Combined Effects of Halothane Anesthesia and Verapamil on Systemic Hemodynamics and Left Ventricular Myocardial Contractility in Patients with Ischemic Heart Disease

Schulte-Sasse, U.; Hess, Wolfgang R.; Markschies-Hornung, Alexandra; Tarnow, J.

doi:10.1213/00000539-198409000-00002

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Calcium-channel Blockers1

Halogenated Anaesthetics1

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1988

2003

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Cited by 24 publications

(2 citation statements)

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“…Given the additive effects of general anesthetics and calcium-channel blockers in reducing left ventricular dP/dT and decreasing afterload, one should be careful in using this combination of drugs in patients with impaired cardiac function or hypovolemia. 15, 16 The PR interval should also be carefully monitored in these patients.…”

Section: Calcium-channel Blockersmentioning

confidence: 99%

Pharmacotherapeutic Considerations in Anesthesia

Amar

2003

Heart Disease

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This article focuses on new findings leading to improved understanding of the pathophysiology and mechanisms of potential drug interactions between anesthetic drugs or techniques and cardiovascular medications in patients scheduled for surgery. Only the most frequently used drugs are reviewed. Elective surgery provides the luxury to consider these risks and alter therapy accordingly. Under urgent circumstances, however, the increased risks associated with these agents should be anticipated with the goal to minimize adverse effects while maintaining optimal cardiovascular function in the perioperative period.

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Section: Calcium-channel Blockersmentioning

confidence: 99%

Pharmacotherapeutic Considerations in Anesthesia

Amar

2003

Heart Disease

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“…SchulteSasse et al 136 showed that verapamil 0.15 mg. kg -t IV was well tolerated during anaesthesia with low inspired concentrations of halothane (0.35 per cent) in CAD patients. The IV administration of verapamil may be hazardous in some circumstances.…”

Section: Halogenated Anaestheticsmentioning

confidence: 99%