Combining Magnetic Resonance Imaging with Photothermal Therapy of CuS@BSA Nanoparticles for Cancer Theranostics

Chu, Zhongyun; Wang, Zhiming; Chen, Lina; Wang, Xiaoshuang; Huang, Chusen; Cui, Ma-Lin; Yang, Da‐Peng; Jia, Nengqin

doi:10.1021/acsanm.8b00410

Cited by 33 publications

(32 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It should be noted that the element of silicon, magnesium and iron could be attributed to their association with carbon. This result is related to (CHU et al, 2018).…”

Section: Energy Dispersive X-ray Spectrum (Edx)supporting

confidence: 51%

“…The band at 1105.25 cm-1is due to C-O stretching vibration and the band at 1035.81 cm-1 stretching from to C-N stretching of amines. The results were closed to (HUANG et al, 2010;CHU et al, 2018;ZHAO et al, 2018) when they con irm the existence of functional groups in the synthesized CuS-BSA NPs.…”

Section: Fourier Transform Infrared (Ftir) Spectroscopy Analysismentioning

confidence: 82%

“…The XRD pattern of CuS-BSA NPs observed in Figure (HUANG et al, 2010(HUANG et al, , 2017CHU et al, 2018).…”

Section: X-ray Diffraction (Xrd) Analysismentioning

confidence: 99%

See 2 more Smart Citations

Reduce the toxicity of prepared copper sulfide nanoparticles

Rashed¹,

Al-Mudallal²,

Taha³

2019

ijrps

View full text Add to dashboard Cite

Copper sulfide (CuS) nanoparticles have attracted increasing attention from biomedical ‎researchers across the globe, because of their intriguing properties, which have been ‎mainly explored for energy and catalysis related applications. The aim of the study is to ‎prepare CuS NPs by BSA entrapment to reduce the toxicity, characterizing, comparative ‎the toxicity before and after entrapment against bacteria and check the toxicity against RD ‎and L20B cell lines. CuS-BSA NPs was an easy, low toxicity and low cost chemically ‎synthesized. The CuS-BSA NPs was identified though UV-VIS ‎spectrophotometer, FTIR, XRD, SEM, EDX, and Zeta potential. The antibacterial activity ‎against different G-positive and G-negative bacterial strains have been investigated for (2 ‎mg/ml) concentrations of CuS-BSA NPs and commercial CuS. A result showed that CuS-‎BSA NPs have more antibacterial activity than commercial CuS. Using different ‎parameters of CuS-BSA NPs, its anti-cancer bioactivity for every compound synthesized in ‎RD and L20B cell line was explored, and the result proved there was significant toxicity ‎against RD and L20B cell lines.‎

show abstract

“…It should be noted that the element of silicon, magnesium and iron could be attributed to their association with carbon. This result is related to (CHU et al, 2018).…”

Section: Energy Dispersive X-ray Spectrum (Edx)supporting

confidence: 51%

Section: Fourier Transform Infrared (Ftir) Spectroscopy Analysismentioning

confidence: 82%

See 1 more Smart Citation

Reduce the toxicity of prepared copper sulfide nanoparticles

Rashed¹,

Al-Mudallal²,

Taha³

2019

ijrps

View full text Add to dashboard Cite

show abstract

“…In carbon-based material such as carbon nanotubes, the heat generated by the vibrational modes of the lattice arises from the optical transitions causing excitation and subsequent relaxation [ 144 ]. In transition metal nanoparticles like CuS, d-d transition of metal ions drives the absorption of near-infrared light [ 145 ]. During PTT, when the temperature rises up to 40–45 °C around the tumor site, it causes many changes in the cancer cells, such as protein denaturation, swelling of mitochondrial membrane, and breakage of cellular membrane leading to cell death.…”

Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

“…During PTT, when the temperature rises up to 40–45 °C around the tumor site, it causes many changes in the cancer cells, such as protein denaturation, swelling of mitochondrial membrane, and breakage of cellular membrane leading to cell death. But noncancerous cells were found to be immune to such changes up to 1 h of similar light treatment, making PTT a targeted and minimally invasive therapy [ 145 , 146 ]. The researchers revealed that the PTT dependent cancer cell death could occur from either apoptosis or necrosis, and the more desirable apoptotic pathway, which depresses inflammatory response, can be induced in cells by controlling the NIR light intensity and the exposure time [ 147 ].…”

Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

et al. 2020

View full text Add to dashboard Cite

Chitosan has emerged as a biodegradable, nontoxic polymer with multiple beneficial applications in the agricultural and biomedical sectors. As nanotechnology has evolved as a promising field, researchers have incorporated chitosan-based nanomaterials in a variety of products to enhance their efficacy and biocompatibility. Moreover, due to its inherent antimicrobial and chelating properties, and the availability of modifiable functional groups, chitosan nanoparticles were also directly used in a variety of applications. In this review, the use of chitosan-based nanomaterials in agricultural and biomedical fields related to the management of abiotic stress in plants, water availability for crops, controlling foodborne pathogens, and cancer photothermal therapy is discussed, with some insights into the possible mechanisms of action. Additionally, the toxicity arising from the accumulation of these nanomaterials in biological systems and future research avenues that had gained limited attention from the scientific community are discussed here. Overall, chitosan-based nanomaterials show promising characteristics for sustainable agricultural practices and effective healthcare in an eco-friendly manner.

show abstract

Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and can be modified chemically or biologically to render them biocompatible for advanced clinical applications. Depending on their intended use, microgels require different mechanical and structural properties, which can be engineered on demand by altering the biochemical composition, crosslink density of the polymer network, and the fabrication method. Here, the fundamental aspects of microgel research and development, as well as their specific applications for theranostics and therapy in the clinic, are discussed. A detailed overview of microgel fabrication techniques with regards to their intended clinical application is presented, while focusing on how microgels can be employed as local drug delivery materials, scavengers, and contrast agents. Moreover, microgels can act as scaffolds for tissue engineering and regeneration application. Finally, an overview of microgels is given, which already made it into pre‐clinical and clinical trials, while future challenges and chances are discussed. This review presents an instructive guideline for chemists, material scientists, and researchers in the biomedical field to introduce them to the fundamental physicochemical properties of microgels and guide them from fabrication methods via characterization techniques and functionalization of microgels toward specific applications in the clinic.

show abstract

Combining Magnetic Resonance Imaging with Photothermal Therapy of CuS@BSA Nanoparticles for Cancer Theranostics

Cited by 33 publications

References 55 publications

Reduce the toxicity of prepared copper sulfide nanoparticles

Reduce the toxicity of prepared copper sulfide nanoparticles

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

Translating Therapeutic Microgels into Clinical Applications

Contact Info

Product

Resources

About