Combined use of dopamine transporter imaging (DAT-SPECT) and 123 I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy for diagnosing Parkinson's disease

Yoshii, Fumihito; Ryo, Masafuchi; Baba, Yasuhiko; Koide, Takao; Hashimoto, Jun

doi:10.1016/j.jns.2017.01.042

Cited by 34 publications

(34 citation statements)

References 40 publications

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“…The present study showed that in a cohort of 450 LBD patients, the sensitivity of both the DAT scan and MIBG myocardial scintigraphy was high for the 222 PD patients; the DAT scan was high for the 209 DLB patients; and the MIBG myocardial scintigraphy was high for the 19 autonomic‐sleep variant patients. The results are almost in accordance with those in the previous reports in which both DAT scan and MIBG myocardial scintigraphy were performed in the same cohort …”

Section: Discussionsupporting

confidence: 92%

“…Asahi et al reported 15 clinically diagnosed PD patients, of whom 13 (87%) showed abnormal results (no clear description of criteria) on both DAT and MIBG and 2 (13%) showed abnormal results on DAT alone; none (0%) showed abnormal results for MIBG alone or negative results for both. Yoshii et al reported 120 clinically diagnosed PD patients, of whom 89 (74%) showed abnormal results on both DAT (SBR < 4.5) and MIBG (HM ratio < 2.2), 21 (18%) were abnormal on DAT alone, 5 (4%) were abnormal on MIBG alone, and 5 (4%) were negative on both. Tiraboschi et al reported 30 clinically diagnosed DLB patients, 27 (90%) of whom were abnormal on both DAT (−2SD) and MIBG (HM ratio < 1.6) while none (0%) were abnormal on DAT alone, 1 (3%) was abnormal on MIBG alone, and 2 (7%) were negative on both.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, 123 I‐ioflupane (N‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl) nortropane, ie, FP‐CIT) dopamine transporter (DAT) scan detects brain dopamine depletion and 123 I‐metaiodobenzylguanidine (MIBG) myocardial scintigraphy detects peripheral norepinephrine, both with high sensitivity and specificity . However, it is not well established which neuroimaging marker is useful for identifying LBD subtypes . In order to answer this question, we analyzed clinical‐neuroimaging data of 450 LBD patients.…”

Section: Introductionmentioning

confidence: 99%

“…7 However, it is not well established which neuroimaging marker is useful for identifying LBD subtypes. [8][9][10][11][12] In order to answer this question, we analyzed clinical-neuroimaging data of 450 LBD patients.…”

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confidence: 99%

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DAT imaging and myocardial MIBG scintigraphy for Lewy body diseases: A clinical‐neuroimaging study

Sakakibara

Tateno

Aiba

et al. 2019

Neurology & Clinical Neurosc

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Objectives Neuroimaging markers for Lewy body diseases (LBDs) include dopamine transporter (DAT) scanning and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. It is unknown which marker is more useful for identifying the three major LBD subtypes: Parkinson's disease (PD), dementia with Lewy bodies (DLB), and the autonomic‐sleep variant. To answer this question, we analyzed clinical‐neuroimaging data of 450 LBD patients. Methods This study was a prospective cohort study with a recruiting period of 3.0 years, prospective follow‐up period of 2.0 ± 1.8 years, and visits at least once a year. We recruited 745 referred subjects who had undergone both DAT and MIBG tests, and the inclusion criteria accorded with published criteria of PD, DLB, and the autonomic/sleep variant (at least one of PD/DLB's known early features: orthostatic hypotension, constipation, overactive bladder, and REM sleep behavior disorder [RBD]). Results A total of 450 patients fulfilled the criteria. Among the LBD subtypes, the most common was PD (49.3%), followed by DLB (46.4%) and the autonomic/sleep variant (4.2%). DAT and MIBG tests were almost equally abnormal in PD (98.2%, 79.3%, respectively); however, between the two measures, DAT was more frequently abnormal in DLB (82.3%, 56.9%, respectively) and MIBG in the autonomic/sleep variant (57.9%, 94.7%, respectively). Still, these differences did not reach statistical significance. Conclusion Between the two neuroimaging tests, the DAT scan tended to parallel brain disease (PD/DLB), while the MIBG test tended to parallel peripheral disease (autonomic/sleep variant).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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DAT imaging and myocardial MIBG scintigraphy for Lewy body diseases: A clinical‐neuroimaging study

Sakakibara

Tateno

Aiba

et al. 2019

Neurology & Clinical Neurosc

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“…Because the frequency of her OT was similar to the resting tremor frequency seen in PD, we performed a [ 123 I]-FP-CIT DAT-SPECT study using the procedures described in our previous report [3]. For assessment of the DAT images, the SBR was calculated semi-quantitatively using DAT VIEW automated analysis software (Nihon Medi-Physics, Tokyo, Japan).…”

Section: Case Reportmentioning

confidence: 99%

Levodopa-Responsive Primary Slow Orthostatic Tremor: A Premotor Sign of Parkinson’s Disease?

Yoshii

Takahashi

Aono³

2020

Case Rep Neurol

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We present a case of primary orthostatic tremor (OT) responsive to dopaminergic medication. The patient was a 62-year-old woman, who had leg tremor on standing for 2 years. No parkinsonian or other neurological signs were observed. Surface electromyography of the quadriceps muscles showed regular 5-6 Hz muscle discharges. [ 123 I]-FP-CIT DAT-SPECT imaging revealed decreased specific binding ratio values in the striatum compared with age-matched controls. Her leg tremor almost completely disappeared following administration of levodopa 200 mg and pramipexole 0.75 mg. Since her OT with low-frequency discharge was responsive to dopaminergic medication, we speculate that it may be a premotor sign of Parkinson's disease.

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The Dopaminergic System

2019

Chemical Biology of Neurodegeneration

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Combined use of dopamine transporter imaging (DAT-SPECT) and 123 I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy for diagnosing Parkinson's disease

Cited by 34 publications

References 40 publications

DAT imaging and myocardial MIBG scintigraphy for Lewy body diseases: A clinical‐neuroimaging study

DAT imaging and myocardial MIBG scintigraphy for Lewy body diseases: A clinical‐neuroimaging study

Levodopa-Responsive Primary Slow Orthostatic Tremor: A Premotor Sign of Parkinson’s Disease?

The Dopaminergic System

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