Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis

Wang, Yi; Huang, Kun; Chen, Jie; Luo, Yanji; Jia, Yulin; Xu, Ling; Chen, Minhu; Huang, Bingsheng; Ni, Dong; Li, Zi Ping; Feng, Shi Ting

doi:10.1155/2018/6037273

Cited by 3 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Longest diameter pretherapy: The % increase in the density (%D) was assessed as: %D¼ (pretherapy density) -(posttherapy density) Â 100. 19…”

Section: Methodsmentioning

confidence: 99%

Interferons as Neoadjuvant Chemotherapy for Giant Cell Tumor: A Hospital-Based Prospective Pilot Study

Sah,

Regmi,

Niraula

et al. 2024

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

Introduction Neoadjuvant chemotherapy is now considered an effective way to treat Campanacci grade 2 and 3 giant cell tumors (GCTs). Assessment of these drugs is essential clinically, radiologically, and pathologically. This study analyzes the early results of angiogenesis inhibitors (interferons) in the aggressive GCT of bone. Methodology A prospective pilot study was conducted from January 2021 to July 2022 including eight biopsy-proven GCT patients subjected to interferon therapy. Radiological assessment was done with changes on plain radiograph, computerized tomography scan, and magnetic resonance imaging. Histopathological examination was done by changes in the biopsy and resected segment. Results Out of the eight patients included in the study, 26% (n = 3) were males and 62% (n = 5) were females, with mean age of the patients being 24.6 ± 8.48 years (range: 22–38). There was significant reduction of the size of swelling (p-value: 0.049), significant reduction in Visual Analog Scale score (p-value: 0.011), significant decrease in swelling size on radiograph (p-value: 0.012), significant marginal sclerosis (p-value: 0.001), significant neocortex formation on radiographs (p-value: 0.001), significant result in and osteoid formation (p-value: 0.001) on histology. Whereas Campanacci grade on plain radiographs, number of viable cells, and number of viable stromal cell were not statistically different in comparison with pretherapy and posttherapy status. Conclusion Interferon therapy in a GCT has potential beneficiary effect in terms of clinical, radiological, and pathological outcomes. It might prove to be an effective alternative to standard neoadjuvant chemotherapy in the management of aggressive GCT of bones. Level of Evidence III.

show abstract

“…18 Longest diameter pretherapy: The % increase in the density (%D) was assessed as: %D¼ (pretherapy density) -(posttherapy density) Â 100. 19…”

Section: Methodsmentioning

confidence: 99%

Interferons as Neoadjuvant Chemotherapy for Giant Cell Tumor: A Hospital-Based Prospective Pilot Study

Sah,

Regmi,

Niraula

et al. 2024

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

show abstract

“…Incorporation of tissue attenuation or other cutoff values might be more appropriate, yet they are still based on a single measurement of the tumor. Since a heterogeneous response is a common finding in NETs (18–20), single 2D measurements might not be representative of the actual response, because they do not reflect changes in the whole tumor (21,22).…”

Section: Introductionmentioning

confidence: 99%

CT-based radiomics to distinguish progressive from stable neuroendocrine liver metastases treated with somatostatin analogues: an explorative study

et al. 2022

View full text Add to dashboard Cite

Background Accurate response evaluation in patients with neuroendocrine liver metastases (NELM) remains a challenge. Radiomics has shown promising results regarding response assessment. Purpose To differentiate progressive (PD) from stable disease (SD) with radiomics in patients with NELM undergoing somatostatin analogue (SSA) treatment. Material and Methods A total of 46 patients with histologically confirmed gastroenteropancreatic neuroendocrine tumors (GEP-NET) with ≥1 NELM and ≥2 computed tomography (CT) scans were included. Response was assessed with Response Evaluation Criteria in Solid Tumors (RECIST1.1). Hepatic target lesions were manually delineated and analyzed with radiomics. Radiomics features were extracted from each NELM on both arterial-phase (AP) and portal-venous-phase (PVP) CT. Multiple instance learning with regularized logistic regression via LASSO penalization (with threefold cross-validation) was used to classify response. Three models were computed: (i) AP model; (ii) PVP model; and (iii) AP + PVP model for a lesion-based and patient-based outcome. Next, clinical features were added to each model. Results In total, 19 (40%) patients had PD. Median follow-up was 13 months (range 1–50 months). Radiomics models could not accurately classify response (area under the curve 0.44–0.60). Adding clinical variables to the radiomics models did not significantly improve the performance of any model. Conclusion Radiomics features were not able to accurately classify response of NELM on surveillance CT scans during SSA treatment.

show abstract

Utility of PET Scans in the Diagnosis and Management of Gastrointestinal Tumors

Menon

Mandelkern

2022

Dig Dis Sci

View full text Add to dashboard Cite

Combined Volumetric and Density Analyses of Contrast-Enhanced CT Imaging to Assess Drug Therapy Response in Gastroenteropancreatic Neuroendocrine Diffuse Liver Metastasis

Cited by 3 publications

References 33 publications

Interferons as Neoadjuvant Chemotherapy for Giant Cell Tumor: A Hospital-Based Prospective Pilot Study

Interferons as Neoadjuvant Chemotherapy for Giant Cell Tumor: A Hospital-Based Prospective Pilot Study

CT-based radiomics to distinguish progressive from stable neuroendocrine liver metastases treated with somatostatin analogues: an explorative study

Utility of PET Scans in the Diagnosis and Management of Gastrointestinal Tumors

Contact Info

Product

Resources

About