Combination therapy for bulky auricular keloids: a clinical experience

Yang, Yanqing; Jiang, Changyan; Xu, Qijun

doi:10.1080/14764172.2018.1439963

Cited by 8 publications

(14 citation statements)

References 16 publications

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“…Auricular keloids are usually caused by ear piercing, infection, surgery and trauma, and so on, with high risks of local malformation, complications and recurrence. In addition, it often proliferates and enlarges for many years, or even invades the surrounding normal skin, seriously affecting the appearance [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…As a result, the treatment is greatly restricted. At present, there are many means of treatments for auricular keloids, but treatment effects were poor and recurrence rates were high [3,4]. It was reported that the recurrence rate of surgery alone was as high as 45-100%, and that of glucocorticoid injection alone in lesions was 9-50% [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…At present, there are many means of treatments for auricular keloids, but treatment effects were poor and recurrence rates were high [3,4]. It was reported that the recurrence rate of surgery alone was as high as 45-100%, and that of glucocorticoid injection alone in lesions was 9-50% [3,5]. Therefore, most scholars currently advocated comprehensive treatment [6][7][8], which will conducted surgery first, and then combined with some relevant auxiliary treatments, such as hormones, pressure therapy, radiotherapy, and so on.…”

Section: Introductionmentioning

confidence: 99%

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Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids

Sun

Zhou

et al. 2021

BMC Surg

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Background Although multiple methods have been proposed to treat auricular keloids, low curative effects and high recurrence rates are currently major clinical problems. Thereinto, surgery combined with radiotherapy and triamcinolone acetonide injection is considered to be the proper choice for comprehensive treatment of auricular keloids. This study aimed at evaluating the therapeutic effect of individualized surgery combined with radiotherapy for the treatment of auricular keloids. Methods From February 2014 to February 2017, 67 patients with 113 auricular keloids in total were enrolled in this study. According to specific conditions of lesions, the local tissue and patients’ individual wishes, different surgical methods were selected to analyze the scar excision and repairment of the defect. Within 24 h after the keloid was excised, 5 MeV electron beam irradiation by the linear accelerator was used by radiotherapy with a total dose of 20 Gy at interval of 1 day for 10 consecutive times. Triamcinolone acetonide was injected immediately after surgery, and per month afterward in the following three months. Results 113 keloids in total were received treatment. The follow-up period was 24 months. Fourteen keloids (12.39%) showed subjective recurrence with a success rate of 87.61%. Wilcoxon matched-pairs rank-sum test was used to compare the differences of the 24-month postoperative VSS scores and the preoperative VSS scores. The VSS scores were as follows: 82 keloids (72.57%) scored less than 5 points (good result), 21 keloids (18.58%) scored 6 to 10 points (fair result), and only 10 keloids (8.85%) scored more than 10 points (bad result). The effective rate was 91.15%. Conclusions Individualized surgery combined with early postoperative radiotherapy and triamcinolone acetonide injection is an ideal treatment method to ensure good auricular appearance, low incidences of complications and recurrence based on effective treatment of auricular keloids.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids

Sun

Zhou

et al. 2021

BMC Surg

View full text Add to dashboard Cite

show abstract

“…In addition, it often proliferates and enlarges for many years, or even invades the surrounding normal skin, seriously affecting the appearance. 3 Effective treatment relies to a large extent on the understanding of pathogenesis, but the pathogenesis is complex and has not yet been fully revealed. As a result, the treatment is greatly restricted.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 It was reported that the recurrence rate of surgery alone was as high as 45% to 100%, and that of glucocorticoid injection alone in lesions was 9% to 50%. 3,5 Therefore, most scholars currently advocated comprehensive treatment, [6][7][8] that is, surgery rst, and then combined with some relevant auxiliary treatment, such as hormones, pressure therapy, radiotherapy, and so on. Among them, surgery combined with radiotherapy and triamcinolone acetonide injection may be the preferred scheme of comprehensive treatment for auricular keloids.…”

Section: Introductionmentioning

confidence: 99%

Individualized Surgery Combined with Radiotherapy and Triamcinolone Acetonide Injection for the treatment of Auricular Keloids

Sun

Zhou

et al. 2021

Preprint

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Background: Although multiple methods have been proposed to treat auricular keloids, low curative effects and high recurrence rates are currently major clinical problems. Thereinto, surgery combined with radiotherapy and triamcinolone acetonide injection is considered to be the proper choice for comprehensive treatment of auricular keloids.Objective: This study aimed to evaluate the therapeutic effect of individualized surgery combined with radiotherapy for the treatment of auricular keloids. Methods: From February 2014 to February 2017, a total of 67 patients with 113 auricular keloids were enrolled in this study. According to the specific conditions of the lesions, the local tissue and the patient's wishes, different surgical methods were selected for scar excision and repair of the defect. Within 24 hours after the keloid was excised, 5 Mev electron beam irradiation by the linear accelerator was used for radiotherapy with a total dose of 20 Gy at interval of 1 day for 10 consecutive times. Triamcinolone acetonide was injected immediately after 1, 2, and 3 months after surgery.Results: A total of 113 keloids were received treatment. The follow-up period was 24 months. Fourteen keloids (12.39%) showed subjective recurrence with a success rate of 87.61%. The VSS scores were as follows: 82 keloids (72.57%) scored less than 5 points (good result), 21 keloids (18.58%) scored 6 to 10 points (fair result), and only 10 keloids (8.85%) scored more than 10 points (bad result). The effective rate was 91.15%.Conclusions: Individualized surgery combined with early postoperative radiotherapy and triamcinolone acetonide injection is an ideal treatment method to ensure good auricular appearance, low incidences of complications and recurrence based on effective treatment of auricular keloids.

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Optimizing surgical outcome of auricular keloid with a novel multimodal approach

Hung

Lin

Tzeng

et al. 2022

Sci Rep

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Various treatments are available for auricular keloids, but none has an absolute advantage. A practical and safe therapy to optimize the surgical outcome for auricular keloids is needed. We adopted a multimodal treatment of surgical enucleation, core fillet flap reconstruction, intraoperative corticosteroid injection, and immediate postoperative radiotherapy. There were no routine intralesional corticosteroid injections during follow-up. Keloid recurrences, complications, and risk factors for recurrences were analyzed. The outcome was compared with other published literatures. 45 auricular keloids were included in this study. 85.7% were female with an average age of 27.1 ± 7.5 years, and averaged size was 1.8 × 1.2 ± 0.9 × 0.6 cm. 71.1% were located at ear helix with 28.9% at the ear lobe. Nine keloids were classified as Chang-Park classification type I, 30 for type II, two for type III, and four for IV. The average radiation dosage was 1578.6 cGy. The recurrence rate was 6.7% at an average 24.1-month follow-up. There were no complications of surgery, radiotherapy, and intralesional corticosteroid injection. Our recurrence rate was lower than those in mono-adjuvant therapies of intraoperative corticosteroid injection or radiotherapy. This one-session multimodal approach optimizes treating auricular keloids with a low recurrence rate and minimal post-radiation and long-term corticosteroid injection-related complications.

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Combination therapy for bulky auricular keloids: a clinical experience

Cited by 8 publications

References 16 publications

Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids

Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids

Individualized Surgery Combined with Radiotherapy and Triamcinolone Acetonide Injection for the treatment of Auricular Keloids

Optimizing surgical outcome of auricular keloid with a novel multimodal approach

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