Combining amide proton transfer-weighted and arterial spin labeling imaging to differentiate solitary brain metastases from glioblastomas

Chen, Ling; Li, Tao; Li, Yao; Zhang, Jinhuan; Li, Shuanghong; Zhu, Li; Qin, Jianli; Tang, Lifang; Zeng, Zisan

doi:10.1016/j.mri.2023.05.004

Cited by 8 publications

(5 citation statements)

References 51 publications

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“…In this review, 121 studies were included with a sample size of 6224 patients with glioblastoma, of which 64 studies corresponding to 52.89% of the total were retrospective studies [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ,…”

Section: Resultsmentioning

confidence: 99%

“…The clinical implications associated with the anatomical location of glioblastoma were analyzed in different articles, with a total of 107 articles in which a relationship was not made between the region of glioblastoma and a clinical implication [ 10 , 11 , 13 , 18 , 19 , 20 , 21 , 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 70 , 71 , …”

Section: Resultsmentioning

confidence: 99%

“…In this review, 121 studies were included with a sample size of 6224 patients with glioblastoma, of which 64 studies corresponding to 52.89% of the total were retrospective studies , 27 (22.31%) prospective studies , 24 (19.83%) case reports , 3 (2.48%) cadaveric studies [125][126][127], 2 (1.65%) cross-sectional studies [128,129], and finally, only 1 (0.83%) study that presented a case report along with a literature review [130]. The samples included in the studies were distributed across all continents with the exception of Africa; the Asian continent was represented by a total of 56 studies corresponding to 46.28% of the total studies and a sample of 2801 corresponding to 45.00% of the total patients [10,12,16,17,[19][20][21]24,27,[30][31][32]35,36,[39][40][41][42][43][44]46,49,51,53,59,[65][66][67][68][69]71,73,[75][76][77]83,[86]…”

Section: Resultsmentioning

confidence: 99%

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Association between the Anatomical Location of Glioblastoma and Its Evaluation with Clinical Considerations: A Systematic Review and Meta-Analysis

Valenzuela-Fuenzalida,

Moyano-Valarezo,

Silva-Bravo

et al. 2024

JCM

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Background: Glioblastoma is a primary malignant brain tumor; it is aggressive with a high degree of malignancy and unfavorable prognosis and is the most common type of malignant brain tumor. Glioblastomas can be located in the brain, cerebellum, brainstem, and spinal cord, originating from glial cells, particularly astrocytes. Methods: The databases MEDLINE, Scopus, Web of Science, Google Scholar, and CINAHL were researched up to January 2024. Two authors independently performed the search, study selection, and data extraction. Methodological quality was evaluated with an assurance tool for anatomical studies (AQUA). The statistical mean, standard deviation, and difference of means calculated with the Student’s t-test for presence between hemispheres and presence in the frontal and temporal lobes were analyzed. Results: A total of 123 studies met the established selection criteria, with a total of 6224 patients. In relation to the mean, GBM between hemispheres had a mean of 33.36 (SD 58.00) in the right hemisphere and a mean of 34.70 (SD 65.07) in the left hemisphere, due to the difference in averages between hemispheres. There were no statistically significant differences, p = 0.35. For the comparison between the presence of GBM in the frontal lobe and the temporal lobe, there was a mean in the frontal lobe of 23.23 (SD 40.03), while in the temporal lobe, the mean was 22.05 (SD 43.50), and for the difference in means between the frontal lobe and the temporal lobe, there was no statistically significant difference for the presence of GBM, p = 0.178. Conclusions: We believe that before a treatment, it will always be correct to know where the GBM is located and how it behaves clinically, in order to generate correct conservative or surgical treatment guidelines for each patient. We believe that more detailed studies are also needed to show why GBM is associated more with some regions than others, despite the brain structure being homologous to other regions in which GMB occurs less frequently, which is why knowing its predominant presence in brain regions is very important.

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“…In this review, 121 studies were included with a sample size of 6224 patients with glioblastoma, of which 64 studies corresponding to 52.89% of the total were retrospective studies [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ,…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…In this review, 121 studies were included with a sample size of 6224 patients with glioblastoma, of which 64 studies corresponding to 52.89% of the total were retrospective studies , 27 (22.31%) prospective studies , 24 (19.83%) case reports , 3 (2.48%) cadaveric studies [125][126][127], 2 (1.65%) cross-sectional studies [128,129], and finally, only 1 (0.83%) study that presented a case report along with a literature review [130]. The samples included in the studies were distributed across all continents with the exception of Africa; the Asian continent was represented by a total of 56 studies corresponding to 46.28% of the total studies and a sample of 2801 corresponding to 45.00% of the total patients [10,12,16,17,[19][20][21]24,27,[30][31][32]35,36,[39][40][41][42][43][44]46,49,51,53,59,[65][66][67][68][69]71,73,[75][76][77]83,[86]…”

Section: Resultsmentioning

confidence: 99%

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Association between the Anatomical Location of Glioblastoma and Its Evaluation with Clinical Considerations: A Systematic Review and Meta-Analysis

Valenzuela-Fuenzalida,

Moyano-Valarezo,

Silva-Bravo

et al. 2024

JCM

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“…It has also been reported that relatively low radiation doses used to treat cutaneous hemangiomas and tinea capitis in children or newborns have been linked to relative dangers for gliomas. 18,19…”

Section: Risk Factorsmentioning

confidence: 99%

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Habeeb,

Vengateswaran,

You

et al. 2024

J. Mater. Chem. B

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“…In the United States, malignant brain and other CNS tumors are the 6th most common cause of cancer death in adults over 40 years of age [2]. Glioblastomas and brain metastases, which are the most common malignant tumors of the CNS, are associated with high recurrence and mortality rates, and their incidence has increased in recent years [3]. Surgery, radiotherapy (RT) and chemotherapy are used in combination in the standard treatment of malignant brain tumors.…”

Section: Introductionmentioning

confidence: 99%

Comparison of ASL and DSC perfusion methods in the evaluation of response to treatment in patients with a history of treatment for malignant brain tumor

Bayraktar,

Duygulu,

Çetinoğlu

et al. 2024

BMC Med Imaging

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Objective Perfusion MRI is of great benefit in the post-treatment evaluation of brain tumors. Interestingly, dynamic susceptibility contrast-enhanced (DSC) perfusion has taken its place in routine examination for this purpose. The use of arterial spin labeling (ASL), a perfusion technique that does not require exogenous contrast material injection, has gained popularity in recent years. The aim of the study was to compare two different perfusion techniques, ASL and DSC, using qualitative and quantitative measurements and to investigate the diagnostic effectiveness of both. The fact that the number of patients is higher than in studies conducted with 3D pseudo-continious ASL (pCASL), the study group is heterogeneous as it consists of patients with both metastases and glial tumors, the use of 3D Turbo Gradient Spin Echo (TGSE), and the inclusion of visual (qualitative) assessment make our study unique. Methods Ninety patients, who were treated for malignant brain tumor, were enrolled in the retrospective study. DSC Cerebral Blood Volume (CBV), Cerebral Blood Flow (CBF) and ASL CBF maps of each case were obtained. In qualitative analysis, the lesions of the cases were visually classified as treatment-related changes (TRC) and relapse/residual mass (RRT). In the quantitative analysis, three regions of interest (ROI) measurements were taken from each case. The average of these measurements was compared with the ROI taken from the contralateral white matter and normalized values (n) were obtained. These normalized values were compared across events. Results Uncorrected DSC normalized CBV (nCBV), DSC normalized CBF (nCBF) and ASL nCBF values of RRT cases were higher than those of TRC cases (p < 0.001). DSC nCBV values were correlated with DSC nCBF (r: 0.94, p < 0.001) and correlated with ASL nCBF (r: 0.75, p < 0.001). Similarly, ASL nCBF was positively correlated with DSC nCBF (r: 0.79 p < 0.01). When the ROC curve parameters were evaluated, the cut-off values were determined as 1.211 for DSC nCBV (AUC: 0.95, 93% sensitivity, 82% specificity), 0.896 for DSC nCBF (AUC; 0.95, 93% sensitivity, 82% specificity), and 0.829 for ASL nCBF (AUC: 0.84, 78% sensitivity, 75% specificity). For qualitative evaluation (visual evaluation), inter-observer agreement was found to be good for ASL CBF (0.714), good for DSC CBF (0.790), and excellent for DSC CBV (0.822). Intra-observer agreement was also evaluated. For the first observer, good agreement was found in ASL CBF (0.626, 70% sensitive, 93% specific), in DSC CBF (0.713, 76% sensitive, 95% specific), and in DSC CBV (0.755, 87% sensitive - 88% specific). In the second observer, moderate agreement was found in ASL CBF (0.584, 61% sensitive, 97% specific) and DSC CBF (0.649, 65% sensitive, 100% specific), and excellent agreement in DSC CBV (0.800, 89% sensitive, 90% specific). Conclusion It was observed that uncorrected DSC nCBV, DSC nCBF and ASL nCBF values were well correlated with each other. In qualitative evaluation, inter-observer and intra-observer agreement was higher in DSC CBV than DSC CBF and ASL CBF. In addition, DSC CBV is found more sensitive, ASL CBF and DSC CBF are found more specific for both observers. From a diagnostic perspective, all three parameters DSC CBV, DSC CBF and ASL CBF can be used, but it was observed that the highest rate belonged to DSC CBV.

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Combining amide proton transfer-weighted and arterial spin labeling imaging to differentiate solitary brain metastases from glioblastomas

Cited by 8 publications

References 51 publications

Association between the Anatomical Location of Glioblastoma and Its Evaluation with Clinical Considerations: A Systematic Review and Meta-Analysis

Association between the Anatomical Location of Glioblastoma and Its Evaluation with Clinical Considerations: A Systematic Review and Meta-Analysis

Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma

Comparison of ASL and DSC perfusion methods in the evaluation of response to treatment in patients with a history of treatment for malignant brain tumor

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