Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations

Krt, Aljosa; Čemažar, Maja; Lovrič, Dimitrij; Serša, Gregor; Jamsek, Crt; Groselj, Aleš

doi:10.3389/fonc.2022.1025270

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Table 2 summarizes the clinical studies and case reports published thus far. 40 , 41 , 42 , 43 , 44 , 45 In summary, different types of vascular malformations have been treated, with favorable clinical outcomes. Most of the studies used intralesional bleomycin, either diluted or mixed with lidocaine.…”

Section: Overview Of Current Clinical Best Reportsmentioning

confidence: 99%

Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

Muir

Bertino

Groselj

et al. 2023

Radiology and Oncology

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Background Biomedical applications of electroporation are expanding out of the field of oncology into vaccination, treatment of arrhythmias and now in the treatment of vascular malformations. Bleomycin is a widely used sclerosing agent in the treatment of various vascular malformations. The application of electric pulses in addition to bleomycin enhances the effectiveness of the drug, as demonstrated by electrochemotherapy, which utilizes bleomycin in the treatment of tumors. The same principle is used in bleomycin electrosclerotherapy (BEST). The approach seems to be effective in the treatment of low-flow (venous and lymphatic) and, potentially, even high-flow (arteriovenous) malformations. Although there are only a few published reports to date, the surgical community is interested, and an increasing number of centers are applying BEST in the treatment of vascular malformations. Within the International Network for Sharing Practices on Electrochemotherapy (InspECT) consortium, a dedicated working group has been constituted to develop standard operating procedures for BEST and foster clinical trials. Conclusions By treatment standardization and successful completion of clinical trials demonstrating the effectiveness and safety of the approach, higher quality data and better clinical outcomes may be achieved.

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Section: Overview Of Current Clinical Best Reportsmentioning

confidence: 99%

Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

Muir

Bertino

Groselj

et al. 2023

Radiology and Oncology

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“…For the treatment of head and neck AVMs, a variety of techniques, have been employed over the past ten years such as endovascular embolization, sur-gical excision, laser therapy, or combination therapy. Embolization, followed by surgical resection, has been shown to have the best success rates in the treatment of AVMs [6].…”

Section: Introductionmentioning

confidence: 99%

Extensive Facial Arterio-Venous Malformations; Combined Approach, Embolization Followed by Surgical Reconstruction

Shoukr

Khalek

Sadaka

2023

The Egyptian Journal of Plastic and Reconstructive Surgery

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Background: Arteriovenous malformations (AVMs) are composed of an abnormal communication between arterial and venous channels without intervening capillary bed. In the face, they commonly present with asymmetry, bleeding, tooth mobility and headache. The most successful treatment to date is embolization followed by surgical excision.Objectives: To evaluate the safety and efficacy of embolization followed by surgical reconstruction in the treatment of extensive facial AVMs. Patients and Methods:In this study we present the outcome of treatment of 25 patients presented with extensive facial AVMs and admitted in the department of plastic and reconstructive surgery at Tanta University Hospital in the period from January 2016 to July 2021. Our treatment strategy was embolization guided by digital subtraction angiography followed by surgical excision.Results: Twelve patients had one anatomic facial subunit affected by the lesion while nine cases had two subunits affected and four patients had 3 subunits affected. The average length of the widest dimension of the lesion was 6cm. Most of our cases (19 of 25) were in Schobinger stage 2 at the initial presentation. All our patients were followed for at least 1 year and none of them showed any evidence of recurrence of the lesion during the follow-up period. All our cases had controlled disease. Conclusion:Preoperative embolization followed by surgical excision is the ideal treatment for extensive AVMs of the face.

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“…2 Among the recent techniques embolization followed by surgical resection is found to have best success rates. 3 Due to technical difficulties most often excision of the lesion is done after 24 to 48 hours of embolization.…”

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confidence: 99%

Immediate Surgical Excision Following Embolization of an Extensive Pediatric Facial High Flow AV Malformation

M.,

Thomas,

et al. 2024

Indian J Plast Surg

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Combining superselective catheterization and electrochemotherapy: A new technological approach to the treatment of high-flow head and neck vascular malformations

Cited by 6 publications

References 40 publications

Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

Extensive Facial Arterio-Venous Malformations; Combined Approach, Embolization Followed by Surgical Reconstruction

Immediate Surgical Excision Following Embolization of an Extensive Pediatric Facial High Flow AV Malformation

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