Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach

Bejeshk, Mohammad-Abbas; Joukar, Siyavash; Shahouzehi, Beydolah; Asadi-shekari, Majid; Rajizadeh, Mohammadamin; Raji-Amirhasani, Alireza; Naderi-Boldaji, Vida

doi:10.1016/j.artres.2018.10.226

Cited by 17 publications

(6 citation statements)

References 42 publications

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“…There is evidence that low-intensity endurance exercise plus BFR alters the expression of cardiac apelin receptors, leading to hypertrophy and ventricular conduction in older mice. It has also been shown that low-intensity exercise alone increases apelin receptor expression, but exercise with BFR increases apelin receptor expression more than exercise alone ( 167 , 168 ). Therefore, further studies are needed to clarify the effect of resistance training with BFR on adipokines in people with sarcopenic obesity.…”

Section: The Effect Of Blood Flow Restriction (Bfr) Exercises On Sarc...mentioning

confidence: 99%

Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors

Pahlavani

2022

Front. Endocrinol.

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Sarcopenic obesity is defined as a multifactorial disease in aging with decreased body muscle, decreased muscle strength, decreased independence, increased fat mass, due to decreased physical activity, changes in adipokines and myokines, and decreased satellite cells. People with sarcopenic obesity cause harmful changes in myokines and adipokines. These changes are due to a decrease interleukin-10 (IL-10), interleukin-15 (IL-15), insulin-like growth factor hormone (IGF-1), irisin, leukemia inhibitory factor (LIF), fibroblast growth factor-21 (FGF-21), adiponectin, and apelin. While factors such as myostatin, leptin, interleukin-6 (IL-6), interleukin-8 (IL-8), and resistin increase. The consequences of these changes are an increase in inflammatory factors, increased degradation of muscle proteins, increased fat mass, and decreased muscle tissue, which exacerbates sarcopenia obesity. In contrast, exercise, especially strength training, reverses this process, which includes increasing muscle protein synthesis, increasing myogenesis, increasing mitochondrial biogenesis, increasing brown fat, reducing white fat, reducing inflammatory factors, and reducing muscle atrophy. Since some people with chronic diseases are not able to do high-intensity strength training, exercises with blood flow restriction (BFR) are newly recommended. Numerous studies have shown that low-intensity BFR training produces the same increase in hypertrophy and muscle strength such as high-intensity strength training. Therefore, it seems that exercise interventions with BFR can be an effective way to prevent the exacerbation of sarcopenia obesity. However, due to limited studies on adipokines and exercises with BFR in people with sarcopenic obesity, more research is needed.

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Section: The Effect Of Blood Flow Restriction (Bfr) Exercises On Sarc...mentioning

confidence: 99%

Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors

Pahlavani

2022

Front. Endocrinol.

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“…One‐way ANOVA and Tukey's post hoc test were used to investigate the significant differences in the levels of the relevant variables in the research groups. The significance level was considered as P < 0.05 (Bejeshk et al., 2018 ; Rajizadeh, Aminizadeh et al., 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Rajizadeh,

Hosseini,

Bahrami

et al. 2023

Experimental Physiology

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Methotrexate (Mtx) is used to treat various diseases, including cancer, arthritis and other rheumatic diseases. However, it induces oxidative stress and pulmonary inflammation by stimulating production of reactive oxygen species and cytokines. Considering the positive effects of physical activity, our goal was to investigate the preventive and therapeutic role of continuous training (CT) on Mtx‐induced lung injury in rats. The rats were divided into five groups of 14 animals: a control group (C); a continuous exercise training group (CT; healthy rats that experienced CT); an acute lung injury with Mtx group (ALI); a pretreatment group with CT (the rats experienced CT before ALI induction), and a post‐treatment group with CT (the rats experienced CT after ALI induction). One dose of 20 mg/kg Mtx intraperitoneal was administered in the Mtx and training groups. Forty‐eight hours after the last exercise session all rats were sacrificed. According to our results, the levels of tumour necrosis factor‐α (TNF‐α), malondialdehyde (MDA), myeloperoxidase (MPO), GATA binding protein 3 (GATA3) and caspase‐3 in the ALI group significantly increased compared to the control group, and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), interleukin‐10 (IL‐10), forkhead box protein 3 (FOXP3), and T‐bet decreased. In contrast, compared to the acute lung injury group, pretreatment and treatment with CT reduced TNF‐α, MDA, MPO, GATA3 and caspase‐3 and increased SOD, GPX, TAC, IL‐10, FOXP3 and T‐bet levels. The effects of CT pretreatment were more significant than the effects of CT post‐treatment. Continuous exercise training effectively reduced oxidative stress and inflammatory cytokines and ameliorated Mtx‐induced injury, and the effects of CT pretreatment were more significant than the effects of CT post‐treatment.New Findings What is the central question of this study? Considering the high prevalence of lung injury in society, does exercise as a non‐pharmacological intervention have ameliorating effects on lung injury? What is the main finding and its importance? Exercise can have healing effects on the lung after pulmonary injury through reducing inflammation, oxidative stress and apoptosis. Considering the lower side effects of exercise compared to drug treatments, the results of this study may be useful in the future.

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“…The colon tissue was homogenized in 6 buffer volumes of 10 mM HEPES, 10 mM KCl, 0.5 mM sucrose, 1 mM EGTA, 1 mM DTT, and 250 μl lysis buffer. The homogenates were then centrifuged at 750 g for 10 min, and the supernatant was stored at −70 °C for evaluations [ 51 ].…”

Section: Methodsmentioning

confidence: 99%

Ameliorating effects of Acacia arabica and Ocimum basilicum on acetic acid-induced ulcerative colitis model through mitigation of inflammation and oxidative stress

Bejeshk,

Aminizadeh,

Rajizadeh

et al. 2023

Heliyon

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Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach

Cited by 17 publications

References 42 publications

Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors

Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate

Ameliorating effects of Acacia arabica and Ocimum basilicum on acetic acid-induced ulcerative colitis model through mitigation of inflammation and oxidative stress

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