This case report describes the treatment of a 12-years-old female with a Class III skeletal profile and dental malocclusion. The clinical examination showed concave profile, class III dental relationship, buccal crossbite on the right side, and mild crowding. The cervical vertebral maturation analysis showed the patient was on the CS3 stage. The class III malocclusion was treated with combination of banded rapid palatal expander and face mask followed by non-extraction orthodontic treatment with self-ligating system. Banded rapid palatal expander and face mask were used to improve the skeletal discrepancy. Class I maxilla-mandibular relationship was achieved along with class I molar, incisor, and canine relationship. The buccal crossbite and mild crowding were corrected, the overbite and overjet were normal, and the facial profile was improved. This case demonstrates a good result of a class III malocclusion treatment in an adolescent patient with banded rapid palatal expander/face mask and self-ligating system.