Combinatorial Libraries: Studies in Molecular Recognition and the Quest for New Catalysts

Abstract

Combinatorial libraries offer a new powerful tool for gathering empirical information about host/guest interactions and for developing catalysts for organic reactions. Combinatorial approaches to molecular recognition are discussed, i.e. torial approaches are also reviewed. screening of libraries of ligands with synthetic receptors and libraries of synthetic receptors with the ligands for which selective binding is desired. Recent achievements in the development of new catalysts for organic synthesis using combina-

Rapid screening and combinatorial methods in homogeneous organometallic catalysis

“…The principles of combinatorial chemistry have been covered in several recent monographs and reviews [11][12][13][14][15][16]. In summary, the concept involves creating a large number of chemically distinct species-called a library-in a controlled way.…”

“…The number of peptides increases very dramatically as we move to two, three, and four variable positions: these choices give 8000, 160 000, and 3.2 × 10 6 members, at least theoretically speaking. We leave aside the problem of deconvoluting the library to determine which member was responsible for any hit, but these issues are discussed in the literature [4][5][6][7][11][12][13][14][15][16].…”

“…The latest methods of computational and theoretical chemistry can give very valuable mechanistic information in ruling out otherwise plausible pathways and predicting structural information for transient species and transition states [10]. Here, we naturally discuss only the title topic, although by doing so we do not intend to detract from the importance of mechanistic understanding.The principles of combinatorial chemistry have been covered in several recent monographs and reviews [11][12][13][14][15][16]. In summary, the concept involves creating a large number of chemically distinct species-called a library-in a controlled way.…”

Efficient Assays for Combinatorial Methods for the Discovery of Catalysts

“…[7] In homogeneous molecular chemistry, where discrete building blocks can be assembled, several recent examples of automated or semiautomated catalyst discovery have been reported. [8,9] Different core structures have been assembled on beads, and diversity was introduced by the attachment of combinations of building blocks to the cores. Several of these systems were then metalated and resulted in a set of catalyst candidates.…”

Effiziente Assays für kombinatorische Methoden zur Entdeckung von Katalysatoren

“…Kürzlich wurden in dieser Disziplin einige Beispiele für die automatisierte oder halbautomatisierte Entdeckung von Katalysatoren beschrieben. [8,9] Mehrere Grundstrukturen wurden auf Kugeln zusammengefügt, wobei durch Anbindung von Bausteinkombinationen an diese Grundstrukturen Diversität erreicht wurde. Einige dieser Systeme wurden dann metalliert, was zu einer Auswahl möglicher Katalysatoren führte.…”