Combining fragmented QRS and TIMI score for predicting in-hospital short-term prognosis after acute myocardial infarction

Sheng, Qin-Hui; Hsu, Chih Chi; Li, Jianping; Hong, Tao; Huo, Yong

doi:10.1631/jzus.b1700413

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Therefore clinical acute symptoms such as acute myocardial infarction may happen when thrombogenesis progresses to a certain degree. The main principle of clinical treatment of acute myocardial infarction is to open the related infarct vessels as soon as possible to promote the recovery of myocardial blood flow and rescue the dying myocardium 11,12. Emergency PCI is one of the effective measures for the treatment of acute myocardial infarction 13.…”

Section: Discussionmentioning

confidence: 99%

Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention

Zhang

Liu

2019

Pak J Med Sci

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Objective: To investigate the clinical effect of aspirin combined with clopidogrel on acute myocardial infarction after percutaneous coronary intervention (PCI). Methods: One hundred thirty two patients with acute myocardial infarction who were admitted to the hospital between December 2016 and December 2017 were divided into a control group and an observation group according to random number table, 66 each group. Both groups were given emergency PCI and symptomatic treatment. The control group was given aspirin on the basis of conventional treatment before and after operation, while the observation group was given clopidogrel treatment on the basis of the treatment the same as the control group. The treatment lasted for 4 months. The clinical efficacy of the two groups was analyzed, and the cardiac function indicator, coagulation indicator and occurrence of adverse reactions were compared before and after treatment. Results: There was no thrombosis at the infarct site in coronary angiography after treatment in both groups. The efficacy in the observation group and control group were 89.4% and 81.8%, respectively; there was no significant difference between the two groups. The incidence of re-thrombosis in the two groups was 1.5% and 12.1% respectively, which was significantly lower in the observation group than in the control group (P<0.05). The cardiac function indicator of both groups improved after treatment, especially the observation group (P<0.05). There was no significant difference in prothrombin time (PT), activated partial thromboplastin time (APTT), prothrombin activity (PA) and platelet aggregation rate (PAR) in the two groups before treatment (P>0.05). There was also no significant difference in PT and PA before and after treatment (P>0.05). The APTT and PAR were significantly different after treatment (P<0.05), and the PAR of the observation group was significantly higher than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was 7.58%, which was not significantly different with that of the control group (12.12%) (P<0.05). Conclusion: Aspirin combined with clopidogrel can effectively reduce the occurrence of re-thrombosis after PCI and improve the recovery of cardiac function after acute operation, moreover the safety is high. It has important clinical application values. How to cite this:Zhang X, Qi L, Liu Y. Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.87 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention

Zhang

Liu

2019

Pak J Med Sci

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“…NT-proBNP andtype natriuretic peptide (BNP) are two of the most widely used natriuretic peptides, which are secreted in response to stretch. (14) These biomarkers can help detect natriuretic peptides in blood. (14) As NYHA functional class worsens in terms of function, the amount of natriuretic peptides significantly.…”

Section: Discussionmentioning

confidence: 99%

“…(14) These biomarkers can help detect natriuretic peptides in blood. (14) As NYHA functional class worsens in terms of function, the amount of natriuretic peptides significantly. Meanwhile, the result showed that the amount of natriuretic peptide was higher in HFrEF than HFpEF.…”

Section: Discussionmentioning

confidence: 99%

An Investigation into the Relationship between N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) and Fragmented QRS in Patients with Chronic Heart Failure

Ramezani¹,

Sharifi²,

Ghiasi³

et al. 2019

jemds

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BACKGROUNDHeart failure is a clinical syndrome characterized by a constellation of symptoms and signs often caused by a structural and/or functional cardiac abnormality resulting in reduced cardiac output and/or elevated intracardiac pressures. Fragmented QRS (fQRS) complex is associated with fibrosis or myocardial scar in patients with structural heart disease. Patients, especially cardiologists, are particularly concerned about heart failure in people suffering from dyspnoea. The prevalence of this disease is rising in industrial countries. The relationship between NT-proBNP and fragmented QRS in patients with chronic heart failure was investigated in this study. METHODSThe population included 42 patients suffering from chronic heart failure. fQRS was described as ≥1 additional deflection, including the peak of the R-wave or the nadir of S-wave, in at least two continuous leads. According to the absence of fQRS [fQRS (-)] or presence of fQRS (n= 22 and n= 20, respectively), the patients were assigned to two groups. The statistical package for social sciences (SPSS, version 22) was used to analyse the data. Furthermore, the normality of the data was investigated by the Shapiro-Wilk test. The chi-square test and independent t-test were used to compare the variables. RESULTS42 patients (18 women and 24 men) aged 54.78±6.43 years participated in this study. Given the fQRS at hospitalization, the patients were assigned to fQRS (-) (n= 20) and fQRS (+) (n= 22) groups. The results showed that NT-proBNP level was significantly lower in fQRS (-) group (p < 0.001), compared to fQRS (+) group. There was a significant difference between the two groups in terms of NYHA, blood pressure, hypertension, diabetes and hyperlipidaemia. The groups were compared in terms of demographic characteristics, angiography including hyperlipidaemia, and history of cardiovascular diseases. The fQRS (+) group exhibited a higher proportion of hyperlipidaemia (63.40%), troponin I (34.33 ± 21.87) and ) than the fQRS (-) group. CONCLUSIONSThe results showed a significant relationship between fQRS and the higher levels of NT-proBNP. The fQRS was associated with increased NT-proBNP and pronounced LV end-diastolic pressure in heart failure patients.

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Serum IGFBP5 as a predictor of major adverse cardiac events in patients with acute myocardial infarction

Zhu,

Cheang,

Guo

et al. 2024

International Journal of Cardiology

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Combining fragmented QRS and TIMI score for predicting in-hospital short-term prognosis after acute myocardial infarction

Cited by 6 publications

References 13 publications

Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention

Aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention

An Investigation into the Relationship between N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) and Fragmented QRS in Patients with Chronic Heart Failure

Serum IGFBP5 as a predictor of major adverse cardiac events in patients with acute myocardial infarction

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