Combining Serum Carbohydrate-Deficient Transferrin and Hair Ethyl Glucuronide to Provide Optimal Information on Alcohol Use

Neels, Hugo; Yegles, Michel; Dom, Geert; Crunelle, Cleo L.

doi:10.1373/clinchem.2014.229377

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…We can summarize the alcohol biomarkers in three main categories: The direct ones ("the good"), the indirect ones correlated to alcohol abuse ("the ugly") and the indirect ones influenced by alcohol abuse, but unspecific ("the bad"). In the first category we can include fatty acids ethyl esters (FAEE) ethyl glucuronide (EtG), ethyl sulphate (EtS) and phosphathidylethanol (PEth) [5][6][7] that are metabolites related to alcohol consumption. EtG, EtS and PEth cannot be found without drinking [6,7] FAEE account for more than 20 substances and it is possible to find them in total abstainers in very small quantities due to normal metabolic production [5].…”

Section: Short Communicationmentioning

confidence: 99%

“…In the first category we can include fatty acids ethyl esters (FAEE) ethyl glucuronide (EtG), ethyl sulphate (EtS) and phosphathidylethanol (PEth) [5][6][7] that are metabolites related to alcohol consumption. EtG, EtS and PEth cannot be found without drinking [6,7] FAEE account for more than 20 substances and it is possible to find them in total abstainers in very small quantities due to normal metabolic production [5]. Carbohydrate-deficient transferrin (CDT) alone make the second category, that, exception made for its genetic variants and interindividual enzymatic related difference, it is used for forensic evaluation of alcohol abuse [8] and it is actually the biomarker used in general population analysis [9].…”

Section: Short Communicationmentioning

confidence: 99%

“…A similar study [13] reported that the analysis of these biomarkers, even if combined, is not good enough for the evaluation of alcohol abuse or dependence without the correlation with clinical context. As reported by Neels et al [7], the determination of CDT alone is, so far, the standard serum analysis for forensic examination, despite its chance to be interfered by genetic variants (<3%) and particular physio-pathological condition, e.g. the carbohydrate-deficient glycoprotein syndrome (CDGS) or the use of oral contraceptive [3,7].…”

Section: Short Communicationmentioning

confidence: 99%

“…As reported by Neels et al [7], the determination of CDT alone is, so far, the standard serum analysis for forensic examination, despite its chance to be interfered by genetic variants (<3%) and particular physio-pathological condition, e.g. the carbohydrate-deficient glycoprotein syndrome (CDGS) or the use of oral contraceptive [3,7]. The other aspect in which a consensus is important is the cut-off definition for positivity [3].…”

Section: Short Communicationmentioning

confidence: 99%

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The Markers for Alcohol Abuse: The Good, the Bad and the Ugly

Barbaro¹,

Locatelli²

2016

J Alcohol Drug Depend

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In the past decades' different biomarkers for alcohol abuse has been proposed, but, despite this, the research for newly ones is still actual. To overcome the lack of the "perfect" biomarker, at this time, different strategies has been proposed, but none of them has demonstrated the required sensibility and specificity for general population screening. As to date, the determination of carbohydrate deficient transferrin (CDT) alone is the standard serum analysis for forensic examination, despite its chance to be interfered by genetic variants (<3%) and by particular physio-pathological condition. It should be considered the evaluation of ethyl glucuronide on hair coupled with CDT on serum for forensic examination to be able to overcome the intrinsic limits of the laboratory tests and, the combination of the two together with an accurate anamnestic analysis, will give the ability to prevent misinterpretation due to the genetic and metabolic variability providing an accurate patients evaluation.

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Section: Short Communicationmentioning

confidence: 99%

Section: Short Communicationmentioning

confidence: 99%

Section: Short Communicationmentioning

confidence: 99%

Section: Short Communicationmentioning

confidence: 99%

See 2 more Smart Citations

The Markers for Alcohol Abuse: The Good, the Bad and the Ugly

Barbaro¹,

Locatelli²

2016

J Alcohol Drug Depend

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“…In addition, collecting hair samples is non-invasive and samples can be saved easily and for longer periods. Increasingly, validated cut-off scores are available, that allow distinguishing between chronic, excessive, moderate alcohol use and abstinence (Society of Hair Testing; www.soht.org) [51][52][53] . Specifically within the context of monitoring LT patients, the use of hEtG has proved to be a highly specific and practically implementable biomarker that is superior to traditional large majority of individuals with a heavy or hazardous, but not dependent drinking-pattern.…”

Section: Monitoringmentioning

confidence: 99%

Addiction specialist's role in liver transplantation procedures for alcoholic liver disease

Dom¹

2015

WJH

Self Cite

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Although liver transplantation (LT) is performed increasingly for patients with end-stage alcoholic liver disease (ALD), the topic remains controversial. Traditionally, the role of an addiction specialist focused on the screening and identification of patients with a high risk on relapse in heavy alcohol use. These patients were in many cases subsequently excluded from a further LT procedure. Recently, awareness is growing that not only screening of patients but also offering treatment, helping patients regain and maintain abstinence is essential, opening up a broader role for the addiction specialist (team) within the whole of the transplant procedure. Within this context, high-risk assessment is proposed to be an indication of increasing addiction treatment intensity, instead of being an exclusion criterion. In this review we present an overview regarding the state of the art on alcohol relapse assessment and treatment in patients with alcohol use disorders, both with and without ALD. Screening, treatment and monitoring is suggested as central roles for the addiction specialist (team) integrated within transplant centers.

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