Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds

Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics

“…Single interaction techniques include Biomembrane Force Probe (BFP), 1 Optical Tweezers 1 and Atomic Force Microscopy (AFM). 18 Options with higher throughput include magnetic tweezers, 19 Acoustic Force Spectroscopy (AFS) 20,21 or the laminar flow chamber (LFC). 28 LFC uses microbeads coated with a specific receptor driven along the surface of a small channel derivatized with a very diluted cognate ligand.…”