Combined therapy using low level laser and chitosan-policaju hydrogel for wound healing

Aragão-Neto, Adelmo C.; Soares, Paulo R.; Lima-Ribeiro, Maria Helena Madruga; Carvalho, Elaine Judite Amorim; Correia, Maria T.S.; Carneiro-da-Cunha, Maria G.

doi:10.1016/j.ijbiomac.2016.11.019

Cited by 31 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carbon photons have been shown to produce thermal and photochemical effects, with improved microcirculation, while the hydrogel dressing had a protective effect on the wound, increased skin regeneration and minimized the drying effect of carbon light therapy 92 . In another study, a hydrogel dressing combined with low‐level laser therapy showed reduction of scarring tissue, improved wound contraction and modulation of the inflammation process 93 …”

Section: Treatment Options That Promote Wound Healing When Used In Co...mentioning

confidence: 99%

“…92 In another study, a hydrogel dressing combined with low-level laser therapy showed reduction of scarring tissue, improved wound contraction and modulation of the inflammation process. 93 A recent approach for wound healing used a microcurrent device, composed of silver and zinc nanoparticles and a medical cotton cushion. The mixture of silver and zinc nanoparticles was then sprayed on one side of the cotton cushion, while the other side was covered with a thin film, in order to retain moisture and allow gas exchange.…”

Section: Tre Atment Op Ti On S That Promote Wound He Aling When Us Ed In Comb Inati On With Hydrog El S and Cre Amsmentioning

confidence: 99%

“… 92 In another study, a hydrogel dressing combined with low‐level laser therapy showed reduction of scarring tissue, improved wound contraction and modulation of the inflammation process. 93 …”

Section: Treatment Options That Promote Wound Healing When Used In Combination With Hydrogels and Creamsmentioning

confidence: 99%

See 2 more Smart Citations

Wound healing applications of creams and “smart” hydrogels

Stan

Tănase

Avram³

et al. 2021

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

Section: Treatment Options That Promote Wound Healing When Used In Co...mentioning

confidence: 99%

Section: Tre Atment Op Ti On S That Promote Wound He Aling When Us Ed In Comb Inati On With Hydrog El S and Cre Amsmentioning

confidence: 99%

See 1 more Smart Citation

Wound healing applications of creams and “smart” hydrogels

Stan

Tănase

Avram³

et al. 2021

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…liposome and protein hybrid) NP preparation was developed for efficient siRNA delivery as a gene therapy approach for wound therapy [346]. Hydrogels have also been attractive components in combination therapies; some recent examples are as follows: combination of LLLT and policaju (derived from Anacardium occidentale L gum)/chitosan hybrid hydrogels [347]; the integration of hydrogels and stem cells [337], the combination of hydrogels and platelet-rich plasma [348, 349], and so forth.…”

Section: Nanotechnology For Treatment Of Burn Infections and Woundmentioning

confidence: 99%

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Jahromi

Zangabad

Basri

et al. 2018

Advanced Drug Delivery Reviews

406

189

View full text Add to dashboard Cite

According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally employed to inhibit burn infections followed by a burn wound therapy, because systemic antibiotics have problems in reaching the infected site, coupled with increasing microbial drug resistance. Nanotechnology has provided a range of molecular designed nanostructures (NS) that can be used in both therapeutic and diagnostic applications in burns. These NSs can be divided into organic and non-organic (such as polymeric nanoparticles (NPs) and silver NPs, respectively), and many have been designed to display multifunctional activity. The present review covers the physiology of skin, burn classification, burn wound pathogenesis, animal models of burn wound infection, and various topical therapeutic approaches designed to combat infection and stimulate healing. These include biological based approaches (e.g. immune-based antimicrobial molecules, therapeutic microorganisms, antimicrobial agents, etc.), antimicrobial photo- and ultrasound-therapy, as well as nanotechnology-based wound healing approaches as a revolutionizing area. Thus, we focus on organic and non-organic NSs designed to deliver growth factors to burned skin, and scaffolds, dressings, etc. for exogenous stem cells to aid skin regeneration. Eventually, recent breakthroughs and technologies with substantial potentials in tissue regeneration and skin wound therapy (that are as the basis of burn wound therapies) are briefly taken into consideration including 3D-printing, cell-imprinted substrates, nano-architectured surfaces, and novel gene-editing tools such as CRISPR-Cas.

show abstract

“…Studies involving the use of polysaccharide as membranes, gels, and hydrogels have already been developed for important and different purposes. In the pharmaceutical field, for example, polysaccharide-based membranes have been developed as wound dressings for healing treatments due to their characteristics of biomolecule immobilization, controlled release, and adhesion [52][53][54]. In addition to have healing actions per se, these polysaccharide formulations can act as transdermal drug delivery systems, controlling the release of active ingredients [55][56][57][58][59].…”

Section: Polysaccharides and Development Of Healing Agentsmentioning

confidence: 99%

Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

et al. 2019

View full text Add to dashboard Cite

Skin injuries constitute a gateway for pathogenic bacteria that can be either part of tissue microbiota or acquired from the environmental. These microorganisms (such as Acinetobacter baumannii, Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus) produce virulence factors that impair tissue integrity and sustain the inflammatory phase leading for establishment of chronic wounds. The high levels of antimicrobial resistance have limited the therapeutic arsenal for combatting skin infections. Thus, the treatment of non-healing chronic wounds is a huge challenge for health services worldwide, imposing great socio-economic damage to the affected individuals. This scenario has encouraged the use of natural polymers, such as polysaccharide, in order to develop new formulations (membranes, nanoparticles, hydrogels, scaffolds) to be applied in the treatment of skin infections. In this non-exhaustive review, we discuss the applications of polysaccharide-based formulations in the healing of infected wounds in animal models and clinical trials. The formulations discussed in this review were prepared using alginate, cellulose, chitosan, and hyaluronic acid. In addition to have healing actions per se, these polysaccharide formulations can act as transdermal drug delivery systems, controlling the release of active ingredients (such as antimicrobial and healing agents). The papers show that these polysaccharides-based formulations are efficient in controlling infection and improve the healing, even in chronic infected wounds. These data should positively impact the design of new dressings to treat skin infections.

show abstract

Combined therapy using low level laser and chitosan-policaju hydrogel for wound healing

Cited by 31 publications

References 21 publications

Wound healing applications of creams and “smart” hydrogels

Wound healing applications of creams and “smart” hydrogels

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Polysaccharide-Based Formulations for Healing of Skin-Related Wound Infections: Lessons from Animal Models and Clinical Trials

Contact Info

Product

Resources

About