Combining procalcitonin with the qSOFA and sepsis mortality prediction

Yu, Hua; Nie, Lu; Liu, Aibo; Wu, Kuihai; Hsein, Yenh-Chen; Yen, Debra W.; Lee, Meng-tse G.; Lee, Chien‐Chang

doi:10.1097/md.0000000000015981

Cited by 47 publications

(89 citation statements)

References 32 publications

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“…Yu H et al searched the levels of ProCT and the 30-day mortality rate, together with a quick sequential organ failure assessment (SOFA) score, in hospitalized patients. They found a significant correlation between those parameters unlike our findings [14]. Fritz et al assessed ProCT levels and mortality after cardiopulmonary bypass surgery [15].…”

Section: Discussioncontrasting

confidence: 86%

The Effects of Initial Procalcitonin Levels on Mortality Rates in Geriatric Patients Undergoing Surgery

Ipek

Karadeniz

Sitar

2020

Cureus

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Section: Discussioncontrasting

confidence: 86%

The Effects of Initial Procalcitonin Levels on Mortality Rates in Geriatric Patients Undergoing Surgery

Ipek

Karadeniz

Sitar

2020

Cureus

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“…Procalcitonin is an important prognostic indicator in septic patients, with regard to severity of sepsis [8] and in-hospital mortality [9]. In this study, when controlling for other variables, PCT values above 2.0 ng/dL were associated with positive blood cultures, increased in-hospital mortality, and septic shock.…”

Section: Discussionmentioning

confidence: 60%

Serum Procalcitonin Level Is Associated with Positive Blood Cultures, In-hospital Mortality, and Septic Shock in Emergency Department Sepsis Patients

Webb

Kramer

Stead

et al. 2020

Cureus

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This study examines the accuracy of initial and subsequent serum procalcitonin (PCT) levels in predicting positive blood cultures, in-hospital mortality, and development of septic shock in emergency department (ED) patients with severe sepsis. This study includes all patients who presented to our ED with an admission diagnosis of severe sepsis over a period of nine months. The median initial PCT was 0.58 ng/mL, interquartile range (IQR) 0.16-5.39. The median subsequent serum PCT was 2.1 ng/mL, with an IQR of 0.3-11.1. The PCT trend over the initial three hours increased in 67% of the study population. Blood cultures were positive in 38% of the cohort. The median maximum PCT in those with a negative blood culture was 1.06 ng/mL compared to 4.19 ng/mL in those with a positive blood culture (p=0.0116). Serum PCT levels >2.0 ng/mL display significant correlation with positive blood cultures, in-hospital mortality, and development of septic shock and as such may serve as a biomarker for more serious infections.

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“…28 One article included patients with symptoms of systemic infection in which PCT or blood cultures were taken within 24 hours of admission. 29 One article used the Sepsis-3 de nition 7 as inclusion criterion. 30…”

Section: Resultsmentioning

confidence: 99%

“…22,31 Only a minority of the articles used a prede ned cutoff of the studied biomarkers and scoring system. 17,25,27,29 There were no concerns of possible bias in ow and timing of the biomarkers and scoring systems that were investigated. Blood sampling was performed during ED visit in all studies.…”

Section: Quadas-2 Quality Assessmentmentioning

confidence: 99%

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

Tong‐Minh¹,

Welten²,

Endeman³

et al. 2020

Preprint

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Introduction Sepsis can be detected in an early stage in the emergency department (ED) by biomarkers and clinical scoring systems. A combination of multiple biomarkers or biomarker with clinical scoring system might result in a higher predictive value on mortality. The goal of this systematic review is to evaluate the available literature on combinations of biomarkers and clinical scoring systems on 1-month mortality in patients with sepsis in the ED.Methods We performed a systematic search using MEDLINE, PubMed, EMBASE and Google Scholar. Articles were included if they evaluated at least one biomarker combined with another biomarker or clinical scoring system and reported the diagnostic accuracy on 28 or 30 day mortality by area under the curve (AUC) in patients with sepsis. Results We found 18 articles in this systematic review. In these 18 articles, a total of 35 combinations of biomarkers and clinical scoring systems were studied of which 33 unique combinations. In total, seven different clinical scoring systems and 21 different biomarkers were investigated. The combination of procalcitonin (PCT), lactate, interleukin-6 (IL-6) and Simplified Acute Physiology Score-2 (SAPS-2) resulted in the highest AUC on 1-month mortality. Conclusion In this systematic review, the combination of PCT, IL-6, lactate and the SAPS-2 score had the highest AUC on 1-month mortality in patients with sepsis in the ED. The studies we found in this review were too heterogeneous to conclude that a certain combination it should be used in the ED to predict 1-month mortality in patients with sepsis.

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Combining procalcitonin with the qSOFA and sepsis mortality prediction

Abstract: Supplemental Digital Content is available in the text

Cited by 47 publications

References 32 publications

The Effects of Initial Procalcitonin Levels on Mortality Rates in Geriatric Patients Undergoing Surgery

The Effects of Initial Procalcitonin Levels on Mortality Rates in Geriatric Patients Undergoing Surgery

Serum Procalcitonin Level Is Associated with Positive Blood Cultures, In-hospital Mortality, and Septic Shock in Emergency Department Sepsis Patients

Predicting mortality in patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.

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