Combinatorial Molecular Imprinting:  An Approach to Synthetic Polymer Receptors

The rational development of molecularly imprinted polymer-based sensors for protein detection

“…22 In combinatorial approaches the best composition is selected on the basis of simultaneous synthesis and testing of tens to hundreds of imprinted polymers prepared on a small scale. [23][24][25] In the computational approach the monomer screening is performed virtually. 26,27 These two approaches permit the creation of MIPs with affinities and selectivities comparable to those of antibodies, 26 ( Table 2).…”

“…[136][137][138] Alternatively a rational selection can be made, either using a combinatorial (experimental) approach, 23,24 a chemometric experimental design 24 or by computational methods. be unwise to use it the production of MIPs, since biomolecules are highly likely to undergo conformational changes 143 such that the resulting imprint will not be representative of the native protein target in aqueous solution, where the sensor is most likely to be required to perform.…”

Chiral separation by chromatographic and electromigration techniques. A Review

“…Recently, methods for combinatorial synthesis and screening of a series of MIPs have been described [187,188]. Monolithic MIPs were prepared by in situ polymerization in the column [189][190][191].…”

Influence of salt ions on binding to molecularly imprinted polymers

“…More recently, several promising methods to approach the optimization problem in a more systematic way have been demonstrated. Chemometrical approaches, combinatorial synthesis, high-throughput screening, and computational methods have been applied to investigate factors of importance in the synthesis protocol and to expedite the optimization of polymer compositions towards high selective rebinding of the template [4][5][6][7][8][9][10][11][12][13][14][15].…”