1998
DOI: 10.1101/gad.12.24.3910
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Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm

Abstract: Mesodermal progenitors arise in theDuring animal development, a wide diversity of cellular identities must be specified within initially undifferentiated fields of cells. One solution to this problem is for a hierarchy of regulators to promote the progressive determination of cells, essentially carving out from the original field domains with increasingly restricted developmental potential. In such a mechanism, spatially localized factors first delineate a prepattern in which all cells are equally competent to… Show more

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Cited by 185 publications
(205 citation statements)
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“…As mesoderm migration and specification of EVE-positive mesoderm cells occur normally in stg mutant embryos, this mutation provides a genetic condition to assay cytokinesis-independent functions of pbl (Fig. 4B,E) (Carmena et al, 1998;Leptin and Grunewald, 1990). The cytokinesis defect of pbl was completely blocked by stg (Fig.…”
Section: Cell Shape Changes During Mesoderm Migrationmentioning
confidence: 99%
See 1 more Smart Citation
“…As mesoderm migration and specification of EVE-positive mesoderm cells occur normally in stg mutant embryos, this mutation provides a genetic condition to assay cytokinesis-independent functions of pbl (Fig. 4B,E) (Carmena et al, 1998;Leptin and Grunewald, 1990). The cytokinesis defect of pbl was completely blocked by stg (Fig.…”
Section: Cell Shape Changes During Mesoderm Migrationmentioning
confidence: 99%
“…The most dorsal mesodermal fates are controlled by combinatorial action of multiple signaling pathways and intrinsic factors. These inputs govern the formation of a subset of dorsal mesodermal derivatives, marked by the expression of even skipped (eve) (Carmena et al, 1998;Halfon et al, 2000;Knirr and Frasch, 2001). In mutants in which mesoderm migration is affected, e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Genetic studies highlight the essential role of the regulatory inputs, which set up the cell fate-specifying combinatorial code of transcription factor activities, the identity gene code (Carmena et al 1998;Halfon et al 2000;Jagla et al 2002;Zaffran and Frasch 2002;Liu et al 2006;Estrada et al 2006). The identity gene code is commonly used to ensure diversification of cells in a broad range of developing tissues and metazoan organisms (Briscoe et al 2000;Jagla et al 2002;Buckingham 2003;De Graeve et al 2004;Certel and Thor 2004).…”
mentioning
confidence: 99%
“…Following mesodermal subdivision, somatic myogenesis proceeds within the high Twist domain. Wingless signaling leads to the specification of groups of equipotent myoblasts, which express the gene lethal of scute (Carmena et al, 1995;Carmena et al, 1998). While all cells within an equivalence group have the potential to develop into a muscle progenitor, lateral inhibition, mediated by Notch signaling, leads to the selection of one progenitor per group (Bate et al, 1993;Carmena et al, 2002;Corbin et al, 1991).…”
Section: Introductionmentioning
confidence: 99%