Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate-Severity Disc Degeneration in Goats

Zhang, Chenghao; Gullbrand, Sarah E.; Schaer, Thomas P.; Boorman, Sophie; Elliott, Dawn M.; Chen, Weiliam; Dodge, George R.; Malhotra, Neil R.; Smith, Lachlan J.

doi:10.1089/ten.tea.2020.0103

Cited by 37 publications

(33 citation statements)

References 61 publications

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“…Human dental pulp stem cells (hDPSCs) embedded in NC-CS/GP hydrogels showed cartilage differentiation ability in vivo ( Talaat et al, 2020 ). Zhang et al prepared triple interpenetrating network hydrogels (comprising dextran, chitosan, and teleostean) loaded with mesenchymal stem cells (MSCs) for the treatment of intervertebral disk degeneration in a goat model ( Zhang C. et al, 2021 ). The results showed that the hydrogels improved the intervertebral disk height index and histology condition.…”

Section: Treatment Strategy Of Hydrogel In Advanced Osteoarthritismentioning

confidence: 99%

Hydrogels for Treatment of Different Degrees of Osteoarthritis

Wang

Qiu

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Osteoarthritis (OA) is a common disease that severely restricts human activities and degrades the quality of life. Every year, millions of people worldwide are diagnosed with osteoarthritis, placing a heavy burden on society. Hydrogels, a polymeric material with good biocompatibility and biodegradability, are a novel approach for the treatment of osteoarthritis. In recent years, this approach has been widely studied with the development of materials science and tissue engineering technology. We reviewed the research progress of hydrogels in the treatment of osteoarthritis in the past 3 years. We summarized the required hydrogel properties and current applications according to the development and treatment of osteoarthritis. Furthermore, we listed the challenges of hydrogels for different types of osteoarthritis and presented prospects for future development.

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Section: Treatment Strategy Of Hydrogel In Advanced Osteoarthritismentioning

confidence: 99%

Hydrogels for Treatment of Different Degrees of Osteoarthritis

Wang

Qiu

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…A different kind of hydrogel has been tested by Zhang et. al, consisting of a combined triple interpenetrating network made of dextran, chitosan, and teleostean [66]. In combination, the three components form a stable hydrogel that mimics the mechanical properties of NP tissue.…”

Section: Study Design Outcomes Referencesmentioning

confidence: 99%

The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc

Croft

Illien-Jünger

Grad

et al. 2021

IJMS

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Chronic low back pain (LBP) remains a challenging condition to treat, and especially to cure. If conservative treatment approaches fail, the current “gold standard” for intervertebral disc degeneration (IDD)-provoked back pain is spinal fusion. However, due to its invasive and destructive nature, the focus of orthopedic research related to the intervertebral disc (IVD) has shifted more towards cell-based therapeutic approaches. They aim to reduce or even reverse the degenerative cascade by mimicking the human body’s physiological healing system. The implementation of progenitor and/or stem cells and, in particular, the delivery of mesenchymal stromal cells (MSCs) has revealed significant potential to cure the degenerated/injured IVD. Over the past decade, many research groups have invested efforts to find ways to utilize these cells as efficiently and sustainably as possible. This narrative literature review presents a summary of achievements made with the application of MSCs for the regeneration of the IVD in recent years, including their preclinical and clinical applications. Moreover, this review presents state-of-the-art strategies on how the homing capabilities of MSCs can be utilized to repair damaged or degenerated IVDs, as well as their current limitations and future perspectives.

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“…The in vivo experimental results also show that strong mechanical properties can be maintained up to 4 weeks (Gan et al., 2017). Another triple IPN comprised of dextran, chitosan, and teleostean demonstrate the ability to restore IVD height and range of motion (Gullbrand et al., 2017), durability under 1000 cycles of compression tests (Showalter, Elliott, Chen, & Malhotra, 2015), and reduced TNF‐α expression in the NP (Zhang et al., 2020).…”

Section: Recent Advances Of Hydrogel Materials In Ivd Regenerationmentioning

confidence: 99%

Recent advances of hydrogel‐based biomaterials for intervertebral disc tissue treatment: A literature review

Zheng

2021

J Tissue Eng Regen Med

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Low back pain is an increasingly prevalent symptom mainly associated with intervertebral disc (IVD) degeneration. It is highly correlated with aging, as the nucleus pulposus (NP) dehydrates and annulus fibrosus fissure formatting, which finally results in the IVD herniation and related clinical symptoms. Hydrogels have been drawing increasing attention as the ideal candidates for IVD degeneration because of their unique properties such as biocompatibility, highly tunable mechanical properties, and especially the water absorption and retention ability resembling the normal NP tissue. Numerous innovative hydrogel polymers have been generated in the most recent years. This review article will first briefly describe the anatomy and pathophysiology of IVDs and current therapies with their limitations. Following that, the article introduces the hydrogel materials in the classification of their origins. Next, it reviews the recent hydrogel polymers explored for IVD regeneration and analyses what efforts have been made to overcome the existing limitations. Finally, the challenges and prospects of hydrogel‐based treatments for IVD tissue are also discussed. We believe that these novel hydrogel‐based strategies may shed light on new possibilities in IVD degeneration disease.

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Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate-Severity Disc Degeneration in Goats

Cited by 37 publications

References 61 publications

Hydrogels for Treatment of Different Degrees of Osteoarthritis

Hydrogels for Treatment of Different Degrees of Osteoarthritis

The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc

Recent advances of hydrogel‐based biomaterials for intervertebral disc tissue treatment: A literature review

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