Combined alternating current electrothermal and dielectrophoresis-induced tunable patterning to actuate on-chip microreactions and switching at a floating electrode

Sun, Haizhen; Ren, Yukun; Tao, Ye; Liu, Weiyu; Jiang, Tianyi; Jiang, Hongyuan

doi:10.1016/j.snb.2019.127397

Cited by 17 publications

(19 citation statements)

References 45 publications

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“…108 Finally, a key motivation for nanoscale electrochemistry is that measurements made on ensembles obscure the heterogeneity extant among single entities, [109][110][111] such as individual cells, enzymes, nanoparticle catalysts, 114,115 or nanobubbles. [116][117][118][119] This variability is not only meaningful, but can also dominate the behavior of the ensemble. These diverse areas of impact, coupled with the eminent scalability of BPEs, have motivated the development of bipolar electrochemistry at the nanoscale.…”

Section: Nanoscale Bipolar Electrochemistrymentioning

confidence: 99%

“…In two publications, Jiang and coworkers demonstrated that one BPE located along the length of a microchannel, and polarized in the transverse direction, generates an axial electric field minimum (along its centerline) and maxima (along its edges). 116,135 Similarly, two…”

Section: Dielectrophoretic Techniques Using Bpesmentioning

confidence: 99%

“…For example, nanoscale electrodes provide the resolution necessary to observe the millisecond-scale release of catecholamines from a single chromaffin cell. , Further, nanoconfinement leads to the formation of steep gradients in electrical potential and chemical species concentrations that can drive rapid or selective mass transport, which has been leveraged for kinetic measurements, chemical separations, and charge storage applications . Finally, a key motivation for nanoscale electrochemistry is that measurements made on ensembles obscure the heterogeneity extant among single entities, − such as individual cells, enzymes, nanoparticle catalysts, , or nanobubbles. − This variability is not only meaningful, but can also dominate the behavior of the ensemble. These diverse areas of impact, coupled with the eminent scalability of BPEs, have motivated the development of bipolar electrochemistry at the nanoscale. − …”

Section: Nanoscale Bipolar Electrochemistrymentioning

confidence: 99%

“…Recent contributions to the field of DEP using BPEs include advances in methods employed for the individual isolation and analysis or continuous sorting of cells, beads, or droplets. ,,− In 2017, our group interconnected up to 32 parallel microfluidic channels with an underlying array of BPEs, with tips aligned to cell-sized micropockets, for high-fidelity isolation of individual tumor cells . Blood cells were repelled from the BPEs and flowed through unimpeded to the outlet.…”

Section: Dielectrophoretic Techniques Using Bpesmentioning

confidence: 99%

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Recent Advancements in Bipolar Electrochemical Methods of Analysis

Rahn

Anand

2020

Anal. Chem.

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The goal of this review is to provide an overview of the advancements made in the field of bipolar electrochemistry over the past 2 years, with an emphasis on analysis. Bipolar electrodes (BPEs) are versatile, and in electroanalysis, they have been used extensively to screen electrocatalysts(1−4) and to sense biomarkers.(5−10) Their ability to modulate local electric fields lends them to the manipulation of cells and to the enrichment and separation of analytes.(11−17) Finally, by virtue of the polar and often graded profile of the interfacial potential across BPEs, they provide a platform for synthesis of Janus particles, useful as sensors and as microswimmers(18−22) and other materials with compositional gradients.(23,24) BPEs are particularly well-suited to analytical challenges that demand multiplexing or amenability to point-of-need (PON) application because even large arrays of BPEs can be controlled with simple equipment yet yield quantitative information about a system. In this review, we discuss recent progress in reactions that transduce current to a visible signal, sensing mechanisms, bipolar electrochemical cell design, integration of bipolar electrochemistry with spectroscopic techniques, BPEs at the nanoscale, and the application of BPEs to electrokinetics and materials preparation. Throughout the discussion, we identify promising trends, innovative directions, and remaining challenges in the field. Disciplines Disciplines Analytical Chemistry Comments Comments

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Section: Nanoscale Bipolar Electrochemistrymentioning

confidence: 99%

Section: Dielectrophoretic Techniques Using Bpesmentioning

confidence: 99%

Section: Nanoscale Bipolar Electrochemistrymentioning

confidence: 99%

Section: Dielectrophoretic Techniques Using Bpesmentioning

confidence: 99%

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Recent Advancements in Bipolar Electrochemical Methods of Analysis

Rahn

Anand

2020

Anal. Chem.

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“…As the core conductivity decreases, the positive DEP zone recedes from the left at a frequency around 1 MHz. In addition to lateral movement from DEP, the droplet also undergoes deformation and electrohydrodynamic flow due to interfacial Maxwell stress from accumulation of charges at the droplet interfaces, which has been investigated thoroughly elsewhere [ 29 , 30 ]. In this work, we observed that under the experimental conditions the droplet deformation or induced flow was negligible.…”

Section: Experimental Setup and Theorymentioning

confidence: 99%

Dielectrophoresis Response of Water-in-Oil-in-Water Double Emulsion Droplets with Singular or Dual Cores

et al. 2020

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Microfluidic technologies have enabled generation of exquisite multiple emulsion droplets, which have been used in many fields, including single-cell assays, micro-sized chemical reactions, and material syntheses. Electrical controlling is an important technique for droplet manipulation in microfluidic systems, but the dielectrophoretic behaviors of multiple emulsion droplets in electrical fields are rarely studied. Here, we report on the dielectrophoresis response of double emulsion droplets in AC electric fields in microfluidic channel. A core-shell model is utilized for analyzing the polarization of droplet interfaces and the overall dielectrophoresis (DEP) force. The water-in-oil-in-water droplets, generated by glass capillary devices, experience negative DEP at low field frequency. At high frequency, however, the polarity of DEP is tunable by adjusting droplet shell thickness or core conductivity. Then, the behavior of droplets with two inner cores is investigated, where the droplets undergo rotation before being repelled or attracted by the strong field area. This work should benefit a wide range of applications that require manipulation of double emulsion droplets by electric fields.

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Tuning AC Electrokinetic Flow to Enhance Nanoparticle Accumulation in Low‐Conductivity Solutions

Abdelghany,

Ichikawa,

Motosuke

2023

Adv Materials Inter

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This study presents a novel AC electrokinetics‐based microfluidic approach for nanoparticle trapping and accumulation in low‐conductive aqueous solutions. The concentration performance is systematically investigated by tuning the applied voltage and frequency, showing that AC electrothermal flow (ACET)‐induced vortex trapping provides a field strength‐dependent concentration enhancement and a high concentration factor. The findings reveal a substantial enhancement in the concentration of polystyrene nanoparticles with sizes of 100 nm. Specifically, a 16‐fold enrichment in the concentration is achieved compared with the initial concentration of the sample. In addition, the effectiveness of a high‐frequency AC voltage (50–150 kHz) versus a low‐frequency accumulation (1–20 kHz) for nanoparticle accumulation is compared and it is determined that at high frequencies, the trapped nanoparticles accumulate at a single area at the electrode gap, which differs from the low‐frequency accumulation observed in previous studies. The complex behavior of nanoparticle accumulation is analyzed, including the differences in the hydrodynamic flow patterns between AC electroosmosis and ACET flow. The proposed technique provides a powerful tool for the efficient and controllable manipulation of nanoparticles and contributes to a highly sensitive characterization of nanomaterials in low‐conductivity liquid samples in microfluidic systems through efficient particle trapping.

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Combined alternating current electrothermal and dielectrophoresis-induced tunable patterning to actuate on-chip microreactions and switching at a floating electrode

Cited by 17 publications

References 45 publications

Recent Advancements in Bipolar Electrochemical Methods of Analysis

Recent Advancements in Bipolar Electrochemical Methods of Analysis

Dielectrophoresis Response of Water-in-Oil-in-Water Double Emulsion Droplets with Singular or Dual Cores

Tuning AC Electrokinetic Flow to Enhance Nanoparticle Accumulation in Low‐Conductivity Solutions

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