Combined host-guest complex with coffee-ring effect for constructing ultrasensitive SERS substrate for phenformin hydrochloride detection in healthcare products

Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy

“…Its ability for quantification was also widely acknowledged and utilized, as shown in numerous research studies, as well as in commercial systems. 20,38 In general, good linearity was found in relatively small concentration ranges, 20,26 and logarithm linearity was prevalent with large concentration ranges. 48…”

“…[23][24][25] As one of the most promising spectroscopic analysis methods, SERS can be used for fast and nondestructive detection, and provide vibrational and rotational spectral fingerprints of chemicals under mild detection conditions, with high sensitivity and excellent selectivity. [26][27][28][29] The mechanisms of SERS was mainly thought to be the enhancement of electromagnetic field, which depended on the local surface plasmon resonance (LSPR) of metal nanostructures such as gold and silver. 30,31 Other than providing fingerprinting information for molecules, SERS was also commonly used for quantitative detection and analysis because the signal strength was usually proportional to the concentration of substances with quite good repeatability.…”

“…34 Jiang et al 35 detected illegally added sibutramine hydrochloride in healthcare products using silver nanoparticles as the enhancing substrate. Zhang et al 26 detected phenformin hydrochloride illegally added in healthcare products using Ag nanoparticles coated with β-cyclodextrin. Gao et al 36 measured palmatine illegally added in traditional Chinese medicine using size-tunable Au@Ag nanoparticles.…”

Cyclodextrin-assisted surface-enhanced Raman spectroscopy: a critical review

“…Modification of SERS substrates by CDs in most of the studies was performed during the post-synthesis step of the fabrication process by CD deposition on a clear surface of the substrate or by substitution of an original stabilizer. One-pot synthesis protocols were also proposed using the mixture of glucose (reducing agent) with native CDs (stabilizer) [36][37][38][39][40]. Finally, the use of pure native CDs for the preparation of SERS substrates by reduction of metal nanoparticles with their further stabilization by excess of CDs has been also proposed [41,42].…”

“…In all other cases, the need for investigation of the ion effect is quite questionable. CD-SERS assays were tested for the analysis of several complex objects: pharmaceutical forms [39,42,46,59,60], milk and milk powder [36], apple extract [61], soil samples [22], environmental water [37,38,45,52], artificial human urine [60], and alcoholic drinks [33,49]. The figures of merit for some of these systems are shown in Table 2.…”