Combining polymers with diamond-like carbon (DLC) for highly functionalized materials

Asakawa, R.; Nagashima, So; Nakamura, Yubuki; Hasebe, Terumitsu; Suzuki, Tetsuya; Hotta, Atsushi

doi:10.1016/j.surfcoat.2011.02.064

Cited by 40 publications

(22 citation statements)

References 57 publications

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“…Their good mechanical properties also make them an interesting candidate for the creation of polymer composites utilized as bone replacements. Similarly, the excellent mechanical properties of diamond like carbon make it popular as a coating for various implants [100,101,102,103]. …”

Section: Nanoparticle Graftingmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.

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Section: Nanoparticle Graftingmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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“…Besides, they also concluded that oxygen ion implantation has better wear resistance ability than carbon ion and the wear mechanism are abrasive wear and fatigue wear. Diamond like carbon is often used as coating material of polymer in biomedicine because of its high hardness and wear resistance ability [144]. Depositing diamond-like film on UHWMPE can reduce the wear volume of UHMWPE due to the enhanced mechanical strength while the friction coefficient increases because of the increasing of roughness after depositing [145] (Fig.7).…”

Section: Ultrahigh Molecular Weight Polyethylene (Uhmwpe) Biomaterialsmentioning

confidence: 99%

The recent progress of tribological biomaterials

Shi

Guo

Liu

2015

Biosurface and Biotribology

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Tribological phenomena abundantly exist in living beings, especially in human beings, such as teeth, eyes, bones, skins, heart valves and so on, and it is of meanings to reveal the mechanism of tribology in human body and fabricate artificial biomaterials to replace the damaged tissues to release the pain of patients. Alloys, ceramics and polymers are three uppermost materials used in engineering and some of them play a crucial role in biomedicine. In the paper, we provide an overview of the tribological behaviors of artificial biomaterials including alloys, ceramics and polymers. We aim to provide fundamental mechanistic and applications of tribological biomaterials, while emphasizing the advantages and disadvantages of various kinds of tribological biomaterials. Finally, some challenges and the potential promising breakthroughs are also succinctly highlighted in this field.

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“…The DLC/MPC polymer, therefore, could prevent the late thrombosis leading to restenosis by the MPC polymer, at the same time promoting the endothelialization attained by DLC. The DLC/MPC polymer including curcumin as a model drug could effectively control the drug‐release profiles . Considering further applications to a new DES, the DLC/MPC polymer should exhibit earlier endothelialization on the stent in order to prevent the restenosis for each case by using bFGF.…”

Section: Introductionmentioning

confidence: 99%

“…The DLC/MPC polymer including curcumin as a model drug could effectively control the drug-release profiles. 12,13,18 Considering further applications to a new DES, the DLC/MPC polymer should exhibit earlier endothelialization on the stent in order to prevent the restenosis for each case by using bFGF. Considering further applications to a new DES, the DLC/MPC polymer should exhibit earlier endothelialization on the stent in order to prevent the restenosis for each case by using bFGF.…”

Section: Introductionmentioning

confidence: 99%

In vitrobasic fibroblast growth factor (bFGF) delivery using an antithrombogenic 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymer coated with a micropatterned diamond‐like carbon (DLC) film

Bito

Hasebe

Maegawa

et al. 2017

J Biomedical Materials Res

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In this study, a newly designed drug-release platform composed of an antithrombogenic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was introduced, which was impregnated with basic fibroblast growth factor (bFGF) (bFGF/MPC polymer) to enhance the endothelial cell activation. The platform was also coated with an ultrathin micropatterned diamond-like carbon (DLC) film (DLC/bFGF/MPC polymer) to precisely control the drug release rate and the cell compatibility. The resulting DLC/bFGF/MPC polymer could effectively prolong the bFGF release rate by depositing the micropatterned DLC. The number of adherent platelets on the DLC/bFGF/MPC polymer was significantly lower (about 1/14) than that on a currently used stent made of stainless steel (SUS316L), indicating the enhanced antithrombogenicity in the DLC/bFGF/MPC polymer. The proliferation of endothelial cells on the DLC/bFGF/MPC polymer and the DLC/MPC polymer (without bFGF) were also examined. It was found that the optical density of HUVEC on the DLC/bFGF/MPC polymer determined by WST-8 assay was higher by 25%than that on the DLC/MPC polymer (without bFGF) measured after 72 h of incubation. Our results suggest that the released bFGF that contributes to the expression of other growth factors results in the early proliferation of the HUVEC on the DLC/bFGF/MPC polymer. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3384-3391, 2017.

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Combining polymers with diamond-like carbon (DLC) for highly functionalized materials

Cited by 40 publications

References 57 publications

Surface Modification of Polymer Substrates for Biomedical Applications

Surface Modification of Polymer Substrates for Biomedical Applications

The recent progress of tribological biomaterials

In vitrobasic fibroblast growth factor (bFGF) delivery using an antithrombogenic 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymer coated with a micropatterned diamond‐like carbon (DLC) film

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