Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

Miladi, Imen; Aloy, Marie-Thérèse; Armandy, Emma; Mowat, Pierre; Kryza, David; Magné, Nicolas; Tillement, Olivier; Lux, François; Billotey, Claire; Janier, Marc; Rodriguez-Lafrasse, Claire

doi:10.1016/j.nano.2014.06.013

Cited by 70 publications

(87 citation statements)

References 47 publications

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“…At 12h, it reaches 2.2, confirming a timedependency (McQuade et al, 2015). For AGuIX ® , initial enhancement in foci number seems to depend on the cell line: at 30 min, no difference between exposed and control cells was noted with B16F10 (Kotb et al, 2016) while a 1.5 fold increase was mentioned for SQ20B (Miladi et al, 2015). Nevertheless, the trend is the same with time, as 1.4 and 2.75 fold increases are reported at 24h for the two cell lines aforementioned.…”

Section: What About Dna Damage?mentioning

confidence: 75%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

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Section: What About Dna Damage?mentioning

confidence: 75%

Actual questions raised by nanoparticle radiosensitization

Brun

Sicard-Roselli

2016

Radiation Physics and Chemistry

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“…Gd 2 O 3 nanoparticles find applications in bioimaging (when tagged with fluorescent dyes) (Dosev et al 2006), in magnetic resonance imaging as contrast agent (Fortin et al 2007; Khan et al 2014) and in drug delivery (Khan et al 2014). They are also used as neutron convertors in imaging plate neutron detector (Bhattacharyya and Agrawal 1995;Gunduz and Uslu 1996;Khan et al 2014), as additives in UO 2 fuel rods (Gunduz and Uslu 1996;Khan et al 2014), in ZrO 2 to enhance its toughness (Bhattacharyya and Agrawal 1995;Chen 1996;Khan et al 2014), as a radiosensitizer (Duc et al 2011;Miladi et al 2015;Mowat et al 2011;Rancoule et al 2016;Rima et al 2013), as a catalyst (Hussein 1994;Perevalov et al 2014) and dopants for laser (Perevalov et al 2014) and colourants (Perevalov et al 2014) for special glasses.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and X-ray attenuation property of Gd2O3-based nanocomposites

2017

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In an attempt to develop an alternate to leadbased X-ray shielding material, we describe the X-ray attenuation property of nanocomposites containing Gd 2 O 3 as nanofiller and silicone resin as matrix, prepared by a simple solution-casting technique. Gd 2 O 3 nanoparticles of size 30 and 56 nm are used at concentrations of 25 and 2.5 wt%. The nanoparticles and the nanocomposites are characterized using X-ray diffraction (XRD) studies, small angle X-ray spectroscopy (SAXS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and atomic force microscopy (AFM). The X-ray attenuation property of nanocomposites, studied using an industrial X-ray unit, shows that nanocomposites containing nanoparticles of size 56 nm (G2) exhibit better attenuation than nanocomposites containing nanoparticles of size 30 nm (G1), which is attributed to the greater interfacial interaction between the G2 nanofillers and silicone matrix. In the case of nanocomposites containing G1 nanoparticles, the interfacial interaction between the nanofiller and the matrix is so weak that it results in pulling out of nanofillers, causing voids in the matrix, which act as X-ray transparent region, thereby reducing the overall X-ray attenuation property of G1 nanocomposites. This is further corroborated from the AFM images of the nanocomposites. The weight loss and heat flow curves of pure silicone matrix and the nanocomposites containing Gd 2 O 3 nanoparticles of size 30 and 56 nm show the degradation of silicone resin, due to chain scission, between 403 and 622°C. The same onset temperature (403°C) of degradation of matrix with and without nanoparticles shows that the addition of nanofillers to the matrix does not deteriorate the thermal stability of the matrix. This confirms the thermal stability of nanocomposites. Therefore, our study shows that nanocomposites containing G2 nanoparticles are potential candidates for the development of X-ray opaque fabric material.

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“…This is shown in Grall et al (15). Similarly, a greater efficiency of cell killing was also correlated with an increased induction of DNA DSB in irradiated cells preincubated with some kinds of metal nanoparticles (i.e., nanoparticles composed of high-Z atoms) (20)(21)(22).…”

mentioning

confidence: 60%

Nanodiamonds and nanoparticles as tumor cell radiosensitizers—promising results but an obscure mechanism of action

Falk

2017

Ann. Transl. Med.

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Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma

Cited by 70 publications

References 47 publications

Actual questions raised by nanoparticle radiosensitization

Actual questions raised by nanoparticle radiosensitization

Preparation, characterization and X-ray attenuation property of Gd2O3-based nanocomposites

Nanodiamonds and nanoparticles as tumor cell radiosensitizers—promising results but an obscure mechanism of action

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