Combining Local PWV and Quantified Arterial Changes for Calibration-Free Cuffless Blood Pressure Estimation: A Clinical Validation

Abstract

This study proposes a novel calibration-free cuffless blood pressure monitor (BPM). Unlike the cuffless BPM that requires timing correction with the traditional BPM, the calibration-free cuffless BPM can directly estimate the arterial blood pressure based on the hemodynamics mathematical model. Method: Our proposed device integrates a pair of piezoelectric ceramics as pressure sensors to sense the pressure wave in the radial artery. It calculates the local pulse wave velocity (PWV) with our waveform detection algorithm of our proposed. A photoplethysmogram (PPG) probe is set between the pair of pressure wave sensors. This PPG probe is used to monitor the radial artery's PPG intensity ratio (PIR). We design PPG signal processing algorithms to quantitative the PIR. Results: We recruited 129 participants for the blood pressure monitoring experiment. Compared with the reference sphygmomanometer, the error mean ± standard deviations (SD) systolic blood pressure (SBP) was 2.1±3.4, and correlation r-value was 0.97. diastolic blood pressure (DBP) was 0.8±4.2, and correlation r-value was 0.90, p < 0.05 is taken as statistically significant. Conclusions: A new type of wearable continuous calibration-free BPM can replace the situation that requires the use of traditional ambulatory BPM and reduce patient discomfort. Our proposed for blood pressure measurement passed all ANSI/AAMI/ISO 81060-2:20181_5.2.4.1.2 Data analysis Criterion 1 & 2 standard requirements. Index Terms-blood pressure monitor, separated by commas. photople-thysmogram, pulse wave velocity, systolic blood pressure, photoplethysmogram intensity ratio. I. INTRODUCTIONcuffless BPM is a BPM without an occluding cuff [1]. The difference between cuffless BPM and traditional BPM is that it does not need to pressurize the patient's arteries, reducing

A Hemodynamic Pulse Wave Simulator Designed for Calibration of Local Pulse Wave Velocities Measurement for Cuffless Techniques

“…In this study, we use a cuffless BPM (Accurate 24 BPM, Accurate Meditech Inc., New Taipei, Taiwan) based on local PWV measurement as the device under test (DUT) [ 34 ] with our proposed pulse wave simulator. As shown in Figure 7 , the pulse wave simulator must be started first, and the position of the elastic tube embedded in the arm phantom must be confirmed through palpation.…”