Combined exposure to multiple dioxins and dioxin-like polychlorinated biphenyls on hypertension among US adults in NHANES: a cross-sectional study under three statistical models

Wu, Birong; Guo, Xianwei; Feng, Linya; Gao, Juan; Xia, Weihang; Xie, Peng; Ma, Shaodi; Liu, Haixia; Zhao, Dongdong; Qu, Guangbo; Sun, Chenyu; Lowe, Scott W.; Bentley, Rachel; Sun, Yehuan

doi:10.1007/s11356-022-24271-3

Cited by 11 publications

(3 citation statements)

References 69 publications

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“…Many past obesity studies have observed age‐related weight gain in population cohorts 23–26 . These studies showed significant weight gain in the populations (greater than 3 kg per decade) and were found to have significant racial and sex‐based disparities 27–30 . What the present study contributes to the literature is a novel method for modeling obesity trends over time.…”

Section: Discussionmentioning

confidence: 85%

“… 23 , 24 , 25 , 26 These studies showed significant weight gain in the populations (greater than 3 kg per decade) and were found to have significant racial and sex‐based disparities. 27 , 28 , 29 , 30 What the present study contributes to the literature is a novel method for modeling obesity trends over time. Markov chains were utilized to observe the trajectories of the cohort.…”

Section: Discussionmentioning

confidence: 99%

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Stochastic modeling of obesity status in United States adults using Markov Chains: A nationally representative analysis of population health data from 2017–2020

Huang

2023

Obesity Science & Practice

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ImportanceThe prevalence of obesity among United States adults has increased from 34.9% in 2013–2014 to 42.8% in 2017–2018. Developing methods to model the increase of obesity over‐time is a necessity to know how to accurately quantify its cost and to develop solutions to combat this national public health emergency.MethodsA cross‐sectional cohort study using the publicly available National Health and Nutrition Examination Survey (NHANES 2017–2020) was conducted in individuals who completed the weight questionnaire and had accurate data for both weight at the time of survey and weight 10 years ago. To model the dynamics of obesity, a Markov transition state matrix was created, which allowed for the analysis of weight transitions over time. Bootstrap simulation was incorporated to account for uncertainty and generate multiple simulated datasets, providing a more robust estimation of the prevalence and trends in obesity within the cohort.ResultsOf the 6146 individuals who met the inclusion criteria, 3024 (49%) individuals were male and 3122 (51%) were female. There were 2252 (37%) White individuals, 1257 (20%) Hispanic individuals, 1636 (37%) Black individuals, and 739 (12%) Asian individuals. The average BMI was 30.16 (SD = 7.15), the average weight was 83.67 kilos (SD = 22.04), and the average weight change was a 3.27 kg (SD = 14.97) increase in body weight. A total of 2411 (39%) individuals lost weight, and 3735 (61%) individuals gained weight. 87 (1%) individuals were underweight (BMI <18.5), 2058 (33%) were normal weight (18.5 ≤ BMI <25), 1376 (22%) were overweight (25 ≤ BMI <30) and 2625 (43%) were in the obese category (BMI >30).ConclusionUnited States adults are at risk of transitioning from normal weight to the overweight or obese category. Markov modeling combined with bootstrap simulations can accurately model long‐term weight status.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Stochastic modeling of obesity status in United States adults using Markov Chains: A nationally representative analysis of population health data from 2017–2020

Huang

2023

Obesity Science & Practice

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“…Despite being banned decades ago, PCBs continue to be detected in the air and water (6,7). Moreover, appreciable levels of PCBs continue to be detected in the general American adult population as reported in the US National Health and Nutrition Examination Surveys (NHANES) (8). Human exposures to PCBs today occur primarily through ingestion of PCB-contaminated food and water, particularly ocean-based food sources (9,10).…”

Section: Introductionmentioning

confidence: 99%

Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model

Head

Bolatimi

Gripshover

et al. 2023

Front. Gastroenterol.

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IntroductionPolychlorinated biphenyls (PCBs) are persistent environmental toxicants that have been implicated in numerous health disorders including liver diseases such as non-alcoholic fatty liver disease (NAFLD). Toxicant-associated NAFLD, also known as toxicant-associated fatty liver disease (TAFLD), consists of a spectrum of disorders ranging from steatosis and steatohepatitis to fibrosis and hepatocellular carcinoma. Previously, our group demonstrated that 12-week exposure to the PCB mixture, Aroclor 1260, exacerbated steatohepatitis in high-fat diet (HFD)-fed mice; however, the longer-term effects of PCBs on TAFLD remain to be elucidated. This study aims to examine the longer-term effects of Aroclor 1260 (>30 weeks) in a diet-induced obesity model to better understand how duration of exposure can impact TAFLD.MethodsMale C57BL/6 mice were exposed to Aroclor 1260 (20 mg/kg) or vehicle control by oral gavage at the beginning of the study period and fed either a low-fat diet (LFD) or HFD throughout the study period.ResultsAroclor 1260 exposure (>30 weeks) led to steatohepatitis only in LFD-fed mice. Several Aroclor 1260 exposed LFD-fed mice also developed hepatocellular carcinoma (25%), which was absent in HFD-fed mice. The LFD+Aroclor1260 group also exhibited decreased hepatic Cyp7a1 expression and increased pro-fibrotic Acta2 expression. In contrast, longer term Aroclor 1260 exposure in conjunction with HFD did not exacerbate steatosis or inflammatory responses beyond those observed with HFD alone. Further, hepatic xenobiotic receptor activation by Aroclor 1260 was absent at 31 weeks post exposure, suggesting PCB redistribution to the adipose and other extra-hepatic tissues with time.DiscussionOverall, the results demonstrated that longer-term PCB exposure worsened TAFLD outcomes independent of HFD feeding and suggests altered energy metabolism as a potential mechanism fueling PCB mediated toxicity without dietary insult. Additional research exploring mechanisms for these longer-term PCB mediated toxicity in TAFLD is warranted.

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Association between combined exposure to dioxins and arthritis among US adults: a cross-sectional study

Meng,

Wang,

Yuan

et al. 2023

Environ Sci Pollut Res

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Combined exposure to multiple dioxins and dioxin-like polychlorinated biphenyls on hypertension among US adults in NHANES: a cross-sectional study under three statistical models

Cited by 11 publications

References 69 publications

Stochastic modeling of obesity status in United States adults using Markov Chains: A nationally representative analysis of population health data from 2017–2020

Stochastic modeling of obesity status in United States adults using Markov Chains: A nationally representative analysis of population health data from 2017–2020

Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model

Association between combined exposure to dioxins and arthritis among US adults: a cross-sectional study

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