Combining Bacteriophages with Other Antibacterial Agents to Combat Bacteria

Knežević, Petar; Sabo, Verica Aleksić

doi:10.1007/978-3-030-26736-0_10

Cited by 11 publications

(10 citation statements)

References 126 publications

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“…The maturation and release of progeny phage virions, which for lytic phages are products of bacteriolytic infections consideration, also not further developed here, is the potential for phages to display synergistic, additive, or antagonistic interactions (Chaudhry et al, 2017) with other phages, or instead with other substances that phages may be delivered in association with, i.e., such as antibiotics (Chanishvili et al, 2001;Weber-Dąbrowska et al, 2003;Kutter, 2008;Chanishvili et al, 2009;Cooper et al, 2018;Torres-Barceló and Hochberg, 2016;Abedon, 2019a;Knezevic and Sabo, 2019;Segall et al, 2019;Tagliaferri et al, 2019). Commercially as well as practically, it is also highly relevant that bacterial resistance to antibiotics is not known to result generally in cross-resistance to phages, e.g., (Sulakvelidze, 2005;Międzybrodzki et al, 2012).…”

Section: Virion Productionmentioning

confidence: 99%

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2021

Current Issues in Molecular Biology

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Pharmacology can be differentiated into two key aspects, pharmacodynamics and pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while pharmacokinetics describes the body's impact on a drug. Another way of understanding these terms is that pharmacodynamics is a description of both the positive and negative consequences of drugs attaining certain concentrations in the body while pharmacokinetics is concerned with our ability to reach and then sustain those concentrations. Unlike the drugs for which these concepts were developed, including antibiotics, the bacteriophages (or 'phages') that we consider here are not chemotherapeutics but instead are the viruses of bacteria. Here we review the pharmacology of these viruses, particularly as they can be employed to combat bacterial infections (phage therapy). Overall, an improved pharmacological understanding of phage therapy should allow for more informed development of phages as antibacterial 'drugs', allow for more rational post hoc debugging of phage therapy experiments, and encourage improved design of phage therapy protocols. Contrasting with antibiotics, however, phages as viruses impact individual bacterial cells as single virions rather than as swarms of molecules, and while they are killing bacteria, caister.com/cimb 81 Curr. Issues Mol. Biol. Vol. 40bacteriophages also can amplify phage numbers, in situ. Explorations of phage therapy pharmacology consequently can often be informed as well by basic principles of the ecological interactions between phages and bacteria as by study of the pharmacology of drugs. Bacteriophages in phage therapy thus can display somewhat unique as well as more traditional pharmacological aspects.

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Section: Virion Productionmentioning

confidence: 99%

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2021

Current Issues in Molecular Biology

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“…Those on prophylaxis and prolonged treatment regimes would benefit the most since P. aeruginosa isolated from early CF lungs of children have been found to be more similar to environmental strains and susceptible to antimicrobial treatments ( Burns et al, 2001 ; Jelsbak et al, 2007 ; Marvig et al, 2015 ). A combination of phage therapy may act synergistically with antimicrobials to potentiate the reduction or delay of MDR infection occurrence ( Knezevic and Aleksic Sabo, 2019 ; Petrovic Fabijan et al, 2020a ). Phage therapy in combination with suboptimal concentrations of antibiotics has shown potential in eradicating infection more efficiently, lowering the risk of adverse effects from long-term usage of antibiotics ( Kirby, 2012 ; Knezevic et al, 2013 ; Kamal and Dennis, 2015 ).…”

Section: Phages and Antimicrobials: Safety And The Partnership Potentmentioning

confidence: 99%

Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis

Tai

Chang

et al. 2021

Front. Microbiol.

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Individuals with cystic fibrosis (CF) are given antimicrobials as prophylaxis against bacterial lung infection, which contributes to the growing emergence of multidrug resistant (MDR) pathogens isolated. Pathogens such as Pseudomonas aeruginosa that are commonly isolated from individuals with CF are armed with an arsenal of protective and virulence mechanisms, complicating eradication and treatment strategies. While translation of phage therapy into standard care for CF has been explored, challenges such as the lack of an appropriate animal model demonstrating safety in vivo exist. In this review, we have discussed and provided some insights in the use of primary airway epithelial cells to represent the mucoenvironment of the CF lungs to demonstrate safety and efficacy of phage therapy. The combination of phage therapy and antimicrobials is gaining attention and has the potential to delay the onset of MDR infections. It is evident that efforts to translate phage therapy into standard clinical practice have gained traction in the past 5 years. Ultimately, collaboration, transparency in data publications and standardized policies are needed for clinical translation.

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Section: Virion Productionmentioning

confidence: 99%

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2020

Bacterial Viruses: Exploitation for Biocontrol and Therapeutics

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Pharmacology can be differentiated into two key aspects, pharmacodynamics and pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while pharmacokinetics describes the body's impact on a drug. Another way of understanding these terms is that pharmacodynamics is a description of both the positive and negative consequences of drugs attaining certain concentrations in the body while pharmacokinetics is concerned with our ability to reach and then sustain those concentrations. Unlike the drugs for which these concepts were developed, including antibiotics, the bacteriophages (or 'phages') that we consider here are not chemotherapeutics but instead are the viruses of bacteria. Here we review the pharmacology of these viruses, particularly as they can be employed to combat bacterial infections (phage therapy). Overall, an improved pharmacological understanding of phage therapy should allow for more informed development of phages as antibacterial 'drugs', allow for more rational post hoc debugging of phage therapy experiments, and encourage improved design of phage therapy protocols. Contrasting with antibiotics, however, phages as viruses impact individual bacterial cells as single virions rather than as swarms of molecules, and while they are killing bacteria, 49 bacteriophages also can amplify phage numbers, in situ. Explorations of phage therapy pharmacology consequently can often be informed as well by basic principles of the ecological interactions between phages and bacteria as by study of the pharmacology of drugs. Bacteriophages in phage therapy thus can display somewhat unique as well as more traditional pharmacological aspects. Abd El-Aziz, A.M., Elgaml, A., and Ali, Y.M. (2019). Bacteriophage therapy increases complement-mediated lysis of bacteria and enhances bacterial clearance after acute lung infection with multidrug-resistant Pseudomonas aeruginosa.

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Combining Bacteriophages with Other Antibacterial Agents to Combat Bacteria

Cited by 11 publications

References 126 publications

Phage Therapy: The Pharmacology of Antibacterial Viruses

Phage Therapy: The Pharmacology of Antibacterial Viruses

Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis

Phage Therapy: The Pharmacology of Antibacterial Viruses

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