Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma

Seki, Toshihito; Tamai, Toru; Nakagawa, Taiichi; Imamura, Masato; Nishimura, Akira; Yamashiki, Noriyo; Ikeda, Kozo; Inoue, Katsumi

doi:10.1002/1097-0142(20000915)89:6<1245::aid-cncr8>3.0.co;2-f

Cited by 136 publications

(58 citation statements)

References 13 publications

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“…These regional therapies are hopeful in further improving the prognosis of HCC patients who have no opportunity to receive surgical treatment or postoperative recurrence. The combination of these treatment modalities is hopeful to further improve the prognosis of HCC patients [59,60] .…”

Section: Treatment Strategies Relatedmentioning

confidence: 99%

The prognostic significance of clinical and pathological features in hepatocellular carcinoma

Qin¹,

Tang²

2002

WJG

161

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The prognosis of patients with HCC still remains dismal. The life expectancy of HCC patients is hard to predict because of the high possibility of postoperative recurrence. Many factors, s u c h a s p a t i e n t ' s g e n e r a l c o n d i t i o n s , macroscopic tumor morphology, as well as tumor hitopathology features, have been proven of prognostic significance. Female HCC patient often has a better prognosis than male patient, which might be due to the receptor of sex hormones. Younger patients often have tumors with higher invasiveness and metastatic potentials, and their survival and prognosis are w o r s e t h a n t h e o l d e r o n e s . C o -e x i s t i n g hepatitis status and hepatic functional reserve h a v e b e e n c o n f i r m e d a s r i s k f a c t o r s f o r recurrence. Serum alpha-fetoprotein (AFP) is useful not only for diagnosis, but also as a prognostic indicator for HCC patients. AFP mRNA has been proposed as a predictive marker of HCC cells disseminated into the circulation and for metastatic recurrence. Many pathologic features, such as tumor size, number, capsule state, cell differentiation, venous invasion, intrahepatic spreading, and a d v a n c e d p T N M s t a g e , a r e t h e b e s testablished risk factors for recurrence and important aspects affecting the prognosis of patients with HCC. Marked inflammatory cell infiltration in the tumor could predict a better prognosis. Clinical stage is still the most important factor influencing on the prognosis. E x t r a t u m o r s p r e a d i n g a n d l y m p h n o d a l metastasis are independent predictors for poor outcome. Some new predictive systems h a v e r e c e n t l y b e e n p r o p o s e d . D i f f e r e n t strategies of treatment might have significant different effects on the patients' prognosis. To date, surgical resection is still the only p o t e n t i a l l y c u r a t i v e t r e a t m e n t f o r H C C , including localized postoperative recurrences. Extent of resection, blood transfusion, occlusion of porta hepatis, and blood loss affect the survival and prognosis of HCC patients. Regional therapies provide alternative ways to improve the prognosis of HCC patients who have no opportunity to receive surgical treatment or postoperative recurrence. The combination of these treatment modalities is hopeful to further improve the prognosis. The efficacies of neoadjuvant (preoperative) or adjuvant (postoperative) chemotherapy or chemoembolization in preventing recurrence and on the HCC prognosis still remain great controversy, and deserves further evaluation. Biotherapy, including IFN-alpha therapy, will play more important role in preventing recurrence and metastasis of HCC after operation.Qin LX,Tang ZY.The prognostic significance of clinical and pathological features in hepatocellular carcinoma.

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Section: Treatment Strategies Relatedmentioning

confidence: 99%

The prognostic significance of clinical and pathological features in hepatocellular carcinoma

Qin¹,

Tang²

2002

WJG

161

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“…Our study examined 5 aspects -average survival time, TNM stage, differentiation grade, R&M, and survival rate -that inform HCC prognosis (Farinati et al, 2000;Seki et al, 2000). The results demonstrate that 1) the MIF-794CATT 5-8 promoter low-repetitive-sequence genotype (5/5+5/6+6/6) confers a better prognosis than that of the high-repetitive-sequence genotype (7/x+8/x), and 2) the MIF-794CATT promoter microsatellite repetitive sequence contributes to the postoperative prognosis of HCC.…”

Section: Discussionmentioning

confidence: 99%

Influence of the human MIF promoter polymorphism on hepatocellular carcinoma prognosis

Yuan¹,

Tang²,

Chen³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. Macrophage migration inhibition factor (MIF) is related to many cancers; hence, the polymorphism of MIF genes may be associated with the surgical prognosis of HCC. The purpose of this study was to investigate the relationship between polymorphisms of MIF gene promoter 794CATT (MIF-794CATT) microsatellite repeats and HCC surgical prognosis and evaluate the contribution of polymorphism to the prognosis of hepatectomy. Sequencing was used to identify the MIF-794CATT of 241 patients who had been submitted to HCC surgery. These patients were classified into 2 groups: one with MIF-794CATT highrepetitive-sequence genotypes (7/x+8/x) and one with low-repetitivesequence genotypes (5/5+5/6+6/6). Five indictors were analyzed: average survival times were compared using the t-test, and tumor-node-metastasis (2013) staging, recurrence and metastasis, differentiation grade, and survival rate were compared using the chi-square test. The (7/x+8/x) CATT group had 139 patients and the (5/5+5/6+6/6) CATT group had 102. Significant differences were found in the 5 factors (P = 0.000, 0.008, 0.002, 0.000, and 0.003, respectively). Patients with MIF-794CATT 5-8 low-repetitivesequence genotypes had better prognosis than those with high-repetitivesequence genotypes. The polymorphism detection of MIF-794CATT microsatellite repeats is valuable for HCC surgical prognosis.

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“…Seki et al [20] treated 18 cases of small HCC of less than 3 cm using PMCT, and achieved complete necrosis in 17 of them. After a follow-up of 12-31 mo, all the patients were still alive.…”

Section: Discussionmentioning

confidence: 99%

Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma

Weizhu¹,

Jiang²,

Huang³

et al. 2009

WJG

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AIM:To assess the efficacy of combined transcatheter arterial chemoembolization (TACE) and percutaneous microwave coagulation therapy (PMCT) for small hepatocellular carcinoma (HCC). METHODS:Thirty-five patients with a total of 41 HCC nodules (≤ 3 cm in diameter) were treated with TACE followed by computed tomograghy (CT)-guided percutaneous microwave coagulation therapy (PMCT) within 1-3 wk. RESULTS:By biopsies and enhanced CT scans, complete necrosis of the tumor and 3-5 mm of the surrounding non-cancerous area were observed in 34 foci. In seven foci, incomplete necrosis of the surrounding parenchyma was observed. Serum alphafetoprotein (AFP) levels returned to normal 10 d after treatment in 25 patients who originally had high serum AFP levels. The follow-up period was 6-31 mo, and all patients remained alive. One patient had a recurrence in the subsegments of the liver, and another patient had a recurrence near the original lesion. CONCLUSION:Combined therapy with TACE and PMCT is a safe and effective treatment without severe complications for small HCC.

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Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma

Cited by 136 publications

References 13 publications

The prognostic significance of clinical and pathological features in hepatocellular carcinoma

The prognostic significance of clinical and pathological features in hepatocellular carcinoma

Influence of the human MIF promoter polymorphism on hepatocellular carcinoma prognosis

Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma

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