Combining the serum pepsinogen level and <i><scp>H</scp>elicobacter pylori</i> antibody test for predicting the histology of gastric neoplasm

Choi, Hong Seok; Lee, Sun-Young; Kim, Jeong Hwan; Sung, In‐Kyung; Park, Hyung Seok; Shim, Chan Sup; Jin, Choon Jo

doi:10.1111/1751-2980.12144

Cited by 35 publications

(38 citation statements)

References 15 publications

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“…pylori (2) group (4.17 %; odds ratio 25.8, P50.009), but the neoplasm exhibited the least advanced histology using the IgG serology test. Importantly, in this previous study we could not confirm whether there was a difference between Western and Korean serology kits (Choi et al, 2014) because the Genedia H. pylori ELISA test, which utilizes H. pylori antigen obtained from Korean strains, was not tested. In our current study, we found a high concurrence rate among the three serological tests with each displaying similar diagnostic accuracies.…”

Section: Discussionmentioning

confidence: 84%

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Validation of western Helicobacter pylori IgG antibody assays in Korean adults

Lee

Moon

Hur

et al. 2015

Journal of Medical Microbiology

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Section: Discussionmentioning

confidence: 84%

“…We recently showed that serum anti-H. pylori IgG antibodies are also useful in assessing the risk of gastric neoplasia and predicting pathology type in Korean adults (Choi et al, 2014). Of the 3328 participants included in this previous study, the incidence of gastric neoplasia was highest in the gastric atrophy (+)/H.…”

Section: Discussionmentioning

confidence: 99%

Validation of western Helicobacter pylori IgG antibody assays in Korean adults

Lee

Moon

Hur

et al. 2015

Journal of Medical Microbiology

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“…The samples were centrifuged and stored at −70 o C before analysis. Serum PG I and PG II concentrations were analyzed using the latex-enhanced turbidimetic immunoassay (HBi, Anyang, Korea) as described (8). …”

Section: Methodsmentioning

confidence: 99%

“…The serum PG assay estimates the secreting ability of the gastric mucosa cells, and therefore, it is useful when selecting asymptomatic subjects for endoscopy surveillance before and after the resection of gastric neoplasm (78910). Nonetheless, there are still controversies with regard to the link between the serum PG assay findings and abnormal upper gastrointestinal (UGI) endoscopic findings.…”

Section: Introductionmentioning

confidence: 99%

Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings

Lee

Kim

et al. 2017

J Korean Med Sci

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The serum pepsinogen (PG) assay findings are correlated with the status of Helicobacter pylori infection, but there are controversies on the link with upper gastrointestinal (UGI) endoscopic findings. The aim of this study was to determine the significance of a serum PG assay for correlating with endoscopic findings in H. pylori-seroprevalent adult population. Korean adults who visited for a health check-up were included consecutively. Subjects after gastrectomy or H. pylori eradication were excluded. After completing the serum PG assay and anti-H. pylori immunoglobulin G (IgG) titer on the same day of UGI endoscopy, subjects with equivocal serology test finding or gastric neoplasm were excluded. Of the 4,830 included subjects, 3,116 (64.5%) were seropositive for H. pylori. Seropositive finding was related to high serum PG I (P < 0.001) and PG II (P < 0.001) concentrations, low PG I/II ratio (P < 0.001), old age (P < 0.001), and male gender (P = 0.006). After adjusting age and gender, the serum PG I and II concentrations were positively correlated with the presence of nodular gastritis (NG) (all P = 0.003). The serum PG I was positively correlated with gastric ulcer (P = 0.003), and it was correlated with duodenal ulcer in seropositive subjects (P = 0.008). The PG I/II ratio was positively correlated with erosive esophagitis, while it was inversely related to chronic atrophic gastritis and metaplastic gastritis (all P < 0.001). Our findings suggest that the serum PG assay finding correlates well with the UGI endoscopic finding. A higher serum PG concentration in subjects with NG and peptic ulcer disease suggests that endoscopic findings reflect gastric secreting ability.

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“…A longitudinal study conducted in China, a high-risk of gastric cancer zone, has established that increased levels of PGI, PGII, anti-H. pylori IgG and a decreased PGI/II ratio is associated with the progression of gastric precancerous lesions [14].…”

Section: Gastro Panel a Reliable Non-invasive Testmentioning

confidence: 99%

Helicobacter pylori Infection, Gastric Cancer and Gastropanel

Loor

Dumitraşcu

2016

Romanian Journal of Internal Medicine

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Gastric cancer (GC) is one of the most widespread types of cancer worldwide. Helicobacter pylori infection has been clearly correlated with gastric carcinogenesis. At present and in the near future, the most important challenge is and will be the significant reduction of mortality due to GC. That goal can be achieved through the identification of higher-risk patients, such as those with atrophic gastritis, intestinal metaplasia and dysplasia. In this review we intend to discuss the importance of diagnosing H. pylori infection and chronic atrophic gastritis in preventing gastric cancer, using a new non-invasive test called GastroPanel. This test is a classification algorithm including four biochemical parameters pepsinogen I and II (PGI and PGII), gastrin-17 (G17), and anti-Helicobacter pylori antibodies (Ig G anti-Hp) measured in fasting sera, which allows to classify patients as having atrophic or non-atrophic gastritis and to find whether gastritis is associated or not with H. pylori infection. GastroPanel is not a "cancer test", but it can and should be used in the screening and diagnosis of subjects with a high cancer risk; still, a careful diagnostic made by superior digestive endoscopy is compulsory to find possible precancerous or cancerous lesions at an early and curable stage.

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Combining the serum pepsinogen level and Helicobacter pylori antibody test for predicting the histology of gastric neoplasm

Cited by 35 publications

References 15 publications

Validation of western Helicobacter pylori IgG antibody assays in Korean adults

Validation of western Helicobacter pylori IgG antibody assays in Korean adults

Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings

Helicobacter pylori Infection, Gastric Cancer and Gastropanel

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