Combined spinal and general anesthesia attenuate tumor promoting effects of surgery. An experimental animal study

Inoue, Gustavo N. C.; Pimenta, Ruan; Camargo, Juliana Alves de; Viana, Nayara; Guimarães, Vanessa Valente; Srougi, Miguel; Nahas, William C.; Leite, Kátia Ramos Moreira; Reis, Sabrina T.

doi:10.1016/j.amsu.2022.103398

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…Yang et al, 2023). Anesthesia (Alstrup et al, 2023;Bleeser et al, 2023;Inoue et al, 2022) of uncontrollable or temporarily incapacitated animals represents another challenging and hazardous task. For instance, capturing wild animals in nature, handling stray animals, or returning escaped farm animals to their designated areas often necessitates the use of a needle-throwing gun for anesthesia, as depicted in Fig.…”

Section: Introductionmentioning

confidence: 99%

Proposal for a UAV-Integrated Manipulator-Based System for Capturing Animals with Anesthesia: Simulation and Experimental-Based Validation

Cabuk

2024

Preprint

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In this study, a model was proposed for performing remote anesthesia on animals using a quadrotor unmanned aerial vehicle (UAV). The proposed model integrates a manipulator into the UAV, and a mechanism system for throwing an anesthesia needle was mounted on this manipulator. A solid model of the entire proposed system was created, and a mathematical model of the system was developed. The validity of the proposed model was verified by examining the system parameters through simulation studies based on this mathematical model. Two different scenarios were constructed in the simulations. In the first scenario, the system locked on the target for a fixed position, while the second scenario was on a target that is in motion in all three dimensions. In both simulations, the UAV flew autonomously along a predetermined trajectory. The results obtained were presented graphically. In addition, the system for which a solid model was created was produced and preliminary tests were carried out in the outdoor environment. It has been shown that this proposed system can be used in a real environment.

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Section: Introductionmentioning

confidence: 99%

Proposal for a UAV-Integrated Manipulator-Based System for Capturing Animals with Anesthesia: Simulation and Experimental-Based Validation

Cabuk

2024

Preprint

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A review of enhanced recovery after surgery concept in perioperative radical prostatectomy for prostate cancer

Wu,

Jiang,

Shi

et al. 2024

J Robotic Surg

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Tumor Necrosis Factor Alpha: Implications of Anesthesia on Cancers

Tseng

Lai

Huang

et al. 2023

Cancers

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Cancer remains a major public health issue and a leading cause of death worldwide. Despite advancements in chemotherapy, radiation therapy, and immunotherapy, surgery is the mainstay of cancer treatment for solid tumors. However, tumor cells are known to disseminate into the vascular and lymphatic systems during surgical manipulation. Additionally, surgery-induced stress responses can produce an immunosuppressive environment that is favorable for cancer relapse. Up to 90% of cancer-related deaths are the result of metastatic disease after surgical resection. Emerging evidence shows that the interactions between tumor cells and the tumor microenvironment (TME) not only play decisive roles in tumor initiation, progression, and metastasis but also have profound effects on therapeutic efficacy. Tumor necrosis factor alpha (TNF-α), a pleiotropic cytokine contributing to both physiological and pathological processes, is one of the main mediators of inflammation-associated carcinogenesis in the TME. Because TNF-α signaling may modulate the course of cancer, it can be therapeutically targeted to ameliorate clinical outcomes. As the incidence of cancer continues to grow, approximately 80% of cancer patients require anesthesia during cancer care for diagnostic, therapeutic, or palliative procedures, and over 60% of cancer patients receive anesthesia for primary surgical resection. Numerous studies have demonstrated that perioperative management, including surgical manipulation, anesthetics/analgesics, and other supportive care, may alter the TME and cancer progression by affecting inflammatory or immune responses during cancer surgery, but the literature about the impact of anesthesia on the TNF-α production and cancer progression is limited. Therefore, this review summarizes the current knowledge of the implications of anesthesia on cancers from the insights of TNF-α release and provides future anesthetic strategies for improving oncological survival.

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Combined spinal and general anesthesia attenuate tumor promoting effects of surgery. An experimental animal study

Cited by 4 publications

References 46 publications

Proposal for a UAV-Integrated Manipulator-Based System for Capturing Animals with Anesthesia: Simulation and Experimental-Based Validation

Proposal for a UAV-Integrated Manipulator-Based System for Capturing Animals with Anesthesia: Simulation and Experimental-Based Validation

A review of enhanced recovery after surgery concept in perioperative radical prostatectomy for prostate cancer

Tumor Necrosis Factor Alpha: Implications of Anesthesia on Cancers

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