of their charge-free behavior, which avoids the risk of competition.…”

Section: )mentioning

confidence: 99%

Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers

Yamamoto¹,

Takasuga²,

Kominami³

et al. 2013

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

The aim of the present study was to evaluate the feasibility of transdermal delivery of glycyrrhizin, an agent used in the treatment of chronic hepatitis C, by cathodal iontophoresis using Ag/AgCl electrodes in vitro. The effects of donor pH (pH 4-7), concentration of drug (0.025-0.2% (w/v)), concentration of external chloride ions (Cl ) (0-133 mM), current strength (0-0.5 mA/cm 2 ), and permeation enhancers (urea and Tween 80) on the skin permeability of glycyrrhizin were examined in in vitro skin permeation studies using porcine ear skin as the membrane. The cumulative amount of permeated glycyrrhizin and the steady-state skin permeation flux of glycyrrhizin across porcine skin increased in a pH-dependent manner. The skin permeability of glycyrrhizin was independent of the concentration of drug and competed only with a high external Cl concentration. The skin permeation flux of glycyrrhizin increased with the current (R 2 0.8955). The combination of iontophoresis and enhancers provided an additive or synergistic effect, and a skin permeation flux of about 60 µg/h/cm 2 was achieved. The plasma concentration of glycyrrhizin in humans, extrapolated from the in vitro steady-state permeation flux across porcine skin, was within the therapeutic level. These results suggest that cathodal iontophoresis can be used as a transdermal drug delivery system for glycyrrhizin using reasonable patch sizes and acceptable levels of current intensity.

show abstract

Combination strategies for enhancing transdermal absorption of sumatriptan through skin

Cited by 28 publications

References 16 publications

Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate

Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate

Safety of Topical Methimazole for the Treatment of Melasma

Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers

Contact Info

Product

Resources

About