Combination treatment by 10 600 nm ablative fractional carbon dioxide laser and narrowband ultraviolet B in refractory nonsegmental vitiligo: a prospective, randomized half-body comparative study

Shin, Jeonghyun; Js, Lee; Sk, Hann; Oh, Sang Ho

doi:10.1111/j.1365-2133.2011.10723.x

Cited by 81 publications

(107 citation statements)

References 11 publications

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“…In 2004, fractional laser therapy was developed to reduce the side effects of total ablative lasers. Recently, the fractional CO 2 laser followed by topical steroids combined with NB-UVB or sun exposure has been proved to be effective in the treatment of refractory vitiligo [12,13]. In 2015, we also reported a triple combination treatment with fractional CO 2 laser assisting delivery of topical betamethasone solution plus NB-UVB phototherapy for refractory vitiligo and achieved some encouraging results [14].…”

Section: Discussionmentioning

confidence: 96%

“…Three months posttreatment (M3) and 6 months post-treatment (M6), the response to the treatment was assessed by two blinded dermatologists. Depending on the extent of re-pigmentation, the response to the treatment was graded as: no or minimal (<25%), moderate (25-49%), marked (50-74%), excellent (≥75%) [12,13]. Any side effect was recorded during the procedure.…”

Section: Measurementmentioning

confidence: 99%

“…This characteristic facilitates the skin healing process. Recently, fractional CO 2 laser was reported to be used in the treatment of refractory vitiligo followed by NB-UVB or sun exposure [12,13]. In 2015, we reported a triple combination treatment with fractional CO 2 laser assisting delivery of topical betamethasone solution plus NB-UVB phototherapy for refractory vitiligo and achieved some preliminary and encouraging results [14].…”

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confidence: 99%

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Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

et al. 2017

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Resistant non-segmental vitiligo is difficult to be treated. Ablative erbium-YAG (Er:YAG) laser has been used in the treatment of vitiligo, but the ablation of entire epidermis frustrated the compliance of patients. The purpose of this study is to investigate the effects of fractional Er:YAG laser followed by topical betamethasone and narrow band ultraviolet B (NB-UVB) therapy in the treatment of resistant nonsegmental vitiligo. The vitiligo lesions of each enrolled patient were divided into four treatment parts, which were all irradiated with NB-UVB. Three parts were, respectively, treated with low, medium, or high energy of Er:YAG laser, followed by topical betamethasone solution application. A control part was spared with laser treatment and topical betamethasone. The treatment period lasted 6 months. The efficacy was assessed by two blinded dermatologists. Treatment protocol with high energy of 1800 mJ/P of fractional Er:YAG laser followed by topical betamethasone solution and in combination with NB-UVB made 60% patients achieve marked to excellent improvement in white patches. The protocol with medium energy of 1200 mJ/P of laser assisted approximate 36% patients achieve such improvement. The two protocols, respectively, showed better efficacies than NB-UVB only protocol. However, fractional Er:YAG laser at low energy of 600 mJ/P did not provide such contributions to the treatment of vitiligo. The fractional Er:YAG laser in combination with topical betamethasone solution and NB-UVB was suitable for resistant non-segmental vitiligo. The energy of laser was preferred to be set at relatively high level.

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Section: Discussionmentioning

confidence: 96%

Section: Measurementmentioning

confidence: 99%

mentioning

confidence: 99%

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Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

et al. 2017

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“…18,19 This probably recruits the adjacent melanocytes into the treated area and melanogenesis might be promoted. 16,17 Furthermore, in treating IGH lesions, dysfunctional 6.67% 1.67% 3.33% 6.67% P < 0.01 Figure 2 The improvement score evaluated by dermatologists. Figure 3 The patients' self-assessment score after the last treatment.…”

Section: Discussionmentioning

confidence: 98%

Non‐ablative fractional photothermolysis in treatment of idiopathic guttate hypomelanosis

Rerknimitr

Chitvanich

Pongprutthipan

et al. 2014

Acad Dermatol Venereol

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“…Eine weitere aktuell vorgestellte Kombinationstherapie besteht aus der Verwendung eines fraktionierten CO 2 -Lasers, ergänzt durch eine Schmalband-UVB-Therapie zur Behandlung der Vitiligo [48]. In einer prospektiven, randomisierten Halbseitenvergleichsstudie wurde die komplementäre Anwendung beider Therapieformen an Patienten (n = 10) mit nichtsegmentaler, therapierefraktärer Vitiligo erprobt.…”

Section: Fraktionale Lasertherapieunclassified

Neue Entwicklungen in der Lasertherapie

Babilas

Landthaler

2012

Hautarzt

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Based on the theory of stimulated emission of radiation that was proposed by Albert Einstein in 1916, the first lasers were developed in the 1960s. The first clinical use of laser technology in a German university took place in 1978 in the Department of Dermatology of the Ludwig-Maximilian-University in Munich under the guidance of the former director, Prof. Dr. med. Dr. h.c. mult. Otto Braun-Falco. In the following years, laser technology developed rapidly. Today laser technology is a widely used interdisciplinary therapeutic procedure that has deep clinical and scientific roots in dermatology. There are many conditions in both classic and aesthetic dermatology that are routinely - and sometimes exclusively - treated with lasers. Here we review recent developments in laser medicine. There seems to be a trend to combination procedures. To enhance efficacy, different laser systems are together or lasers are combined with specific topical medications.

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Combination treatment by 10 600 nm ablative fractional carbon dioxide laser and narrowband ultraviolet B in refractory nonsegmental vitiligo: a prospective, randomized half-body comparative study

Abstract: This study suggests that fractional CO(2) laser therapy followed by NB-UVB phototherapy could be used effectively and safely as an alternative modality for the treatment of refractory vitiligo.

Cited by 81 publications

References 11 publications

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo

Non‐ablative fractional photothermolysis in treatment of idiopathic guttate hypomelanosis

Neue Entwicklungen in der Lasertherapie

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