Combinatorial design of multimeric chelating peptoids for selective metal coordination

Ricano, Abel; Captain, Ilya; Carter, Korey P.; Nell, Bryan P.; Deblonde, Gauthier J.‐P.; Abergel, Rebecca J.

doi:10.1039/c9sc01068h

Cited by 21 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also synthesized the octa-dentate ligands 3,4,3-LI(1,2-HOPO) 2 (CAM) 2 and 3,4,3-LI(CAM) 2 (1,2-HOPO) 2 , and studied their thermodynamic and photophysical properties with Eu 3+ and Tb 3+ . Both ligands showed high affinity for Ln(III) ion, and their stability constant of Eu(III) complex is greater than 10 29 [73].…”

Section: Multidentate Hydroxypyridinonesmentioning

confidence: 97%

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Zhou¹,

Dong²,

Shen

2021

Molecules

View full text Add to dashboard Cite

Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years. This review article focuses on how multidentate HOPOs can be used in targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals. The general structure of radiometal-based targeted radiopharmaceuticals, a brief description of siderophores, the basic structure and properties of bidentate HOPO, some representative HOPO multidentate chelating agents, radiopharmaceuticals based on HOPO multidentate bifunctional chelators for gallium-68, thorium-227 and zirconium-89, as well as the future prospects of HOPO multidentate bifunctional chelators in other metal-based radiopharmaceuticals are described and discussed in turn. The HOPO metal-based radiopharmaceuticals that have shown good prospects in clinical and preclinical studies are gallium-68, thorium-227 and zirconium-89 radiopharmaceuticals. We expect HOPO multidentate bifunctional chelators to be a very promising platform for building novel targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals.

show abstract

Section: Multidentate Hydroxypyridinonesmentioning

confidence: 97%

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Zhou¹,

Dong²,

Shen

2021

Molecules

View full text Add to dashboard Cite

show abstract

“…A new library of 16 octadentate peptoids based on hydroxypyridinone (1,2-HP) and cathecolamide sub-monomer units was developed for chelation of f-block metals (luminescence and thermodynamic solution studies with Eu 3+ and Tb 3+ ), by using a precision and systematic design approach with a solid-support synthesis [ 88 ]. This type of synthesis revealed to be a good investment for tailoring compounds towards efficient separation of f -elements (e.g., log β EuL = 43.97 for L30 ).…”

Section: Poly-hydroxypyridinonesmentioning

confidence: 99%

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

et al. 2022

View full text Add to dashboard Cite

Hydroxypyridinones (HPs) are recognized as excellent chemical tools for engineering a diversity of metal chelating agents, with high affinity for hard metal ions, exhibiting a broad range of activities and applications, namely in medical, biological and environmental contexts. They are easily made and functionalizable towards the tuning of their pharmacokinetic properties or the improving of their metal complex thermodynamic stabilities. In this review, an analysis of the recently published works on hydroxypyridinone-based ligands, that have been mostly addressed for environmental applications, namely for remediation of hard metal ion ecotoxicity in living beings and other biological matrices is carried out. In particular, herein the most recent developments in the design of new chelating systems, from bidentate mono-HP to polydentate multi-HP derivatives, with a structural diversity of soluble or solid-supported backbones are outlined. Along with the ligand design, an analysis of the relationship between their structures and activities is presented and discussed, namely associated with the metal affinity and the thermodynamic stability of the corresponding metal complexes.

show abstract

“…They found the peptoid scaffold to be a readily accessible, versatile platform for the future development of efficient lanthanide ligands. 158 Besides chelation of single metals, OBOC libraries were employed to identify peptoid ligands of multimetallic clusters such as the [Co Sing et al attempted to bridge metal chelation and biological activity with the help of OBOC libraries. As a proof of principle, they designed a large library consisting of the potent metal chelator 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid (DOTA) and three corresponding peptoid oligomers (Figure 7).…”

Section: Figurementioning

confidence: 99%

Bio-instructive materials on-demand – combinatorial chemistry of peptoids, foldamers, and beyond

et al. 2021

View full text Add to dashboard Cite

show abstract

Combinatorial design of multimeric chelating peptoids for selective metal coordination

Abstract: The combinatorial synthesis of a new library of tetrameric peptoid ligands is introduced, enabling coordination and characterization of f-block metals.

Cited by 21 publications

References 39 publications

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

Bio-instructive materials on-demand – combinatorial chemistry of peptoids, foldamers, and beyond

Contact Info

Product

Resources

About