Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity

Sun, Li-Han; Yu, Lung; Chan, Ya-Hsuan; Chin, Min-Han; Lee, Chi-Pin; Liao, Yi-Han

doi:10.1016/j.ejphar.2024.176559

European Journal of Pharmacology

2024

DOI: 10.1016/j.ejphar.2024.176559

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Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity

Li-Han Sun,

Lung Yu,

Ya-Hsuan Chan

et al.

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GABA system in the prefrontal cortex involved in psychostimulant addiction

Shi,

Li,

Zhang

et al. 2024

Cerebral Cortex

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Drug addiction is a chronic and relapse brain disorder. Psychostimulants such as cocaine and amphetamine are highly addictive drugs. Abuse drugs target various brain areas in the nervous system. Recent studies have shown that the prefrontal cortex (PFC) plays a key role in regulating addictive behaviors. The PFC is made up of excitatory glutamatergic cells and gamma-aminobutyric acid (GABAergic) interneurons. Recently, studies showed that GABA level was related with psychostimulant addiction. In this review, we will introduce the role and mechanism of GABA and γ-aminobutyric acid receptors (GABARs) of the PFC in regulating drug addiction, especially in psychostimulant addiction.

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GABA system in the prefrontal cortex involved in psychostimulant addiction

Shi,

Li,

Zhang

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

show abstract

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Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity

Cited by 1 publication

References 54 publications

GABA system in the prefrontal cortex involved in psychostimulant addiction

GABA system in the prefrontal cortex involved in psychostimulant addiction

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