Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana

Fang, Liwei; Liu, Yuqin; Zhuang, Huiyong; Liu, Wei; Wang, Xiao; Huang, Luqi

doi:10.1016/j.jchromb.2011.08.040

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…HSCCC, a liquid-liquid partition chromatography, eliminates irreversible adsorption of samples on solid support in conventional column chromatography and offers excellent recovery of target compounds [14]. Many kinds of natural products have been successfully separated and purified by HSCCC [15][16][17][18]. However, no reports have been seen on the extraction and purification of podophyllotoxin and 4 -demethylpodophyllotoxin ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Zhu

et al. 2012

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Zhu

et al. 2012

Journal of Chromatography B

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“…The major bioactive compounds in mangosteen fruits are xanthone derivatives; more than 50 xanthones have been identified from mangosteen pericarp [3]. Alpha-and γ-mangostin are the two major xanthone derivatives in mangosteen extracts, although the percentages of these substances in such extracts depend on the extraction procedure used [4][5][6]. Both mangosteen fruit extracts and the pure compounds have shown a series of in vitro biological properties, such as antioxidant [7,8], anti-inflammatory [9], antibacterial [10], cytotoxic [11,12] and cancer chemoprevention-related effects [13][14][15].…”

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confidence: 99%

Pharmacokinetic Properties of Pure Xanthones in Comparison to a Mangosteen Fruit Extract in Rats

Han

Kinghorn

et al. 2013

Planta Med

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The xanthones α-mangostin and γ-mangostin are the major bioactive compounds in Garcinia mangostana (mangosteen) fruit extracts. Previously, we reported the pharmacokinetic properties of α-mangostin in rats. The purpose of this follow-up study was to compare the pharmacokinetic characteristics of α-mangostin and γ-mangostin in rats if administered as either a pure compound or as a component of a mangosteen fruit extract. The absolute bioavailability of γ-mangostin when administered as a pure compound was determined by giving male Sprague Dawley rats 2 mg/kg γ-mangostin intravenously or 20 mg/kg orally. A 160 mg/kg aliquot of mangosteen fruit extract was administered, containing α- and γ-mangostin doses equal to 20 mg/kg and 4.5 mg/kg of each pure compound, respectively. Plasma samples were collected for both pharmacokinetic studies, and compound concentrations were measured by LC-MS/MS. The pharmacokinetic of γ-mangostin after intravenous administration followed a two-compartment body model. The half-life of the distribution phase was 2.40 min, and that of the elimination phase was 1.52 h. After oral administration, both α- and γ-mangostin underwent intensive first-pass metabolism, and both compounds were conjugated rapidly after oral administration. When given as an extract, the total absorption of α- and γ-mangostin was not increased, but the conjugation was slower, resulting in increased free (unconjugated) compound exposure when compared to pure compound administration. Since reported beneficial biological activities of mangosteen xanthones are based on the free, unconjugated compounds, food supplements containing mangosteen fruit extracts should be preferred over the administration of pure xanthones.

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“…Supercritical fluid extraction was found to be the optimal process after adjustment of pressure, temperature, time, and sample particle size . Table S5, Supporting Information, summarizes the modern extraction methods used to prepare samples of CCS during the survey period. ,,,,,,− Accelerated solvent extraction, microwave-assisted extraction, and supercritical fluid extraction were used in several cases.…”

Section: Workflowmentioning

confidence: 99%

Countercurrent Separation of Natural Products: An Update

et al. 2015

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This work assesses the current instrumentation, method development, and applications in countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC), collectively referred to as countercurrent separation (CCS). The article provides a critical review of the CCS literature from 2007 since our last review (J. Nat. Prod.2008, 71, 1489–1508), with a special emphasis on the applications of CCS in natural products research. The current state of CCS is reviewed in regard to three continuing topics (instrumentation, solvent system development, theory) and three new topics (optimization of parameters, workflow, bioactivity applications). The goals of this review are to deliver the necessary background with references for an up-to-date perspective of CCS, to point out its potential for the natural product scientist, and thereby to induce new applications in natural product chemistry, metabolome, and drug discovery research involving organisms from terrestrial and marine sources.

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Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana

Cited by 20 publications

References 26 publications

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Pharmacokinetic Properties of Pure Xanthones in Comparison to a Mangosteen Fruit Extract in Rats

Countercurrent Separation of Natural Products: An Update

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