Combined strategy for fertility preservation in an oncologic patient: vitrification of in vitro matured oocytes and ovarian tissue freezing

González, Clara; Devesa, Marta; Boada, Montserrat; Coroleu, Buenaventura; Veiga, Anna; Barri, P. N.

doi:10.1007/s10815-011-9628-3

Cited by 19 publications

(12 citation statements)

References 21 publications

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“…The small antral follicles in the excised ovary may span diameters from less than one millimeter to around 10 millimeters. A number of studies have shown that immature oocytes can be aspirated from small antral follicles visible on the surface of the ovary after excision usually with diameters exceeding 3 millimeter [4,5]. Two pregnancies resulting from cryopreserved embryos obtained from in vitro maturation (IVM) oocytes have recently been reported from women who recovered from cancer [6,7].…”

Section: Introductionmentioning

confidence: 99%

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

Yin

Jiang

Kristensen

et al. 2016

J Assist Reprod Genet

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Purpose The aim of the study was to investigate the maturation rate of immature oocytes collected from ovarian medulla tissue normally discarded during preparation of ovarian cortical tissue for fertility preservation. Further we evaluated survival of derived MII oocytes following vitrification and warming. Methods 36 patients aged from 8 to 41 years who had one ovary excised for fertility preservation were included. Oocytes were collected from the medulla tissue and matured in vitro 44-48 h followed by vitrification. Number of oocytes collected, the rates of maturation and post-warming survival were assessed. Results On average, 11 immature oocytes were collected per patient. The overall maturation rate was 29 % irrespective of whether the ovary was transported 4-5 h on ice or obtained immediately after oophorectomy. The maturation rate in patients below 20 years of age (55 %) was significantly higher than that of patients aged 20-30 years (29 %) and above 30 years (26 %). The post-warming survival rate was 64 %. No significant relationship was observed between the number of collected oocytes and the age of patients.Conclusions Approximately three MII oocytes were obtained per patient following in vitro maturation (IVM) of immature oocytes collected from medulla tissue, of which two survived vitrification and warming. This approach represents an add-on method to potentially augment the fertility opportunity for cancer patients, especially in young women with cancer where transplantation of cortical tissue may pose a risk of relapse, but the IVM approach is currently too inefficient to be the only method used for fertility preservation.

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Section: Introductionmentioning

confidence: 99%

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

Yin

Jiang

Kristensen

et al. 2016

J Assist Reprod Genet

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“…Since the first report of this combined technique, 13 further publications [4][5][6][7][8][9][10][11][12][13][14][15][16][17] have documented this strategy, either as a case report or in a case series (summarized in Table 1). In these publications, collection of immature oocytes was attempted in patients ranging from 0 to 44 years old and COC were identified in approximately 87 % of patients, making this an interesting procedure to augment the number of oocytes available for cryopreservation.…”

Section: Introductionmentioning

confidence: 99%

“…Published in vitro maturation (IVM)-rates of COC collected ex vivo ranged from 3 % [14] to 100 % [10,15]. From the 1583 immature oocytes collected and incubated in IVM culture media reported in literature, 351 reached the metaphase II (MII) stage (22 %).…”

Section: Introductionmentioning

confidence: 99%

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

Segers¹,

Mateizel²,

Moer³

et al. 2015

J Assist Reprod Genet

129

105

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“…Vitrification of IVM oocytes has resulted in a live‐birth rate of 20%; nonetheless, survival and fertilization rates of IVM oocytes are lower than those of in vivo‐matured ones. Vitrification of in vitro matured oocytes combined with ovarian tissue cryopreservation represents a strategy for fertility preservation when ovarian stimulation is contraindicated [38].…”

Section: Strategies For Fertility Preservation In Womenmentioning

confidence: 99%

Concise Review: Fertility Preservation: An Update

González

Boada

Devesa

et al. 2012

Stem Cells Translational Medicine

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Fertility preservation is an emerging field in medicine that enables men, women, and children to maintain reproductive health when it is threatened by gonadotoxic treatment. Patients affected by other nononcologic malignancies that can impair spermatogenesis and ovogenesis can also benefit from fertility preservation treatments. Age-related infertility can also be overcome by cryopreserving gametes or embryos. The only established methods for fertility preservation in male patients are sperm cryopreservation in postpubertal age and experimental testicular tissue cryopreservation in prepubertal age. In adult women, oocyte cryopreservation is the preferred option, whereas ovarian tissue cryopreservation is the only possibility for prepubertal girls. Fertility preservation treatments must be addressed through a multidisciplinary approach that involves gynecologists, urologists, oncologists, pediatricians, and professionals in the field of medically assisted reproduction to work in coordination to provide patients with counseling and comprehensive information about fertility issues. STEM CELLS TRANSLATIONAL MEDICINE 2012;1:668 -672

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Combined strategy for fertility preservation in an oncologic patient: vitrification of in vitro matured oocytes and ovarian tissue freezing

Cited by 19 publications

References 21 publications

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe

Concise Review: Fertility Preservation: An Update

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