Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells

Abstract

Honokiol combined with rosiglitazone showed more effective growth inhibition in hepatoma cells mediated through the regulation of G0/G1 phase-related proteins p21, cyclin D1, cyclin E1, and Rb and cell cycle progression.

Honokiol-loaded polymeric nanoparticles: an active targeting drug delivery system for the treatment of nasopharyngeal carcinoma

“…Although HK antitumor effects might not be explained by a single mechanism, our results clearly showed multiple antitumor pharmacological effects leading to cell cycle arrest, apoptosis, micro-vessels production, and proliferation suppression (Hahm & Singh, 2007 ; Fang et al, 2009 ; Cheng et al, 2016 ). Previous studies showed that HK can inhibit carcinoma cells growth through inducing G 0 /G 1 phase cell cycle arrested (Arora et al, 2011 ; Chen et al, 2016 ; Hahm et al, 2016 ). Our cell-cycle study showed that ATNH remarkable increased the number of cells in G 1 phase, as shown by precious studies.…”

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“…Magnolol has been also suggested to exert a benzodiazepinelike sleep-promoting effect by acting on the GABA A receptor, known to be modulated by traditional benzodiazepines as well as nonbenzodiazepine hypnotic drugs which are the first line pharmacological agents used to treat insomnia [58]. These findings suggest that the ability of magnolol to increase the effect of drugs interacting with GABA A receptors should not be excluded.…”

“…Numerous studies reported that PPARγ agonists, due to their ability to induce cell growth inhibition, cell cycle arrest, or apoptosis of tumor cells, act also as antitumoral agents [64]. Recently, it has been reported that honokiol too exerted an antiproliferative effect on hepatoma cells through the regulation of G0/G1 phaserelated proteins expression and that a more effective inhibition was induced when honokiol was administered with rosiglitazone [58].…”