Combination treatment with Gua Sha and Blood-letting causes attenuation of systemic inflammation, activated coagulation, tissue ischemia and injury during heatstroke in rats

Tu, Wenzhan; Cheng, Ruidong; Hu, Jie; Wang, Jie-zhi; Lin, Haiyan; Zou, En-miao; Wang, Wansheng; Lou, Xinfa; Jiang, Songhe

doi:10.1007/s11655-014-1816-4

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…PT, APTT and D-dimer were markers reflecting coagulation function (36). Results showed that the values of PT in HSGSK were shorter than those in HS or HS-Pre-GSK (p = 0.019, p = 0.027; respectively; Fig 4B).…”

Section: Gsk2193874 Treatment At Heatstroke Onset Attenuated Coagulation Dysfunctionmentioning

confidence: 88%

“…Heatstroke induces coagulation dysfunction. The histochemical result shows disseminating intravascular coagulation, which then promotes organ failure and induces death (36). Prothrombin time (PT), activated partial thromboplastin time (APTT) and D-dimer are used as markers reflecting disseminating intravascular coagulation (36).…”

Section: Discussionmentioning

confidence: 99%

“…The histochemical result shows disseminating intravascular coagulation, which then promotes organ failure and induces death (36). Prothrombin time (PT), activated partial thromboplastin time (APTT) and D-dimer are used as markers reflecting disseminating intravascular coagulation (36). In HSGSK group, GSK2193874 treatment at heatstroke onset significantly reduced the value of PT, APTT or D-dimer compared with HS or HS-Pre-GSK group (Fig 4B , C and D), and improved coagulation dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice

Chen

Pei

2018

Cell Mol Biol (Noisy-le-grand)

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Heatstroke is still a potentially fatal threat during summer heat waves, despite improved prevention and treatment. It is reported that the transient receptor potential vanilloid 4 (TRPV4) inhibitor may protect septicemia mice. Many aspects of heatstroke have been defined, from the sepsis-mimic inflammatory response to hyperthermia. Hence, TRPV4 may be a therapeutic target for heatstroke. The results in murine models of heatstroke verified that GSK2193874, as a selected TRPV4 inhibitor, was injected at heatstroke onset, and then reduced the reduction of core temperature, the death rate, wet/dry ratio of the lung, levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, coagulation indicators, the degree of organ injury, and caspase-3/7 activity (P<0.05). But GSK2193874 treatment before heat stress did not improve the symptoms of heatstroke mice. Therefore, TRPV4 should be involved in heatstroke-induced injury. Timely GSK2193874 administration may be useful to reduce heatstroke-induced injury. TRPV4 may be a potential new therapeutic target in fatal heatstroke.

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Section: Gsk2193874 Treatment At Heatstroke Onset Attenuated Coagulation Dysfunctionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice

Chen

Pei

2018

Cell Mol Biol (Noisy-le-grand)

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“… 15 Research has indicated that Gua Sha therapy may enhance immune response and anti-inflammatory effects. 30 The pressure stimulation of Gua Sha on the skin leads to subcutaneous capillary rupture, with resultant blood leakage acting as a stimulus, initiating local aseptic inflammation response. 22 Our finding showed that the Gua Sha group exhibited increased plasma levels of 5-HT and IL-10, and decreased levels of IL-8 compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Gua Sha Therapy on Pain in Parkinson’s Disease: a Randomized Controlled Trial

Xu,

Wang,

Chen

et al. 2024

IJGM

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“…Additionally, acupuncture can improve blood distribution throughout the body Acupuncture can enhance blood circulation in the skin, increase heat dissipation, and regulate blood distribution in the visceral organs. Research has shown that Gua sha combined blood-letting after HS can improve survival by reducing systemic inflammation, hypercoagulable states, tissue ischemia, and multiple organ damage ( Aprile et al, 2015 ; Tu et al, 2015 ). XNJI combined with acupuncture on HS could help reduce the recovery time of consciousness and alleviate the injury of organs.…”

Section: External Therapies Against Hsmentioning

confidence: 99%

Therapeutic potential of traditional Chinese medicine on heat stroke

Li,

Wang,

Chen

et al. 2023

Front. Pharmacol.

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As global warming progresses, heat waves are becoming increasingly frequent and intense, meanwhile the incidence of heat stroke (HS) has increased sharply during the past decades. HS is typically associated with significant morbidity and mortality, and there is an urgent need for further research to solve this difficult issue. There currently exists difficulties regarding on-site emergency treatment methods and limited in-hospital treatment approaches, and better treatments are required as soon as possible. Theories and therapies from various traditional Chinese medicine (TCM) academic groups have been widely reported. Therefore, an exploration of prevention and protection methods should consider TCM experiences as an alternative. This article primarily reviews TCM herbal therapies and external therapies that have been described in various clinical reports and demonstrated in relevant studies. Herbal therapies, including herbal formulas, Chinese patent medicines (CPMs), single Chinese herbs, and associated extracts or monomers, are summarized based on the shared perspectives of the underlying mechanisms from TCM. In addition, external therapies including acupuncture, bloodletting, cupping, Gua sha and Tui na that have rarely been rarely mentioned and considered in most cases, are introduced and discussed to offer a unique perspective in the search for novel interventions for HS. In summary, TCM may provide abundant potential clinical benefits and research directions in the fight against HS.

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Combination treatment with Gua Sha and Blood-letting causes attenuation of systemic inflammation, activated coagulation, tissue ischemia and injury during heatstroke in rats

Abstract: Gua Sha combined with Blood-letting after heatstroke may improve survival by ameliorating systemic inflflammation, hypercoagulable state, and tissue ischemia and injury in multiple organs.

Cited by 4 publications

References 23 publications

GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice

GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice

The Effect of Gua Sha Therapy on Pain in Parkinson’s Disease: a Randomized Controlled Trial

Therapeutic potential of traditional Chinese medicine on heat stroke

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