Combining Adjuvant Radiotherapy With Capecitabine in Chemotherapy-resistant Breast Cancer: Feasibility, Safety, and Toxicity

Sherry, Alexander D.; Mayer, Ingrid A.; Ayala-Peacock, D.N.; Abramson, Vandana G.; Rexer, Brent N.; Chakravarthy, A. Bapsi

doi:10.1016/j.clbc.2020.02.010

Cited by 16 publications

(2 citation statements)

References 40 publications

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“…Combining adjuvant radiotherapy with capecitabine was safe in the adjuvant treatment of breast cancer, and had comparable toxicity to radiotherapy alone [12] .…”

Section: Introductionmentioning

confidence: 91%

Concurrent capecitabine with external beam radiotherapy versus radiotherapy alone in painful bone metastasis of breast cancer origin

Ahmed

Kamal

Salah

et al. 2021

Journal of Bone Oncology

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“…Combining adjuvant radiotherapy with capecitabine was safe in the adjuvant treatment of breast cancer, and had comparable toxicity to radiotherapy alone [12] .…”

Section: Introductionmentioning

confidence: 91%

Concurrent capecitabine with external beam radiotherapy versus radiotherapy alone in painful bone metastasis of breast cancer origin

Ahmed

Kamal

Salah

et al. 2021

Journal of Bone Oncology

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“…When treating breast cancer chest wall recurrences with combined gemcitabine and radiotherapy, 100% locoregional control was achieved, although normal tissue toxicity limits this combination clinically ( 209 ). Chemotherapy resistant breast cancer treated with capecitabine and radiotherapy was retrospectively analyzed to find that there were no increased toxicities associated with the combination therapy ( 210 ). Patients with advanced, non-TNBC treated with capecitabine and radiotherapy led to 73% partial or complete response ( 211 ).…”

Section: Introductionmentioning

confidence: 99%

Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer

et al. 2022

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Breast cancer is the most prevalent non-skin cancer diagnosed in females and developing novel therapeutic strategies to improve patient outcomes is crucial. The immune system plays an integral role in the body’s response to breast cancer and modulating this immune response through immunotherapy is a promising therapeutic option. Although immune checkpoint inhibitors were recently approved for the treatment of breast cancer patients, not all patients respond to immune checkpoint inhibitors as a monotherapy, highlighting the need to better understand the biology underlying patient response. Additionally, as radiotherapy is a critical component of breast cancer treatment, understanding the interplay of radiation and immune checkpoint inhibitors will be vital as recent studies suggest that combined therapies may induce synergistic effects in preclinical models of breast cancer. This review will discuss the mechanisms supporting combined approaches with radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer. Moreover, this review will analyze the current clinical trials examining combined approaches of radiotherapy, immunotherapy, chemotherapy, and targeted therapy. Finally, this review will evaluate data regarding treatment tolerance and potential biomarkers for these emerging therapies aimed at improving breast cancer outcomes.

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Concomitant Radiation and Systemic Therapy in the Adjuvant and Metastatic Setting

Ratoša

Visani²

2022

Breast Cancer Radiation Therapy

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Combining Adjuvant Radiotherapy With Capecitabine in Chemotherapy-resistant Breast Cancer: Feasibility, Safety, and Toxicity

Cited by 16 publications

References 40 publications

Concurrent capecitabine with external beam radiotherapy versus radiotherapy alone in painful bone metastasis of breast cancer origin

Concurrent capecitabine with external beam radiotherapy versus radiotherapy alone in painful bone metastasis of breast cancer origin

Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer

Concomitant Radiation and Systemic Therapy in the Adjuvant and Metastatic Setting

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